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BioGRID | Network Layout for DID4 for Saccharomyces cerevisiae
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DID4

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: CHM2, GRD7, REN1, VPL2, VPS2, VPT14, YKL002W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis|Did4p; protein coding
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PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 6 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with DID4

DID4 was identified with 17 protein interactions and 15 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 VPS4
  • CSC1
  • DID6
  • END13
  • YPR173C
    		•  The BioGRID Database Seperator AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism|Vps4p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Vajjhala PR (2007) [5]
    Far Western
    bait Obita T (2007) [3]
    Co-crystal Structure
    bait Obita T (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF7
  • DID1
  • VPS32
  • RNS4
  • YLR025W
    		•  The BioGRID Database Seperator One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes|Snf7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Babst M (2002) [6]
    PCA
    bait/hit Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS24
  • DID3
  • YKL041W
    		•  The BioGRID Database Seperator One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway|Vps24p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Babst M (2002) [8]
    bait/hit Babst M (2002) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008) [2594]
    Synthetic Lethality
    bait Lin YY (2008) [2594]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC36
  • DNA19
  • NOT2
  • YDL165W
    		•  The BioGRID Database Seperator Cdc36p|Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator Hek2p|RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length; protein coding
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait/hit Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JSN1
  • PUF1
  • YJR091C
    		•  The BioGRID Database Seperator Jsn1p|Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DID2
  • CHM1
  • FTI1
  • VPS46
  • YKR035W-A
    		•  The BioGRID Database Seperator Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors|Did2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DID4
  • CHM2
  • GRD7
  • REN1
  • YKL002W
    		•  The BioGRID Database Seperator Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis|Did4p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008) [2616]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOB2
  • YFL035C
  • YFL035C-A
  • YFL034C-B
    		•  The BioGRID Database Seperator Component of the RAM signaling network, localizes and activates the Ace2p in the daughter cell nucleus to direct daughter cell-specific transcription of several genes involved in cell separation; Mob1p-like protein|Mob2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YER121W
  • YER121W
    		•  The BioGRID Database Seperator Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy|Yer121wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG17
  • APG17
  • YLR423C
    		•  The BioGRID Database Seperator Atg17p|Scaffold potein responsible for pre-autophagosomal structure organization; interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STD1
  • MSN3
  • SFS3
  • YOR047C
    		•  The BioGRID Database Seperator Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p|Std1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC24
  • YMR117C
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering|Spc24p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID21
  • EAF1
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex|Eaf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008) [2594]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Synthetic Haploinsufficiency
    bait Haarer B (2007) [201]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait McClellan AJ (2007) [1414]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IST1
  • YNL265C
    		•  The BioGRID Database Seperator Ist1p|Putative translation initiation factor, as suggested by computational analysis of large-scale protein-protein interaction data; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Rue SM (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007) [1414]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG2
  • EAF4
  • NBN1
  • YHR090C
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1|Yng2p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008) [2594]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA4
  • DOS1
  • MUT4
  • NPI2
  • YDR069C
    		•  The BioGRID Database Seperator Doa4p|Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Amerik AY (2000) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP2
  • CAF1
  • YNR052C
    		•  The BioGRID Database Seperator Pop2p|RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Ccr4p|Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM8
  • PAL3
  • YGL046W
  • YGL045W
    		•  The BioGRID Database Seperator Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF|Rim8p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Hayashi M (2005) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM9
  • YMR063W
    		•  The BioGRID Database Seperator Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein|Rim9p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Hayashi M (2005) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM21
  • PAL2
  • YNL294C
    		•  The BioGRID Database Seperator Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH|Rim21p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Hayashi M (2005) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR198W
  • YPP1
    		•  The BioGRID Database Seperator Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene|Ypp1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Flower TR (2007) [32]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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