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BioGRID | Network Layout for STI1 for Saccharomyces cerevisiae
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STI1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YOR027W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with STI1

STI1 was identified with 47 protein interactions and 33 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Richter K (2003)
    bait Mayr C (2000)
    bait Prodromou C (1999)
    bait Catlett MG (2006)
    hit Millson SH (2008)
    Affinity Capture-Western
    bait Liu XD (1999)
    bait/hit Marsh JA (1998)
    hit Flom G (2006)
    bait Chang HC (1994)
    Affinity Capture-MS
    bait Zhao R (2005)
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Millson SH (2005)
    Co-purification
    hit Lotz GP (2003)
    Synthetic Growth Defect
    hit Chang HC (1997)
    bait Flom G (2006)
    bait/hit McClellan AJ (2007)
    Dosage Rescue
    bait Flom G (2006)
    Synthetic Lethality
    bait Flom G (2006)
    bait Zhao R (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Flom G (2006)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Johnson JL (2006)
    bait Collins SR (2007)
    Synthetic Lethality
    hit Chang HC (1997)
    hit Flom G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC37
  • SMO1
  • YDR168W
    		•  The BioGRID Database Seperator Cdc37p|Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Abbas-Terki T (2002)
    Reconstituted Complex
    bait Abbas-Terki T (2002)
    Dosage Rescue
    hit Lee P (2004)
    hit Lee P (2002)
    Synthetic Lethality
    bait Abbas-Terki T (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Wegele H (2003)
    Two-hybrid
    hit Wegele H (2003)
    Affinity Capture-Western
    hit Flom G (2006)
    Phenotypic Enhancement
    bait/hit Jones G (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP104
  • YLL026W
    		•  The BioGRID Database Seperator Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation|Hsp104p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Abbas-Terki T (2001)
    Reconstituted Complex
    bait Abbas-Terki T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA2
  • YG102
  • YLL024C
    		•  The BioGRID Database Seperator ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall|Ssa2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wegele H (2003)
    Affinity Capture-Western
    hit Flom G (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSL2
  • LOM3
  • RAD25
  • YIL143C
    		•  The BioGRID Database Seperator Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3|Ssl2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Synthetic Lethality
    hit Flom G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC7
  • LSD6
  • SAS1
  • YDL017W
    		•  The BioGRID Database Seperator Cdc7p|DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Synthetic Lethality
    bait Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBA1
  • YKL117W
    		•  The BioGRID Database Seperator Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity|Sba1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Fang Y (1998)
    hit Flom G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDJ1
  • HSP40
  • MAS5
  • YNL064C
    		•  The BioGRID Database Seperator Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family|Ydj1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Flom G (2005)
    hit Flom G (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPS1
  • YIL005W
    		•  The BioGRID Database Seperator ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family|Eps1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Sarin S (2004)
    Synthetic Lethality
    hit Sarin S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR7
  • YJR032W
    		•  The BioGRID Database Seperator Cpr7p|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Duina AA (1996)
    Synthetic Lethality
    hit Flom G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Liu XD (1999)
    Dosage Lethality
    hit Liu XD (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHC1
  • SWA5
  • YGL206C
    		•  The BioGRID Database Seperator Chc1p|Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STI1
  • YOR027W
    		•  The BioGRID Database Seperator Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMK1
  • YPR054W
    		•  The BioGRID Database Seperator Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p|Smk1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGT1
  • YOR057W
    		•  The BioGRID Database Seperator Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex|Sgt1p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URA2
  • YJL130C
    		•  The BioGRID Database Seperator Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP|Ura2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC2
  • YFR031C
    		•  The BioGRID Database Seperator Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer|Smc2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC27
  • YGL137W
    		•  The BioGRID Database Seperator Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP|Sec27p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP4
  • RNA4
  • YPR178W
    		•  The BioGRID Database Seperator Prp4p|Splicing factor, component of the U4/U6-U5 snRNP complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC1
  • ESR1
  • SAD3
  • YBR136W
    		•  The BioGRID Database Seperator Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination|Mec1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKU80
  • HDF2
  • YMR106C
    		•  The BioGRID Database Seperator Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair|Yku80p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBA1
  • YKL210W
    		•  The BioGRID Database Seperator Uba1p|Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR306C
  • YDR306C
    		•  The BioGRID Database Seperator F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain|Ydr306cp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA4
  • YG107
  • YER103W
    		•  The BioGRID Database Seperator Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation|Ssa4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wegele H (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKP2
  • YNL311C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism|Skp2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Ccr4p|Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA3
  • YG106
  • YBL075C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Ssa3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wegele H (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT3
  • YNT1
  • YTA2
  • YDR394W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B|Rpt3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDS1
  • YDR113C
    		•  The BioGRID Database Seperator Pds1p|Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Sarin S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESP1
  • YGR098C
    		•  The BioGRID Database Seperator Esp1p|Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Sarin S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEP3
  • CBF3
  • CSL1
  • YMR168C
    		•  The BioGRID Database Seperator Cep3p|Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Measday V (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSS4
  • YDR208W
    		•  The BioGRID Database Seperator Mss4p|Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Audhya A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UTP21
  • YLR409