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BioGRID | Network Layout for APC5 for Saccharomyces cerevisiae
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APC5

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: RMC1, YOR249C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Apc5p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with APC5

APC5 was identified with 56 protein interactions and 24 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 CDC16
  • YKL022C
    		•  The BioGRID Database Seperator Cdc16p|Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Passmore LA (2003)
    bait Grossberger R (1999)
    bait/hit Schwickart M (2004)
    bait/hit Zachariae W (1998)
    bait/hit Gavin AC (2006)
    bait Passmore LA (2005)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait Camasses A (2003)
    bait Carroll CW (2002)
    bait Carroll CW (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC4
  • YDR118W
    		•  The BioGRID Database Seperator Apc4p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Schwickart M (2004)
    bait/hit Yoon HJ (2002)
    hit Zachariae W (1998)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    Two-hybrid
    bait/hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC2
  • RSI1
  • YLR127C
    		•  The BioGRID Database Seperator Apc2p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Schwickart M (2004)
    bait Zachariae W (1998)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWM1
  • YDR260C
    		•  The BioGRID Database Seperator Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation|Swm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Hall MC (2003)
    bait/hit Passmore LA (2003)
    bait/hit Schwickart M (2004)
    bait/hit Yoon HJ (2002)
    Affinity Capture-Western
    hit Hall MC (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC23
  • YHR166C
    		•  The BioGRID Database Seperator Cdc23p|Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zachariae W (1998)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Thornton BR (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC27
  • APC3
  • SNB1
  • YBL084C
    		•  The BioGRID Database Seperator Cdc27p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Hall MC (2003)
    hit Zachariae W (1998)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MND2
  • YIR025W
    		•  The BioGRID Database Seperator Mnd2p|Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Hall MC (2003)
    bait Passmore LA (2003)
    bait/hit Yoon HJ (2002)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC9
  • YLR102C
    		•  The BioGRID Database Seperator Apc9p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Zachariae W (1998)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    Synthetic Lethality
    hit Harkness TA (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOC1
  • APC10
  • YGL240W
    		•  The BioGRID Database Seperator Doc1p|Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Grossberger R (1999)
    hit Zachariae W (1998)
    Synthetic Lethality
    hit Harkness TA (2002)
    Phenotypic Enhancement
    hit Harkness TA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC1
  • YNL172W
    		•  The BioGRID Database Seperator Apc1p|Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zachariae W (1998)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Harkness TA (2002)
    Phenotypic Suppression
    hit Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MIG1
  • CAT4
  • SSN1
  • TDS22
  • YGL035C
    		•  The BioGRID Database Seperator Mig1p|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Harkness TA (2004)
    Phenotypic Suppression
    hit Harkness TA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RLF2
  • CAC1
  • YPR018W
    		•  The BioGRID Database Seperator Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin|Rlf2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Harkness TA (2005)
    Synthetic Growth Defect
    hit Harkness TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Arnason TG (2005)
    Dosage Growth Defect
    hit Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSI1
  • CAC3
  • YBR195C
    		•  The BioGRID Database Seperator Msi1p|Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Harkness TA (2005)
    Synthetic Growth Defect
    hit Harkness TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GZF3
  • DEH1
  • NIL2
  • YJL110C
    		•  The BioGRID Database Seperator GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p|Gzf3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN2
  • YPL256C
    		•  The BioGRID Database Seperator Cln2p|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APC11
  • YDL008W
    		•  The BioGRID Database Seperator Apc11p|Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zachariae W (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FMP52
  • YER004W
    		•  The BioGRID Database Seperator Fmp52p|Protein of unknown function, localized to the mitochondrial outer membrane; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEF3
  • TEF3
  • YLR249W
    		•  The BioGRID Database Seperator Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP|Yef3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLC1
  • YGL106W
    		•  The BioGRID Database Seperator Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition|Mlc1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKR064W
  • OAF3
    		•  The BioGRID Database Seperator Oaf3p|Zinc cluster protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRP7
  • YNL005C
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the large subunit|Mrp7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC34
  • DNA6
  • UBC3
  • YDR054C
    		•  The BioGRID Database Seperator Cdc34p|Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Asf1p|Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Harkness TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIR2
  • SPT1
  • YOR038C
    		•  The BioGRID Database Seperator Hir2p|Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3, and H4 genes; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Harkness TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIR1
  • YBL008W
    		•  The BioGRID Database Seperator Hir1p|Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Harkness TA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIP2
  • SPM2
  • YGL208W
    		•  The BioGRID Database Seperator One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane|Sip2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Harkness TA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDE2
  • SRA5
  • YOR360C
    		•  The BioGRID Database Seperator High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon|Pde2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Harkness TA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC26
  • HIT3
  • SCD26
  • YFR036W
    		•  The BioGRID Database Seperator Cdc26p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Harkness TA (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • CCR1
  • GLC2
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis|Snf1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Harkness TA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF4
  • CAT3
  • SCI1
  • YGL115W
    		•  The BioGRID Database Seperator Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis|Snf4p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Harkness TA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN5
  • KAP142
  • STE21
  • YDR335W
    		•  The BioGRID Database Seperator Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP|Msn5p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Harkness TA (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSP5
  • MDP1
  • MUT2
  • NPI1
  • YER125W
    		•  The BioGRID Database Seperator Rsp5p|Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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