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BioGRID | Network Layout for ESA1 for Saccharomyces cerevisiae
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ESA1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: TAS1, YOR244W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 12 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with ESA1

ESA1 was identified with 113 protein interactions and 469 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 ARP4
  • ACT3
  • YJL081C
    		•  The BioGRID Database Seperator Arp4p|Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Kimura A (2003)
    bait Downs JA (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Affinity Capture-Western
    bait/hit Galarneau L (2000)
    Co-purification
    hit Nourani A (2001)
    Two-hybrid
    bait Steinboeck F (2007)
    Reconstituted Complex
    bait Steinboeck F (2007)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain|Yaf9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Kobor MS (2004)
    bait Zhang H (2004)
    hit Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Affinity Capture-Western
    hit Le Masson I (2003)
    bait Zhang H (2004)
    bait Auger A (2008)
    Synthetic Lethality
    hit Zhang H (2004)
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRA1
  • YHR099W
    		•  The BioGRID Database Seperator Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation|Tra1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Kimura A (2003)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Affinity Capture-Western
    hit Galarneau L (2000)
    hit Allard S (1999)
    hit Kobor MS (2004)
    Co-purification
    hit Eisen A (2001)
    hit Allard S (1999)
    hit Nourani A (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPL1
  • YFL024C
    		•  The BioGRID Database Seperator Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb|Epl1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    hit Kimura A (2003)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Affinity Capture-Western
    hit Galarneau L (2000)
    bait Boudreault AA (2003)
    bait Auger A (2008)
    Co-purification
    hit Nourani A (2001)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID21
  • EAF1
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex|Eaf1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2004)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    bait/hit Mitchell L (2008)
    Affinity Capture-Western
    hit Kobor MS (2004)
    bait Auger A (2008)
    bait Szerlong H (2008)
    Co-purification
    hit Nourani A (2001)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF3
  • YPR023C
    		•  The BioGRID Database Seperator Eaf3p|Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    hit Mitchell L (2008)
    Reconstituted Complex
    bait Eisen A (2001)
    Co-purification
    hit Eisen A (2001)
    hit Nourani A (2001)
    Synthetic Growth Defect
    hit Mitchell L (2008)
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG2
  • EAF4
  • NBN1
  • YHR090C
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1|Yng2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Loewith R (2000)
    bait Boudreault AA (2003)
    bait Nourani A (2003)
    Co-purification
    hit Nourani A (2001)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC4
  • EAF2
  • GOD1
  • YGR002C
    		•  The BioGRID Database Seperator Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex|Swc4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Hazbun TR (2003)
    bait/hit Kobor MS (2004)
    hit Krogan NJ (2004)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Co-purification
    hit Nourani A (2001)
    Affinity Capture-Western
    bait Auger A (2008)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Kimura A (2003)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Affinity Capture-Western
    hit Galarneau L (2000)
    Co-purification
    hit Nourani A (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF5
  • YEL018W
    		•  The BioGRID Database Seperator Eaf5p|Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex; protein coding
    Gene Ontology: [View List]
    Co-purification
    hit Nourani A (2001)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Affinity Capture-Western
    bait Auger A (2008)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    Synthetic Growth Defect
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF7
  • YNL136W
    		•  The BioGRID Database Seperator Eaf7p|Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2004)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    bait/hit Mitchell L (2008)
    Affinity Capture-Western
    hit Mitchell L (2008)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    Synthetic Growth Defect
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF6
  • YJR082C
    		•  The BioGRID Database Seperator Eaf6p|Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3; protein coding
    Gene Ontology: [View List]
    Co-purification
    hit Nourani A (2001)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    hit Mitchell L (2008)
    Synthetic Lethality
    bait/hit Lin YY (2008)
    Synthetic Growth Defect
    bait/hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAP1
  • PAR1
  • SNQ3
  • YML007W
    		•  The BioGRID Database Seperator Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium|Yap1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator Hhf1p|One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Clarke AS (1999)
    hit Utley RT (2005)
    Co-localization
    hit Suka N (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF2
  • YNL030W
    		•  The BioGRID Database Seperator Hhf2p|One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Clarke AS (1999)
    hit Utley RT (2005)
    Co-localization
    hit Suka N (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling|Bmh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Lottersberger F (2007)
    Synthetic Lethality
    hit Lottersberger F (2007)
    Synthetic Growth Defect
    hit Mitchell L (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin|Htz1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Keogh MC (2006)
    Synthetic Growth Defect
    hit Mitchell L (2008)
    Synthetic Lethality
    hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA2
  • H2A2
  • YBL003C
    		•  The BioGRID Database Seperator Hta2p|One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Clarke AS (1999)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS8
  • FUN15
  • VPT8
  • YAL002W
    		•  The BioGRID Database Seperator Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif|Vps8p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Mitchell L (2008)
    hit Lin YY (2008)
    Synthetic Lethality
    hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • YGL058W
    		•  The BioGRID Database Seperator Rad6p|Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p); protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Mitchell L (2008)
    hit Lin YY (2008)
    Synthetic Growth Defect
    hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD1
  • CPS50
  • FUN16
  • SAF49
  • YAR003W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7|Swd1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Mitchell L (2008)
    hit Lin YY (2008)
    Synthetic Lethality
    hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH2
  • SCD3
  • YDR099W
    		•  The BioGRID Database Seperator 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling|Bmh2p; protein coding
    Gene Ontology: