The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for SPC42 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

SPC42

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YKL042W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane|Spc42p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SPC42

SPC42 was identified with 45 protein interactions and 8 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SPC42
  • YKL042W
    		•  The BioGRID Database Seperator Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane|Spc42p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Elliott S (1999)
    bait/hit Adams IR (1999)
    bait/hit Newman JR (2000)
    FRET
    bait/hit Muller EG (2005)
    Co-crystal Structure
    hit Zizlsperger N (2008)
    Reconstituted Complex
    hit Zizlsperger N (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC110
  • NUF1
  • XCM1
  • YDR356W
    		•  The BioGRID Database Seperator Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner|Spc110p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Elliott S (1999)
    bait Knop M (1997)
    Two-hybrid
    bait/hit Adams IR (1999)
    FRET
    bait/hit Muller EG (2005)
    Reconstituted Complex
    bait Vinh DB (2002)
    Co-purification
    bait Wigge PA (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC29
  • LPH3
  • NIP29
  • YPL124W
    		•  The BioGRID Database Seperator Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication|Spc29p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Elliott S (1999)
    FRET
    bait/hit Muller EG (2005)
    Dosage Lethality
    bait Elliott S (1999)
    Dosage Rescue
    hit Elliott S (1999)
    Synthetic Lethality
    hit Elliott S (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS1
  • RPK1
  • YDL028C
    		•  The BioGRID Database Seperator Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p|Mps1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Castillo AR (2002)
    Biochemical Activity
    bait Castillo AR (2002)
    Dosage Rescue
    bait Castillo AR (2002)
    Synthetic Lethality
    hit Castillo AR (2002)
    Synthetic Growth Defect
    hit Jaspersen SL (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CNM67
  • YNL225C
    		•  The BioGRID Database Seperator Cnm67p|Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Elliott S (1999)
    bait/hit Adams IR (1999)
    FRET
    bait/hit Muller EG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLP2
  • YIL149C
    		•  The BioGRID Database Seperator Mlp2p|Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Niepel M (2005)
    Affinity Capture-Western
    hit Niepel M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB5
  • YPR120C
    		•  The BioGRID Database Seperator B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase|Clb5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Archambault V (2004)
    Two-hybrid
    bait Maekawa H (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK1
  • CKI2
  • YHR135C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p|Yck1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NFI1
  • SIZ2
  • YOR156C
    		•  The BioGRID Database Seperator Nfi1p|SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK1
  • PKA1
  • SRA3
  • YJL164C
    		•  The BioGRID Database Seperator Tpk1p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOS3
  • YGL179C
    		•  The BioGRID Database Seperator Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome|Tos3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP43
  • YGL120C
    		•  The BioGRID Database Seperator Prp43p|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Lebaron S (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIS1
  • JIP1
  • YNL078W
    		•  The BioGRID Database Seperator Nis1p|Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWE1
  • WEE1
  • YJL187C
    		•  The BioGRID Database Seperator Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate|Swe1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC19
  • YDR201W
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body|Spc19p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC9
  • YDL064W
    		•  The BioGRID Database Seperator SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)|Ubc9p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEX3
  • SLX5
  • YDL013W
    		•  The BioGRID Database Seperator Slx5p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CMK1
  • YFR014C
    		•  The BioGRID Database Seperator Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II|Cmk1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • HSL5
  • SRM5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates|Cdc28p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Maekawa H (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPO21
  • MPC70
  • YOL091W
    		•  The BioGRID Database Seperator Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation|Spo21p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Knop M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADY3
  • YDL239C
    		•  The BioGRID Database Seperator Ady3p|Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Nickas ME (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUD1
  • YOR373W
    		•  The BioGRID Database Seperator Component of the spindle pole body outer plaque, required for exit from mitosis|Nud1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Elliott S (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • STK2
  • YJR059W
    		•  The BioGRID Database Seperator Ptk2p|Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC1
  • CHL10
  • YFL008W
    		•  The BioGRID Database Seperator Smc1p|Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Newman JR (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • AGS3
  • TUP7
  • VAC5
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance|Pho80p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUF2
  • YOL069W
    		•  The BioGRID Database Seperator Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering|Nuf2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Newman JR (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG1
  • APG1
  • AUT3
  • CVT10
  • YGL180W
    		•  The BioGRID Database Seperator Atg1p|Protein serine/threonine kinase, required for autophagy and for the cytoplasm-to-vacuole targeting (Cvt) pathway; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CMD1
  • YBR109C
    		•  The BioGRID Database Seperator Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin|Cmd1p; protein coding
    Gene Ontology: [View List]
    FRET
    bait/hit Muller EG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NBP1
  • YLR457C
    		•  The BioGRID Database Seperator Nbp1p|Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Araki Y (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS3
  • NEP98
  • YJL018W
  • YJL019W
    		•  The BioGRID Database Seperator Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p|Mps3p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Jaspersen SL (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.