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BioGRID | Network Layout for RPB2 for Saccharomyces cerevisiae
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RPB2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SIT2, SOH2, RPO22, RPB150, YOR151C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RPB2

RPB2 was identified with 147 protein interactions and 24 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RPB3
  • YIL021W
    		•  The BioGRID Database Seperator RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    bait Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    Affinity Capture-Western
    bait Van Mullem V (2002) [10]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    Co-purification
    bait Sung P (1996) [11]
    Co-fractionation
    bait Rosenheck S (1998) [2]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO21
  • SUA8
  • RPB220
  • RPB1
  • YDL140C
    		•  The BioGRID Database Seperator RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    bait Nair D (2005) [2]
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Leblanc BP (2000) [8]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    bait Kettenberger H (2004) [11]
    Co-purification
    bait Otero G (1999) [5]
    bait Suh MH (2005) [9]
    Phenotypic Enhancement
    hit Lennon JC (1998) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB9
  • SHI1
  • SSU73
  • YGL070C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Tan Q (2003) [13]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    Co-purification
    bait Donaldson IM (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO26
  • RPB6
  • YPR187W
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Nouraini S (1996) [7]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    PCA
    hit Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT5
  • YML010W
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lindstrom DL (2003) [113]
    bait Gingras AC (2005) [75]
    bait Krogan NJ (2006) [7079]
    bait Collins SR (2007) [9064]
    Synthetic Rescue
    bait Hartzog GA (1998) [8]
    bait Reyes-Reyes M (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF14
  • SWP29
  • TFG3
  • ANC1
  • YPL129W
    		•  The BioGRID Database Seperator Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanders SL (2002) [483]
    bait Krogan NJ (2002) [90]
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB7
  • YDR404C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    Affinity Capture-Western
    bait Sheffer A (1999) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB5
  • YBR154C
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSU72
  • YNL222W
    		•  The BioGRID Database Seperator Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Pappas DL (2000) [3]
    bait Dichtl B (2002) [25]
    Two-hybrid
    bait Dichtl B (2002) [25]
    Synthetic Rescue
    bait Pappas DL (2000) [3]
    bait Reyes-Reyes M (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB11
  • YOL005C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET2
  • EZL1
  • YJL168C
    		•  The BioGRID Database Seperator Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Krogan NJ (2003) [54]
    bait Schaft D (2003) [11]
    Affinity Capture-MS
    bait Li B (2003) [5]
    bait Li J (2002) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASR1
  • YPR093C
    		•  The BioGRID Database Seperator Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait Daulny A (2008) [15]
    Biochemical Activity
    bait Daulny A (2008) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB10
  • YOR210W
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
    Gene Ontology: [View List]
    Co-crystal Structure
    hit Cramer P (2000) [12]
    Two-hybrid
    hit Flores A (1999) [20]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFG1
  • RAP74
  • SSU71
  • YGR186W
    		•  The BioGRID Database Seperator TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2004) [890]
    bait Krogan NJ (2002) [90]
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFG2
  • YGR005C
    		•  The BioGRID Database Seperator TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2002) [90]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Chung WH (2003) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB8
  • YOR224C
    		•  The BioGRID Database Seperator RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    bait Mosley AL (2009) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGR1
  • MED14
  • YLR071C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Han SJ (1999) [22]
    Affinity Capture-Western
    bait Kang JS (2001) [53]
    Co-purification
    bait Lee YC (1997) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT4
  • YGR063C
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2002) [90]
    bait Krogan NJ (2006) [7079]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IWR1
  • YDL115C
    		•  The BioGRID Database Seperator Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DST1
  • PPR2
  • YGL043W
    		•  The BioGRID Database Seperator General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Collins SR (2007) [9064]
    Phenotypic Enhancement
    bait Lennon JC (1998) [3]
    Synthetic Lethality
    hit Shaw RJ (2001) [3]
    Synthetic Growth Defect
    bait Domecq C (2010) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GFA1
  • YKL104C
    		•  The BioGRID Database Seperator Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAM1
  • ETH10
  • YLR180W
    		•  The BioGRID Database Seperator S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB4
  • CTF15
  • YJL140W
    		•  The BioGRID Database Seperator RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTR1
  • YER139C
    		•  The BioGRID Database Seperator Putative protein of unknown function; YER139C has been shown to be required for growth at high temperatures; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    bait Mosley AL (2009) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP42
  • YDR171W
    		•  The BioGRID Database Seperator Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT103
  • YDR289C
    		•  The BioGRID Database Seperator Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Kim M (2004) [19]
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFO1
  • YML088W
    		•  The BioGRID Database Seperator F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Baranes-Bachar K (2008) [19]
    Reconstituted Complex
    bait Baranes-Bachar K (2008) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP2
  • TOT2
  • YGR200C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Fellows J (2000) [14]
    Co-purification
    bait Fellows J (2000) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URA7
  • YBL039C
    		•  The BioGRID Database Seperator Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUA7
  • SOH4
  • YPR086W
    		•  The BioGRID Database Seperator Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Fan HY (1994) [8]
