| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| SNF7 |
VPS32DID1RNS4YLR025W |
|
One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
|
|
|
|
|
| DID4 |
VPT14VPS2REN1YKL002W |
|
Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
|
|
|
|
|
| VPS20 |
VPT20CHM6VPL10YMR077C |
|
Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
|
|
|
|
|
| CHS5 |
CAL3YLR330W |
|
Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
|
|
|
|
|
| VPS4 |
END13GRD13VPT10YPR173C |
|
AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism
|
|
|
|
|
| SNF8 |
VPS22YPL002C |
|
Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
|
|
|
|
|
| ACT1 |
ABY1END7YFL039C |
|
Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
|
|
|
|
|
| DOA4 |
NPI2SSV7MUT4YDR069C |
|
Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
|
|
|
|
|
| CDC20 |
PAC5YGL116W |
|
Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
|
|
|
|
|
| RIM9 |
YMR063W |
|
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
|
|
|
|
|
| CHS3 |
CSD2KTI2DIT101YBR023C |
|
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
|
|
|
|
|
| CHO2 |
PEM1YGR157W |
|
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
|
|
|
|
|
| HEK2 |
KHD1YBL032W |
|
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
|
|
|
|
|
| DID2 |
VPS46FTI1CHM1YKR035W-A |
|
Class E protein of the vacuolar protein-sorting (Vps) pathway, associates reversibly with the late endosome, has human ortholog that may be altered in breast tumors
|
|
|
|
|
| VPS24 |
DID3YKL041W |
|
One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
|
|
|
|
|
| SEC22 |
TSL26SLY2YLR268W |
|
R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
|
|
|
|
|
| ICE2 |
YIL090W |
|
Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells
|
|
|
|
|
| ATP14 |
YLR295C |
|
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
|
|
|
|
|
| YJL068C |
YJL068C |
|
Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
|
|
|
|
|
| OPI3 |
PEM2YJR073C |
|
Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
|
|
|
|
|
| ORC3 |
YLL004W |
|
Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
|
|
|
|
|
| FMP27 |
YLR454W |
|
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| SNZ1 |
YMR096W |
|
Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
|
|
|
|
|
| POM152 |
YMR129W |
|
Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase
|
|
|
|
|
| SWP1 |
YMR149W |
|
Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
|
|
|
|
|
| POB3 |
YML069W |
|
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
|
|
|
|
|
| CSM2 |
YIL132C |
|
Protein required for accurate chromosome segregation during meiosis
|
|
|
|
|
| SEC61 |
YLR378C |
|
Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
|
|
|
|
|
| SST2 |
YLR452C |
|
GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
|
|
|
|
|
| ORM2 |
YLR350W |
|
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
|
|
|
|
|
| BUD32 |
LDB14YGR262C |
|
Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
|
|
|
|
|
| PIL1 |
YGR086C |
|
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
|
|
|
|
|
| NUP57 |
YGR119C |
|
Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p
|
|
|
|
|
| YGR012W |
YGR012W |
|
Putative cysteine synthase, localized to the mitochondrial outer membrane
|
|
|
|
|
| MUQ1 |
ECT1YGR007W |
|
Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
|
|
|
|
|
| SEC15 |
YGL233W |
|
Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles
|
|
|
|
|
| PMA1 |
YGL008C |
|
Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases
|
|
|
|
|
| PRE9 |
YGR135W |
|
20S proteasome beta-type subunit; the only nonessential 20S subunit
|
|
|
|
|
| RTS3 |
YGR161C |
|
Putative component of the protein phosphatase type 2A complex
|
|
|
|
|
| NMD2 |
IFS1SUA1UPF2YHR077C |
|
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
|
|
|
|
|
| THP2 |
YHR167W |
|
Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
|
|
|
|
|
| COX6 |
YHR051W |
|
Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
|
|
|
|
|
| SLT2 |
BYC2MPK1SLK2YHR030C |
|
Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
|
|
|
|
|
| QCR9 |
UCR9YGR183C |
|
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
|
|
|
|
|
| CIK1 |
YMR198W |
|
Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
|
|
|
|
|
| RPN10 |
SUN1MCB1YHR200W |
|
Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
|
|
|
|
|
| URE2 |
YNL229C |
|
Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
|
|
|
|
|
| RPT4 |
PCS1CRL13SUG2YOR259C |
|
