The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for HRD1 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

HRD1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: DER3, YOL013C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 3 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with HRD1

HRD1 was identified with 57 protein interactions and 29 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 HRD3
  • YLR207W
    		•  The BioGRID Database Seperator Hrd3p|Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gardner RG (2000)
    bait/hit Gauss R (2006)
    Affinity Capture-MS
    hit Carvalho P (2006)
    Dosage Rescue
    hit Bordallo J (1999)
    Phenotypic Enhancement
    bait Denic V (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC48
  • YDL126C
    		•  The BioGRID Database Seperator ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome|Cdc48p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    hit Carvalho P (2006)
    Affinity Capture-Western
    hit Gauss R (2006)
    hit Schuberth C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEL1
  • UBX2
  • YML013W
    		•  The BioGRID Database Seperator Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain|Ubx2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Carvalho P (2006)
    Affinity Capture-Western
    hit Schuberth C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOS9
  • YDR057W
    		•  The BioGRID Database Seperator ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family|Yos9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Carvalho P (2006)
    bait Denic V (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DER1
  • YBR201W
    		•  The BioGRID Database Seperator Der1p|Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gauss R (2006)
    Affinity Capture-MS
    hit Carvalho P (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC61
  • YLR378C
    		•  The BioGRID Database Seperator Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER|Sec61p; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    bait Bordallo J (1998)
    Synthetic Rescue
    bait Bordallo J (1999)
    bait Bordallo J (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL4
  • HRD4
  • YBR170C
    		•  The BioGRID Database Seperator Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation|Npl4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gauss R (2006)
    Synthetic Rescue
    bait Hitchcock AL (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STI1
  • YOR027W
    		•  The BioGRID Database Seperator Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EFT1
  • YOR133W
    		•  The BioGRID Database Seperator Eft1p|Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IDP3
  • YNL009W
    		•  The BioGRID Database Seperator Idp3p|Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POB3
  • YML069W
    		•  The BioGRID Database Seperator Pob3p|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p); protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRS1
  • YLR060W
    		•  The BioGRID Database Seperator Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; sequence is evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase (Msf1p), but substrate binding is similar|Frs1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACS2
  • YLR153C
    		•  The BioGRID Database Seperator Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions|Acs2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEF3
  • TEF3
  • YLR249W
    		•  The BioGRID Database Seperator Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP|Yef3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALA1
  • CDC64
  • YOR335C
    		•  The BioGRID Database Seperator Ala1p|Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC60
  • YPL160W
    		•  The BioGRID Database Seperator Cdc60p|Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     USA1
  • YML029W
    		•  The BioGRID Database Seperator Protein involved in ER-associated protein degradation (ERAD); component of the Hrd1p complex; interacts with the U1 snRNP-specific protein, Snp1p|Usa1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Carvalho P (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APOB
  • FLDB
  • EG338
    		•  The BioGRID Database Seperator apoB-100|apoB-48|apolipoprotein B|apolipoprotein B48; apolipoprotein B (including Ag(x) antigen)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Hrizo SL (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • CIM5
  • YTA3
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ng W (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRC1
  • LBC1
  • YMR297W
    		•  The BioGRID Database Seperator Prc1p|Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Gauss R (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP104
  • YLL026W
    		•  The BioGRID Database Seperator Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation|Hsp104p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Schuberth C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPE3
  • YPR069C
    		•  The BioGRID Database Seperator Spe3p|Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Deak PM (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GDH1
  • URE1
  • YOR375C
    		•  The BioGRID Database Seperator Gdh1p|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM6
  • CVT4
  • VPL18
  • VPL22
  • YDL077C
    		•  The BioGRID Database Seperator Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p|Vam6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARO1
  • YDR127W
    		•  The BioGRID Database Seperator Aro1p|Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC6
  • ABP67
  • YDR129C
    		•  The BioGRID Database Seperator Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton|Sac6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EFT2
  • YDR385W
    		•  The BioGRID Database Seperator Eft2p|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THR4
  • YCR053W
    		•  The BioGRID Database Seperator Thr4p|Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HIS4
  • YCL030C
    		•  The BioGRID Database Seperator His4p|Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF1
  • YKR059W
    		•  The BioGRID Database Seperator Tif1p|Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMG1
  • YML075C
    		•  The BioGRID Database Seperator Hmg1p|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Gardner RG (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Bays NW (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYS3
  • CYI1
  • FUN35
  • STR1
  • YAL012W
    		•  The BioGRID Database Seperator Cys3p|Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET6
  • YER091C
    		•  The BioGRID Database Seperator Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs|Met6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMG2
  • YLR450W
    		•  The BioGRID Database Seperator Hmg2p|One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Gardner RG (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCP160
  • YJL080C
    		•  The BioGRID Database Seperator Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins|Scp160p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF2
  • YJL138C
    		•  The BioGRID Database Seperator Tif2p|Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TDH2
  • GLD2
  • YJR009C
    		•  The BioGRID Database Seperator Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall|Tdh2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling|Bmh1p; protein coding
    Gene Ontology: [View List]