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BioGRID | Network Layout for JSN1 for Saccharomyces cerevisiae
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JSN1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: PUF1, YJR091C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Jsn1p|Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with JSN1

JSN1 was identified with 32 protein interactions and 17 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RBL2
  • YOR265W
    		•  The BioGRID Database Seperator Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A|Rbl2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT2
  • NOT4
  • SIG1
  • YER068W
    		•  The BioGRID Database Seperator Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)|Mot2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008) [2616]
    Phenotypic Enhancement
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB2
  • ARM10
  • SHE8
  • YFL037W
    		•  The BioGRID Database Seperator Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules|Tub2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Machin NA (1995) [1]
    bait Machin NA (1996) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR392C
  • YLR392C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR392C is not an essential gene|Ylr392cp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEX3
  • SLX5
  • YDL013W
    		•  The BioGRID Database Seperator Slx5p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIS1
  • MDV2
  • YIL065C
    		•  The BioGRID Database Seperator Fis1p|Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC34
  • YKR037C
    		•  The BioGRID Database Seperator Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body|Spc34p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR2
  • CYP2
  • YHR057C
    		•  The BioGRID Database Seperator Cpr2p|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome|Clb2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJL107C
  • YJL107C
    		•  The BioGRID Database Seperator Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi|Yjl107cp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator Hek2p|RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length; protein coding
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait/hit Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF1
  • YKR059W
    		•  The BioGRID Database Seperator Tif1p|Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein coding
    Gene Ontology: [View List]
    Protein-RNA
    hit Ulbricht RJ (2008) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXK1
  • YFR053C
    		•  The BioGRID Database Seperator Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p|Hxk1p; protein coding
    Gene Ontology: [View List]
    Protein-RNA
    hit Ulbricht RJ (2008) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PET20
  • YPL159C
    		•  The BioGRID Database Seperator Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome|Pet20p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • HSL5
  • SRM5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates|Cdc28p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC18
  • YLR370C
    		•  The BioGRID Database Seperator Arc18p|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Fehrenbacher KL (2005) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPA1
  • VMA16
  • YHR026W
    		•  The BioGRID Database Seperator Ppa1p|Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DID4
  • CHM2
  • GRD7
  • REN1
  • YKL002W
    		•  The BioGRID Database Seperator Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis|Did4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC26
  • HIT3
  • SCD26
  • YFR036W
    		•  The BioGRID Database Seperator Cdc26p|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC8
  • YEB3
  • YEL013W
    		•  The BioGRID Database Seperator Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions|Vac8p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAA1
  • YOR317W
    		•  The BioGRID Database Seperator Faa1p|Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC7
  • YDR389W
    		•  The BioGRID Database Seperator GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate|Sac7p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD27
  • ERC11
  • RTH1
  • FEN1
  • YKL113C
    		•  The BioGRID Database Seperator 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family|Rad27p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN5
  • NAS5
  • YDL147W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p|Rpn5p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNR048W
  • CRF1
    		•  The BioGRID Database Seperator Protein proposed to interact with phospholipid translocases, shares similarity to Cdc50p|Ynr048wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REX2
  • YNT20
  • YLR059C
    		•  The BioGRID Database Seperator RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases|Rex2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX4
  • CUI1
  • YMR067C
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p|Ubx4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTS1
  • SCS1
  • YOR014W
    		•  The BioGRID Database Seperator B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A|Rts1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR156W
  • YLR156W
    		•  The BioGRID Database Seperator Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis|Ylr156wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URA4
  • YLR420W
    		•  The BioGRID Database Seperator Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate|Ura4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF11
  • TAF40
  • YML015C
    		•  The BioGRID Database Seperator TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors|Taf11p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ito T (2001) [785]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSM4
  • DOA10
  • KIS3
  • YIL030C
    		•  The BioGRID Database Seperator Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRF4
  • PAP2
  • YOL115W
    		•  The BioGRID Database Seperator Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase|Pap2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UAF30
  • YOR295W
    		•  The BioGRID Database Seperator Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate|Uaf30p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUS1
  • YMR240C
    		•  The BioGRID Database Seperator Cus1p|Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLP1
  • MPL1
  • YKR095W
    		•  The BioGRID Database Seperator Mlp1p|Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP30
  • YMR263W
    		•  The BioGRID Database Seperator Sap30p|Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAF1
  • YIL019W
    		•  The BioGRID Database Seperator Faf1p|Protein required for pre-rRNA processing and 40S ribosomal subunit assembly; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ANB1
  • HYP1
  • TIF51B
  • YJR047C
    		•  The BioGRID Database Seperator Anb1p|Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HCR1
  • YLR192C
    		•  The BioGRID Database Seperator Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA|Hcr1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPT5
  • HTR1
  • PUF5
  • UTH4
  • YGL178W
    		•  The BioGRID Database Seperator Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest|Mpt5p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Ulbricht RJ (2008) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO21
  • RPB1
  • RPB220
  • SUA8
  • YDL140C
    		•  The BioGRID Database Seperator RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime|Rpo21p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM5
  • PFD5
  • YML094W
    		•  The BioGRID Database Seperator Gim5p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR269W
  • YMR268W-A
  • TMA23
    		•  The BioGRID Database Seperator Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes|Tma23p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTV1
  • YKL2
  • YKL143W
    		•  The BioGRID Database Seperator Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature|Ltv1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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