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle
|
|
|
|
|
| RIM20 |
YOR275C |
|
Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
|
|
|
|
|
| KIN4 |
KIN31KIN3YOR233W |
|
Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck
|
|
|
|
|
| OST2 |
YOR103C |
|
Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
|
|
|
|
|
| DFG16 |
ECM41ZRG11YOR030W |
|
Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
|
|
|
|
|
| SHE4 |
DIM1YOR035C |
|
Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
|
|
|
|
|
| SLY41 |
YOR307C |
|
Protein involved in ER-to-Golgi transport
|
|
|
|
|
| HSD1 |
YOR311C |
|
Endoplasmic reticulum (ER)-resident membrane protein, overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation
|
|
|
|
|
| MNI2 |
YPR045C |
|
Deletion mutant is synthetically lethal with MEN mutants
|
|
|
|
|
| SGE1 |
NOR1YPR198W |
|
Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
|
|
|
|
|
| SUV3 |
LPB2YPL029W |
|
ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
|
|
|
|
|
| KES1 |
BSR3LPI3OSH4YPL145C |
|
Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
|
|
|
|
|
| SAM4 |
YPL273W |
|
S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
|
|
|
|
|
| COX10 |
YPL172C |
|
Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
|
|
|
|
|
| INO4 |
YOL108C |
|
Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
|
|
|
|
|
| GRE2 |
YOL151W |
|
NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
|
|
|
|
|
| SIN4 |
GAL22SDI3RYE1YNL236W |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
|
|
|
|
|
| RPN12 |
NIN1YFR052W |
|
Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
|
|
|
|
|
| ATP11 |
YNL315C |
|
Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
|
|
|
|
|
| LCB1 |
TSC2END8YMR296C |
|
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
|
|
|
|
|
| ERG8 |
YMR220W |
|
Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
|
|
|
|
|
| COX7 |
YMR256C |
|
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
|
|
|
|
|
| ALG9 |
YNL219C |
|
Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
|
|
|
|
|
| DCP2 |
PSU1YNL118C |
|
Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
|
|
|
|
|
| BRE5 |
YNR051C |
|
Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
|
|
|
|
|
| HXT17 |
YNR072W |
|
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
|
|
|
|
|
| HUB1 |
YNR032C-A |
|
Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
|
|
|
|
|
| MRPL50 |
YNR022C |
|
Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
|
|
|
|
|
| YNL010W |
YNL010W |
|
Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
|
|
|
|
|
| VPS27 |
GRD11VPL23VPT27YNR006W |
|
Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
|
|
|
|
|
| SCJ1 |
YMR214W |
|
One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
|
|
|
|
|
| PAU10 |
YDR542W |
|
Pau10p
|
|
|
|
|
| PMR1 |
BSD1SSC1LDB1YGL167C |
|
High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
|
|
|
|
|
| YPT6 |
YLR262C |
|
GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
|
|
|
|
|
| UBP3 |
YER151C |
|
Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin
|
|
|
|
|
| HSC82 |
HSP90YMR186W |
|
Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
|
|
|
|
|
| YNG2 |
EAF4NBN1YHR090C |
|
Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1
|
|
|
|
|
| HSP82 |
HSP90YPL240C |
|
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
|
|
|
|
|
| PHO85 |
LDB15YPL031C |
|
Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5
|
|
|
|
|
| SIF2 |
EMB1YBR103W |
|
WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
|
|
|
|
|
| YKU80 |
HDF2YMR106C |
|
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
|
|
|
|
|
| ERV46 |
FUN9YAL042W |
|
Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
|
|
|
|
|
| INP52 |
SJL2YNL106C |
|
Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
|
|
|
|
|
| SGF73 |
sca7YGL066W |
|
73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters
|
|
|
|
|
| SUR1 |
LPE15CSG1BCL21YPL057C |
|
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
|
|
|
|
|
| WHI2 |
YOR043W |
|
Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
|
|
|
|
|
| SWC4 |
GOD1EAF2YGR002C |
|
Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
|
|
|
|
|
| EAF1 |
VID21YDR359C |
|
Component of the NuA4 histone acetyltransferase complex
|
|
|
|
|
| CNB1 |
YCN2CRV1YKL190W |
|
Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
|
|
|
|
|
| CCR4 |
FUN27NUT21YAL021C |
|
Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
|
|
|
|
|
