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BioGRID | Network Layout for YKT6 for Saccharomyces cerevisiae
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YKT6

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YKL196C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 15 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with YKT6

YKT6 was identified with 83 protein interactions and 16 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 VTI1
  • YMR197C
    		•  The BioGRID Database Seperator Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Ungermann C (1999) [22]
    bait Lupashin VV (1997) [10]
    bait Laage R (2001) [6]
    bait Dietrich LE (2005) [4]
    bait Collins KM (2005) [62]
    Reconstituted Complex
    bait Tsui MM (2001) [28]
    bait Tsui MM (2000) [33]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Co-purification
    bait Collins KM (2005) [62]
    Dosage Rescue
    bait Lupashin VV (1997) [10]
    bait Dilcher M (2001) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM3
  • PTH1
  • YOR106W
    		•  The BioGRID Database Seperator Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wang Y (2001) [5]
    bait/hit Price A (2000) [12]
    bait/hit Ungermann C (1999) [22]
    bait Rohde J (2003) [3]
    hit Dietrich LE (2005) [4]
    bait Collins KM (2005) [62]
    Co-purification
    bait Ungermann C (1999) [22]
    Two-hybrid
    hit Zhang H (2009) [71]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SED5
  • YLR026C
    		•  The BioGRID Database Seperator cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait McNew JA (1997) [3]
    bait Parlati F (2002) [15]
    Reconstituted Complex
    bait/hit Tsui MM (2001) [28]
    bait/hit Tsui MM (2000) [33]
    hit Peng R (2002) [33]
    Co-purification
    bait Inadome H (2005) [78]
    Two-hybrid
    hit Zhang H (2009) [71]
    Synthetic Rescue
    bait Graf CT (2005) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC17
  • RNS3
  • YBL050W
    		•  The BioGRID Database Seperator Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Burri L (2003) [7]
    hit Ungermann C (1999) [22]
    bait Dietrich LE (2005) [4]
    hit Schindler C (2007) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP12
  • VPT13
  • VPL6
  • VPS6
  • YOR036W
    		•  The BioGRID Database Seperator Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lewis MJ (2002) [8]
    Reconstituted Complex
    hit Tsui MM (2000) [33]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GOS1
  • YHL031C
    		•  The BioGRID Database Seperator v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Parlati F (2002) [15]
    Reconstituted Complex
    bait Tsui MM (2000) [33]
    bait Tsui MM (2001) [28]
    Synthetic Lethality
    bait Tsui MM (2000) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BET1
  • SLY12
  • YIL004C
    		•  The BioGRID Database Seperator Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
    Gene Ontology: [View List]
    Reconstituted Complex
    bait/hit Tsui MM (2001) [28]
    bait/hit Tsui MM (2000) [33]
    hit Peng R (2002) [33]
    Synthetic Rescue
    bait Graf CT (2005) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFT1
  • YKL006C-A
    		•  The BioGRID Database Seperator Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Tsui MM (2001) [28]
    bait Tsui MM (2000) [33]
    Dosage Rescue
    hit Kweon Y (2003) [2]
    hit Tsui MM (2000) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC22
  • TSL26
  • SLY2
  • YLR268W
    		•  The BioGRID Database Seperator R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Peng R (2002) [33]
    bait/hit Tsui MM (2000) [33]
    Synthetic Lethality
    hit Liu Y (2002) [1]
    Synthetic Rescue
    bait Graf CT (2005) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM7
  • VPS43
  • YGL212W
    		•  The BioGRID Database Seperator Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ungermann C (1999) [22]
    bait Collins KM (2005) [62]
    Co-purification
    bait Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     USE1
  • SLT1
  • YGL098W
    		•  The BioGRID Database Seperator Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Burri L (2003) [7]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NYV1
  • MAM2
  • YLR093C
    		•  The BioGRID Database Seperator v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Price A (2000) [12]
    hit Ungermann C (1999) [22]
    Dosage Rescue
    hit Kweon Y (2003) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC8
  • YEB3
  • YEL013W
    		•  The BioGRID Database Seperator Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
    Gene Ontology: [View List]
    Reconstituted Complex
    bait/hit Dietrich LE (2004) [2]
    hit Dietrich LE (2004) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC39
  • YLR440C
    		•  The BioGRID Database Seperator Protein of unknown function proposed to be involved in protein secretion; interacts with Dsl1p and localizes to the ER and nuclear envelope
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSO1
  • YPL232W
    		•  The BioGRID Database Seperator Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
    Gene Ontology: [View List]
    FRET
    hit Zhang H (2009) [71]
    Two-hybrid
