| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| SMT3 |
YDR510W |
|
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
|
|
|
|
|
| BNI4 |
YNL233W |
|
Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
|
|
|
|
|
| DUN1 |
YDL101C |
|
Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
|
|
|
|
|
| PHO23 |
YNL097C |
|
Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
|
|
|
|
|
| UBP3 |
YER151C |
|
Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
|
|
|
|
|
| CHS5 |
CAL3YLR330W |
|
Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
|
|
|
|
|
| ADA2 |
SWI8YDR448W |
|
Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
|
|
|
|
|
| KAR9 |
YPL269W |
|
Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
|
|
|
|
|
| SAP1 |
YER047C |
|
Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
|
|
|
|
|
| NAB2 |
YGL122C |
|
Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
|
|
|
|
|
| HEK2 |
KHD1YBL032W |
|
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
|
|
|
|
|
| EXG1 |
BGL1YLR300W |
|
Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
|
|
|
|
|
| DPH5 |
YLR172C |
|
Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
|
|
|
|
|
| YLR152C |
YLR152C |
|
Putative protein of unknown function; YLR152C is not an essential gene
|
|
|
|
|
| BRE2 |
CPS60YLR015W |
|
Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L
|
|
|
|
|
| MSC1 |
YML128C |
|
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
|
|
|
|
|
| PGA3 |
YML125C |
|
Essential protein required for maturation of Gas1p and Pho8p, protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect
|
|
|
|
|
| HXT2 |
YMR011W |
|
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
|
|
|
|
|
| ATP18 |
YML081C-A |
|
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
|
|
|
|
|
| GIM5 |
PFD5YML094W |
|
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
|
|
|
|
|
| NUP188 |
YML103C |
|
Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
|
|
|
|
|
| SSL1 |
YLR005W |
|
Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
|
|
|
|
|
| RUP2 |
YLL029W |
|
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL029W is not an essential gene but mutant is defective in spore formation
|
|
|
|
|
| SPO12 |
YHR152W |
|
Nucleolar protein of unknown function, positive regulator of exit from mitosis; involved in regulating the release of Cdc14p from the nucleolus in early anaphase; proposed to play similar role in meiosis
|
|
|
|
|
| VID28 |
GID5YIL017WYIL017C |
|
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
|
|
|
|
|
| GPI16 |
YHR188C |
|
Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
|
|
|
|
|
| RRF1 |
KIM4FIL1YHR038W |
|
Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
|
|
|
|
|
| MSS1 |
PET53YMR023C |
|
Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
|
|
|
|
|
| MND2 |
YIR025W |
|
Subunit of the anaphase-promoting complex (APC); needed for meiotic nuclear division
|
|
|
|
|
| BZZ1 |
LSB7YHR114W |
|
SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
|
|
|
|
|
| SRB2 |
HRS2MED20YHR041C |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
|
|
|
|
|
| SWI3 |
TYE2YJL176C |
|
Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
|
|
|
|
|
| PRP21 |
SPP91YJL203W |
|
Subunit of the SF3a splicing factor complex, required for spliceosome assembly
|
|
|
|
|
| IKI1 |
TOT5ELP5HAP2YHR187W |
|
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
|
|
|
|
|
| STB1 |
YNL309W |
|
Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated
|
|
|
|
|
| DFG16 |
ECM41ZRG11YOR030W |
|
Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
|
|
|
|
|
| PET127 |
YOR017W |
|
Protein with a role in mitochondrial RNA stability and/or processing, located in the mitochondrial membrane
|
|
|
|
|
| PAP2 |
TRF4YOL115W |
|
Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase
|
|
|
|
|
| CSE2 |
MED9YNR010W |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity
|
|
|
|
|
| CYC2 |
YOR037W |
|
Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
|
|
|
|
|
| PNT1 |
YOR266W |
|
Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
|
|
|
|
|
| CTR1 |
YPR124W |
|
High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
|
|
|
|
|
| VPS28 |
VPT28YPL065W |
|
Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole
|
|
|
|
|
| KES1 |
BSR3LPI3OSH4YPL145C |
|
Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
|
|
|
|
|
| RIM20 |
YOR275C |
|
Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
|
|
|
|
|
| VPS27 |
GRD11VPL23VPT27YNR006W |
|
Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
|
|
|
|
|
| YNL086W |
YNL086W |
|
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes
|
|
|
|
|
| RIM13 |
CPL1YMR154C |
|
Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB
|
|
|
|
|
| RCO1 |
YMR075W |
|
Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
|
|
|
|
|
| RIM9 |
YMR063W |
|
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
|
|
|
|
|
| STV1 |
YMR054W |
|
Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
|
|
|
|
|
| ARD1 |
YHR013C |
|
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
|
|
|
|
|
| MCK1 |
YPK1YNL307C |
|
Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
|
|
|
|
|
| RAP1 |
GRF1TUF1TBA1YNL216W |
|
DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
|
|
|
|
|
| ALG9 |
YNL219C |
|
Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
|
|
|
|
|
| SIN4 |
GAL22SDI3RYE1YNL236W |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
|
|
|
|
|
| ATX1 |
YNL259C |
|
Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
|
|
|
|
|
| PEX12 |
PAS11YMR026C |
|
C3HC4-type RING-finger peroxisomal membrane peroxin required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorders
|
|
|
|
|
| PDR1 |
AMY1CYH3NRA2YGL013C |
|
Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
|
|
|
|
|
| SCO2 |
YBR024W |
|
Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
|
|
|
|
|
| HAP3 |
YBL021C |
|
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
|
|
|
|
|
| SWD1 |
FUN16CPS50SAF49YAR003W |
|
Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
|
|
|
|
|
| DEP1 |
FUN54YAL013W |
|
Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
|
|
|
|
|
| TAF5 |
TAF90YBR198C |
|
Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
|
|
|
|
|
| BEM1 |
SRO1YBR200W |
|
Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
|
|
|
|
|
| RHB1 |
RSG1YCR027C |
|
Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
|
|
|
|
|
| BIT2 |
YBR270C |
|
Bit2p
|
|
|
|
|
| YBR238C |
YBR238C |
|
Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
|
|
|
|
|
| DER1 |
YBR201W |
|
Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
|
|
|
|
|
| SAC3 |
LEP1YDR159W |
|
Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
|
|
|
|
|
| GIM4 |
PFD2YEL003W |
|
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
|
|
|
|
|
| KNH1 |
YDL049C |
|
Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant
|
|
|
|
|
| FKS1 |
CWH53GSC1PBR1YLR342W |
|
Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
|
|
|
|
|
| CDC8 |
YJR057W |
|
Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
|
|
|
|
|
| CLA4 |
ERC10YNL298W |
|
Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
|
|
|
|
|
| RAD14 |
YMR201C |
|
Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
|
|
|
|
|
| RAD2 |
YGR258C |
|
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
|
|
|
|
|
| PAC10 |
RKS2PFD3GIM2YGR078C |
|
Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
|
|
|
|
|
| RXT2 |
RAF60YBR095C |
|
Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
|
|
|
|
|
| ORC2 |
SIR5RRR1YBR060C |
|
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
|
|
|
|
|
| RAD4 |
YER162C |
|
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
|
|
|
|
|
| PHO13 |
YDL236W |
|
Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
|
|
|
|
|
| BRE1 |
YDL074C |
|
E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain
|
|
|
|
|
| SGF73 |
sca7YGL066W |
|
73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters
|
|
|
|
|
| TAF6 |
TAF60YGL112C |
|
Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
|
|
|
|
|
| SOH1 |
MED31YGL127C |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
|
|
|
|
|
| RTF1 |
CSL3YGL244W |
|
Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
|
|
|
|
|
| RIM8 |
PAL3YGL046WYGL045W |
|
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
|
|
|
|
|
| PEX4 |
UBC10PAS2YGR133W |
|
Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
|
|
|
|
|
| GCN5 |
SWI9ADA4YGR252W |
|
Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
|
|
|
|
|
| PBP1 |
MRS16YGR178C |
|
Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
|
|
|
|
|
| CBP4 |
YGR174C |
|
Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p
|
|
|
|
|
| RTS3 |
YGR161C |
|
Putative component of the protein phosphatase type 2A complex
|
|
|
|
|
| ACT1 |
ABY1END7YFL039C |
|
Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
|
|
|
|
|
| GET2 |
RMD7HUR2YER083C |
|
Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
|
|
|
|
|
| SLU7 |
SLT17YDR088C |
|
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
|
|
|
|
|
| DBF4 |
DNA52LSD7YDR052C |
|
Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated
|
|
|
|
|
| RMD1 |
YDL001W |
|
Cytoplasmic protein required for sporulation
|
|
|
|
|
| GPR1 |
YDL035C |
|
Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
|
|
|
|
|
| YDR124W |
YDR124W |
|
Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
|
|
|
|
|
| OMS1 |
YDR316W |
|
Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
|
|
|
|
|
| CEM1 |
YER061C |
|
Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
|
|
|
|
|
| ANP1 |
MNN8GEM3YEL036C |
|
Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
|
|
|
|
|
| PAU10 |
YDR542W |
|
Pau10p
|
|
|
|
|
| HPT1 |
BRA6YDR399W |
|
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
|
|
|
|
|
| YGR266W |
YGR266W |
|
Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
|
|
|
|
|