| KRE6 |
CWH48YPR159W |
|
Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p
|
|
|
|
|
| KRE11 |
TRS65YGR166W |
|
Protein involved in biosynthesis of cell wall beta-glucans; subunit of the TRAPP (transport protein particle) complex, which is involved in the late steps of endoplasmic reticulum to Golgi transport
|
|
|
|
|
| HKR1 |
YDR420W |
|
Serine/threonine rich cell surface protein; osmosensor; involved in the regulation of cell wall beta-1,3 glucan synthesis, bud site selection and hyperosmotic response; overexpression confers resistance to Hansenula mrakii killer toxin HM-1
|
|
|
|
|
| HOG1 |
SSK3YLR113W |
|
Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
|
|
|
|
|
| POP2 |
CAF1YNR052C |
|
RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
|
|
|
|
|
| RPN4 |
UFD5SON1YDL020C |
|
Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
|
|
|
|
|
| YPP1 |
YGR198W |
|
Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
|
|
|
|
|
| ARP4 |
ACT3YJL081C |
|
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
|
|
|
|
|
| VPS28 |
VPT28YPL065W |
|
Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; involved in transport of precursors for soluble vacuolar hydrolases from the late endosome to the vacuole
|
|
|
|
|
| STP22 |
VPS23YCL008C |
|
Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
|
|
|
|
|
| RIM8 |
PAL3YGL046WYGL045W |
|
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
|
|
|
|
|
| RIM21 |
PAL2YNL294C |
|
Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH
|
|
|
|
|
| DEP1 |
FUN54YAL013W |
|
Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
|
|
|
|
|
| SSA3 |
YG106YBL075C |
|
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
|
|
|
|
|
| GPI8 |
YDR331W |
|
ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
|
|
|
|
|
| DIT2 |
CYP56YDR402C |
|
N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s
|
|
|
|
|
| SSD1 |
CLA1MCS1SRK1YDR293C |
|
Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
|
|
|
|
|
| SRP101 |
YDR292C |
|
Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
|
|
|
|
|
| PMP3 |
SNA1YDR276C |
|
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
|
|
|
|
|
| GCN2 |
AAS1YDR283C |
|
Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex
|
|
|
|
|
| ERD1 |
LDB2YDR414C |
|
Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
|
|
|
|
|
| POL5 |
YEL055C |
|
DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
|
|
|
|
|
| MET6 |
YER091C |
|
Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
|
|
|
|
|
| SCS2 |
YER120W |
|
Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
|
|
|
|
|
| PTP3 |
YER075C |
|
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
|
|
|
|
|
| WBP1 |
YEL002C |
|
Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum
|
|
|
|
|
| SPF1 |
COD1PER9PIO1YEL031W |
|
P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
|
|
|
|
|
| CUP5 |
VMA3CLS7GEF2YEL027W |
|
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
|
|
|
|
|
| HTA1 |
H2A1SPT11YDR225W |
|
One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
|
|
|
|
|
| CDC37 |
SMO1YDR168W |
|
Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
|
|
|
|
|
| VMA9 |
LDB10CWH36YCL005W-A |
|
Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis
|
|
|
|
|
| CDC10 |
YCR002C |
|
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
|
|
|
|
|
| DPB3 |
YBR278W |
|
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle
|
|
|
|
|
| YBR235W |
YBR235W |
|
Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
|
|
|
|
|
| ARL1 |
DLP2YBR164C |
|
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
|
|
|
|
|
| SEC66 |
HSS1SEC71YBR171W |
|
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
|
|
|
|
|
| SNT1 |
YCR033W |
|
Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein
|
|
|
|
|
| SOR2 |
YDL246C |
|
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
|
|
|
|
|
| TPS2 |
PFK3HOG2YDR074W |
|
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
|
|
|
|
|
| KGD2 |
YDR148C |
|
Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
|
|
|
|
|
| RAD57 |
YDR004W |
|
Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
|
|
|
|
|
| TSC13 |
YDL015C |
|
Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
|
|
|
|
|
| COP1 |
SEC33RET1SOO1YDL145C |
|
Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
|
|
|
|
|
| UBX3 |
YDL091C |
|
UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
|
|
|
|
|
| UBP6 |
YFR010W |
|
Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
|
|
|
|
|