    Synthetic Lethality
    bait Chen BS (2004) [2]
    Synthetic Rescue
    bait Chen BS (2004) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HPR1
  • TRF1
  • YDR138W
    		•  The BioGRID Database Seperator Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Chang M (1999) [29]
    Synthetic Rescue
    bait Fan HY (1994) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCB2
  • YDR1
  • YDR397C
    		•  The BioGRID Database Seperator Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
    Gene Ontology: [View List]
    Dosage Rescue
    bait Peiro-Chova L (2007) [29]
    Synthetic Rescue
    bait Peiro-Chova L (2007) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB4
  • MED17
  • YER022W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Co-purification
    bait Takagi Y (2006) [28]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLU1
  • TIF31
  • YMR012W
    		•  The BioGRID Database Seperator eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDN1
  • REA1
  • YLR106C
    		•  The BioGRID Database Seperator Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p), may mediate ATP-dependent remodeling of 60S subunits and subsequent export from nucleoplasm to cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPN1
  • IWS1
  • YPR133C
    		•  The BioGRID Database Seperator Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotype
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EFT1
  • YOR133W
    		•  The BioGRID Database Seperator Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN28
  • YDL108W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
    Gene Ontology: [View List]
    Far Western
    bait Feaver WJ (1994) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA135
  • RPA2
  • RRN2
  • SRP3
  • YPR010C
    		•  The BioGRID Database Seperator RNA polymerase I subunit A135
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL3
  • MTR13
  • MTS1
  • NAB1
  • YDR432W
    		•  The BioGRID Database Seperator RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Tardiff DF (2007) [46]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP3
  • YER151C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
    Gene Ontology: [View List]
    Co-purification
    bait Kvint K (2008) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG7
  • TUR1
  • YBR243C
    		•  The BioGRID Database Seperator UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KRE27
  • YIL027C
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant shows K1 killer toxin resistance
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPA3
  • EPA1
  • YJR072C
    		•  The BioGRID Database Seperator Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FUS3
  • DAC2
  • YBL016W
    		•  The BioGRID Database Seperator Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID24
  • GID4
  • YBR105C
    		•  The BioGRID Database Seperator Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB5
  • MED18
  • YGR104C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Liu Y (2001) [56]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YTA7
  • YGR270W
    		•  The BioGRID Database Seperator Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Tackett AJ (2005) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
    Gene Ontology: [View List]
    Co-purification
    bait Mueller CL (2002) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF10
  • TAF25
  • TAF23
  • YDR167W
    		•  The BioGRID Database Seperator Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABD1
  • YBR236C
    		•  The BioGRID Database Seperator Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MON1
  • AUT12
  • YGL124C
    		•  The BioGRID Database Seperator Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSE2
  • MED9
  • YNR010W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Han SJ (2001) [30]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESS1
  • PIN1
  • PTF1
  • YJR017C
    		•  The BioGRID Database Seperator Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NRD1
  • YNL251C
    		•  The BioGRID Database Seperator RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Vasiljeva L (2006) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED6
  • YHR058C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAE1
  • YKL029C
    		•  The BioGRID Database Seperator Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN20
  • YFR009W
    		•  The BioGRID Database Seperator Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYS4
  • VMA41
  • STR4
  • NHS5
  • YGR155W
    		•  The BioGRID Database Seperator Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POR1
  • OMP2
  • YNL055C
    		•  The BioGRID Database Seperator Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DED81
  • YHR019C
    		•  The BioGRID Database Seperator Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEX2
  • QDS1
  • VMA45
  • SRB1
  • YNL238W
    		•  The BioGRID Database Seperator Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Martin C (1989) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUR6
  • NCB1
  • YER159C
    		•  The BioGRID Database Seperator Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
    Gene Ontology: [View List]
    Dosage Rescue
    bait Peiro-Chova L (2007) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT1
  • LPF4
  • BUR3
  • YPL082C
    		•  The BioGRID Database Seperator Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
    Gene Ontology: [View List]
    Dosage Rescue
    bait Peiro-Chova L (2007) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT6
  • SSN20
  • CRE2
  • YGR116W
    		•  The BioGRID Database Seperator Essential protein that interacts with histones and is involved in nucleosome disassembly and reassembly during transcription elongation
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Kaplan CD (2005) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Denis CL (2001) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTF1
  • CSL3
  • YGL244W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Costa PJ (2000) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGV1
  • BUR1
  • YPR161C
    		•  The BioGRID Database Seperator Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p, which is the largest subunit of RNA polymerase II; regulated by Cak1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Murray S (2001) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIT4
  • LGN4
  • YDL047W
    		•  The BioGRID Database Seperator Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Arndt KT (1989) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOH1
  • MED31
  • YGL127C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Fan HY (1996) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPC10
  • RPB12
  • YHR143W-A
    		•  The BioGRID Database Seperator RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
    Gene Ontology: [View List]
    Dosage Lethality
    bait Rubbi L (1999) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.