    hit Zhang H (2009) [71]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLY1
  • YDR189W
    		•  The BioGRID Database Seperator Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    Reconstituted Complex
    hit Peng R (2004) [13]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKT6
  • YKL196C
    		•  The BioGRID Database Seperator Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Tsui MM (2000) [33]
    Co-crystal Structure
    hit Pylypenko O (2008) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG3
  • SEC34
  • GRD20
  • YER157W
    		•  The BioGRID Database Seperator Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Suvorova ES (2002) [29]
    Dosage Rescue
    bait VanRheenen SM (1999) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF1
  • YDL192W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Schindler C (2007) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Isgandarova S (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSL1
  • RNS1
  • YNL258C
    		•  The BioGRID Database Seperator Peripheral membrane protein required for Golgi-to-ER retrograde traffic; component of the ER target site that interacts with coatomer, the major component of the COPI vesicle protein coat; also interacts with Cin5p and Sec39p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIP20
  • TIP1
  • YGL145W
    		•  The BioGRID Database Seperator Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC18
  • ANU4
  • YBR080C
    		•  The BioGRID Database Seperator ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Schindler C (2007) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSO2
  • YMR183C
    		•  The BioGRID Database Seperator Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Zhang H (2009) [71]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Co-fractionation
    bait Xu H (2006) [20]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STM1
  • MPT4
  • YLR150W
    		•  The BioGRID Database Seperator Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Van Dyke MW (2004) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS41
  • VAM2
  • CVT8
  • SVL2
  • YDR080W
    		•  The BioGRID Database Seperator Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Price A (2000) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS33
  • CLS14
  • SLP1
  • VAM5
  • YLR396C
    		•  The BioGRID Database Seperator ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
    Gene Ontology: [View List]
    Co-purification
    bait Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS45
  • VPL28
  • STT10
  • YGL095C
    		•  The BioGRID Database Seperator Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URA7
  • YBL039C
    		•  The BioGRID Database Seperator Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOS1
  • SEC32
  • YLR078C
    		•  The BioGRID Database Seperator v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
    Gene Ontology: [View List]
    Reconstituted Complex
    bait/hit Tsui MM (2000) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYN8
  • SLT2
  • UIP2
  • YAL014C
    		•  The BioGRID Database Seperator Endosomal SNARE related to mammalian syntaxin 8
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lewis MJ (2002) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UIP3
  • YAR027W
    		•  The BioGRID Database Seperator Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005) [1977]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM6
  • VPL22
  • VPS39
  • CVT4
  • YDL077C
    		•  The BioGRID Database Seperator Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
    Gene Ontology: [View List]
    Co-purification
    bait Collins KM (2005) [62]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TLG2
  • YOL018C
    		•  The BioGRID Database Seperator Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation
    Gene Ontology: [View List]
    Co-purification
    bait Inadome H (2005) [78]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AKR1
  • YDR264C
    		•  The BioGRID Database Seperator Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNC2
  • YOR327C
    		•  The BioGRID Database Seperator Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
    Gene Ontology: [View List]
    Dosage Rescue
    hit Tsui MM (2000) [33]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     USO1
  • INT1
  • YDL058W
    		•  The BioGRID Database Seperator Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex
    Gene Ontology: [View List]
    Dosage Rescue
    bait Sapperstein SK (1996) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIC1
  • YLR039C
    		•  The BioGRID Database Seperator Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
    Gene Ontology: [View List]
    Dosage Rescue
    bait Bensen ES (2001) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
    Gene Ontology: [View List]
    Dosage Rescue
    bait Bensen ES (2001) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG2
  • SEC35
  • YGR120C
    		•  The BioGRID Database Seperator Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
    Gene Ontology: [View List]
    Dosage Rescue
    bait VanRheenen SM (1998) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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