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BioGRID | Network Layout for PAP1 for Saccharomyces cerevisiae
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PAP1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YKR002W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Pap1p|Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with PAP1

PAP1 was identified with 98 protein interactions and 7 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 FIP1
  • YJR093C
    		•  The BioGRID Database Seperator Fip1p|Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait/hit Zhao J (1999)
    bait Helmling S (2001)
    bait Ohnacker M (2000)
    Reconstituted Complex
    hit Helmling S (2001)
    bait Meinke G (2008)
    Two-hybrid
    bait Zhelkovsky A (1998)
    Biochemical Activity
    bait Zhelkovsky A (1998)
    Co-crystal Structure
    bait Meinke G (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTA1
  • FUN39
  • YAL043C
    		•  The BioGRID Database Seperator Pta1p|Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait/hit Krogan NJ (2004)
    bait Nedea E (2003)
    bait He X (2003)
    bait Walsh EP (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    hit Zhao J (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFS2
  • YNL317W
    		•  The BioGRID Database Seperator Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex|Pfs2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Dichtl B (2002)
    bait Vo LT (2001)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    bait Ohnacker M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSU72
  • YNL222W
    		•  The BioGRID Database Seperator Ssu72p|Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Nedea E (2003)
    bait He X (2003)
    bait Dichtl B (2002)
    hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPE1
  • YKL059C
    		•  The BioGRID Database Seperator Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif|Mpe1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Nedea E (2003)
    bait Vo LT (2001)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CFT2
  • YDH1
  • YLR115W
    		•  The BioGRID Database Seperator Cft2p|Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    hit Zhao J (1999)
    Co-purification
    bait Preker PJ (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTI1
  • YGR156W
    		•  The BioGRID Database Seperator Pta1p Interacting protein|Pti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Nedea E (2003)
    bait Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YSH1
  • BRR5
  • YLR277C
    		•  The BioGRID Database Seperator Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs|Ysh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    hit Zhao J (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CFT1
  • YHH1
  • YDR301W
    		•  The BioGRID Database Seperator Cft1p|RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait/hit Zhao J (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YTH1
  • YPR107C
    		•  The BioGRID Database Seperator Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation|Yth1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD2
  • CPS35
  • SAF37
  • YKL018W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination|Swd2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Nedea E (2003)
    bait Krogan NJ (2006)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REF2
  • YDR195W
    		•  The BioGRID Database Seperator RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes|Ref2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Nedea E (2003)
    bait Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLC7
  • CID1
  • DIS2
  • YER133W
    		•  The BioGRID Database Seperator Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p|Glc7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Walsh EP (2002)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNA14
  • YMR061W
    		•  The BioGRID Database Seperator Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex|Rna14p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Synthetic Lethality
    hit Minvielle-Sebastia L (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRP6
  • YOR001W
    		•  The BioGRID Database Seperator Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus|Rrp6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Burkard KT (2000)
    Synthetic Rescue
    hit Hilleren P (2001)
    hit Burkard KT (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit del Olmo M (1997)
    Two-hybrid
    hit del Olmo M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL8A
  • MAK7
  • YHL033C
    		•  The BioGRID Database Seperator Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits|Rpl8ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO85
  • LDB15
  • YPL031C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5|Pho85p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wu JS (1998)
    Two-hybrid
    bait/hit Wu JS (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBA2
  • UAL1
  • YDR390C
    		•  The BioGRID Database Seperator Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability|Uba2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit del Olmo M (1997)
    Two-hybrid
    hit del Olmo M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCF11
  • YDR228C
    		•  The BioGRID Database Seperator Pcf11p|mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HCA4
  • DBP4
  • ECM24
  • YJL033W
    		•  The BioGRID Database Seperator Hca4p|Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIR1
  • PIP1
  • YER032W
    		•  The BioGRID Database Seperator Fir1p|Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit del Olmo M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF2
  • TAF150
  • TSM1
  • YCR042C
    		•  The BioGRID Database Seperator TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation|Taf2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAB1
  • YER165W
    		•  The BioGRID Database Seperator Pab1p|Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Zhelkovsky A (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRP1
  • KAP60
  • SCM1
  • YNL189W
    		•  The BioGRID Database Seperator Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation|Srp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS53
  • YJL029C
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting|Vps53p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT5
  • YML010W
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing|Spt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lindstrom DL (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRF4
  • PAP2
  • YOL115W
    		•  The BioGRID Database Seperator Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase|Pap2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Houseley J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LCP5
  • YER127W
    		•  The BioGRID Database Seperator Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus|Lcp5p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Wiederkehr T (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNA15
  • YGL044C
    		•  The BioGRID Database Seperator Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p|Rna15p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Minvielle-Sebastia L (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RET1
  • PDS2
  • RPC128
  • RPC2
  • YOR207C
    		•  The BioGRID Database Seperator Ret1p|Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Briggs MW (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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