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BioGRID | Network Layout for RFC2 for Saccharomyces cerevisiae
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RFC2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YJR068W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RFC2

RFC2 was identified with 75 protein interactions and 8 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RFC3
  • YNL290W
    		•  The BioGRID Database Seperator Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Naiki T (2000) [4]
    Reconstituted Complex
    hit Yao N (2003) [7]
    Co-purification
    hit Gerik KJ (1997) [9]
    hit Yao N (2003) [7]
    hit Ionescu CN (2002) [4]
    hit Schmidt SL (2001) [4]
    PCA
    hit Tarassov K (2008) [2616]
    Two-hybrid
    hit Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFC5
  • YBR087W
    		•  The BioGRID Database Seperator Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Yao N (2003) [7]
    Affinity Capture-Western
    bait Shimomura T (1998) [6]
    Co-purification
    hit Gerik KJ (1997) [9]
    hit Yao N (2003) [7]
    hit Ionescu CN (2002) [4]
    hit Schmidt SL (2001) [4]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Collins SR (2007) [9064]
    Two-hybrid
    bait Yu H (2008) [1778]
    Synthetic Lethality
    bait Davierwala AP (2005) [564]
    hit Noskov VN (1998) [5]
    Dosage Rescue
    hit Noskov VN (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFC4
  • YOL094C
    		•  The BioGRID Database Seperator Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait/hit Ho Y (2002) [3666]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Co-purification
    hit Gerik KJ (1997) [9]
    hit Yao N (2003) [7]
    hit Ionescu CN (2002) [4]
    hit Schmidt SL (2001) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFC1
  • CDC44
  • YOR217W
    		•  The BioGRID Database Seperator Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
    Gene Ontology: [View List]
    Co-purification
    hit Gerik KJ (1997) [9]
    hit Yao N (2003) [7]
    hit Ionescu CN (2002) [4]
    hit Schmidt SL (2001) [4]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Synthetic Lethality
    hit Noskov VN (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD24
  • YER173W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Affinity Capture-Western
    bait/hit Green CM (2000) [10]
    hit Shimomura T (1998) [6]
    Reconstituted Complex
    bait Majka J (2003) [6]
    bait Green CM (2000) [10]
    Co-purification
    bait Majka J (2004) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Naiki T (2001) [9]
    bait Hanna JS (2001) [9]
    Reconstituted Complex
    bait Bylund GO (2005) [7]
    Co-purification
    bait Bylund GO (2006) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELG1
  • RTT110
  • YOR144C
    		•  The BioGRID Database Seperator Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Bellaoui M (2003) [57]
    hit Kanellis P (2003) [14]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL30
  • YBR088C
    		•  The BioGRID Database Seperator Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Gerik KJ (1997) [9]
    bait Yao NY (2006) [2]
    Synthetic Rescue
    bait Amin NS (1999) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Franco AA (2005) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS0B
  • YST2
  • YLR048W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA2
  • H2A2
  • YBL003C
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lambert JP (2009) [269]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YTA7
  • YGR270W
    		•  The BioGRID Database Seperator Protein of unknown function, member of CDC48/PAS1/SEC18 family of ATPases, potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lambert JP (2009) [269]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS3
  • NEP98
  • YJL018W
  • YJL019W
    		•  The BioGRID Database Seperator Essential integral membrane protein required for spindle pole body duplication and for nuclear fusion, localizes to the spindle pole body half bridge, interacts with DnaJ-like chaperone Jem1p and with centrin homolog Cdc31p
    Gene Ontology: [View List]
    Two-hybrid
    hit Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IVY1
  • YDR229W
    		•  The BioGRID Database Seperator Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
    Gene Ontology: [View List]
    Two-hybrid
    hit Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECO1
  • CTF7
  • YFR027W
    		•  The BioGRID Database Seperator Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Kenna MA (2003) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC9
  • MMS8
  • YDL164C
    		•  The BioGRID Database Seperator DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Vijayakumar S (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMD3
  • YLR432W
    		•  The BioGRID Database Seperator Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF8
  • YHR191C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Mayer ML (2001) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRR2
  • SNU246
  • SLT22
  • PRP44
  • YER172C
    		•  The BioGRID Database Seperator RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTG1
  • SCR1
  • FUN33
  • YAL015C
    		•  The BioGRID Database Seperator DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus and mitochondrion
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEF3
  • ZRG7
  • YNL014W
    		•  The BioGRID Database Seperator Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADE5,7
  • YGL234W
    		•  The BioGRID Database Seperator Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPA2
  • YJR109C
    		•  The BioGRID Database Seperator Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PGM2
  • GAL5
  • YMR105C
    		•  The BioGRID Database Seperator Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP3
  • YBR039W
    		•  The BioGRID Database Seperator Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDH2
  • YOL126C
    		•  The BioGRID Database Seperator Cytoplasmic malate dehydrogenase, one of the three isozymes that catalyze interconversion of malate and oxaloacetate; involved in gluconeogenesis during growth on ethanol or acetate as carbon source; interacts with Pck1p and Fbp1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC8
  • YEB3
  • YEL013W
    		•  The BioGRID Database Seperator Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ROM2
  • YLR371W
    		•  The BioGRID Database Seperator GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACH1
  • YBL015W
    		•  The BioGRID Database Seperator Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRP1
  • KAP60
  • SCM1
  • YNL189W
    		•  The BioGRID Database Seperator Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL2
  • DUN2
  • YNL262W
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase (II) epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Noskov VN (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Davierwala AP (2005) [564]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL3
  • HPR6
  • CDC2
  • TEX1
  • YDL102W
    		•  The BioGRID Database Seperator Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Noskov VN (1998) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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