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BioGRID | Network Layout for TOR1 for Saccharomyces cerevisiae
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TOR1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: DRR1, YJR066W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 24 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with TOR1

TOR1 was identified with 96 protein interactions and 145 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 KOG1
  • LAS24
  • YHR186C
    		•  The BioGRID Database Seperator Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Wedaman KP (2003) [11]
    bait/hit Loewith R (2002) [21]
    hit Reinke A (2006) [1]
    hit Nakashima A (2008) [9]
    bait Ho HL (2008) [24]
    bait Kamada Y (2009) [5]
    Affinity Capture-MS
    bait/hit Reinke A (2004) [27]
    Co-purification
    hit Adami A (2007) [1]
    hit Wanke V (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LST8
  • YNL006W
    		•  The BioGRID Database Seperator Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Chen EJ (2003) [6]
    bait Wedaman KP (2003) [11]
    bait/hit Loewith R (2002) [21]
    bait Ho HL (2008) [24]
    Affinity Capture-MS
    bait/hit Reinke A (2004) [27]
    Co-purification
    hit Wanke V (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TCO89
  • YPL180W
    		•  The BioGRID Database Seperator Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Reinke A (2004) [27]
    Affinity Capture-MS
    hit Reinke A (2004) [27]
    Co-purification
    hit Wanke V (2008) [6]
    Synthetic Lethality
    hit Reinke A (2004) [27]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCH9
  • KOM1
  • YHR205W
    		•  The BioGRID Database Seperator Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB
    Gene Ontology: [View List]
    Biochemical Activity
    hit Urban J (2007) [1]
    hit Wanke V (2008) [6]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    Synthetic Rescue
    hit Wei M (2009) [11]
    Phenotypic Suppression
    bait/hit Wei M (2009) [11]
    Phenotypic Enhancement
    bait Wei M (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR2
  • DRR2
  • YKL203C
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
    Gene Ontology: [View List]
    Co-purification
    bait Wedaman KP (2003) [11]
    Phenotypic Enhancement
    hit Helliwell SB (1994) [1]
    Dosage Rescue
    hit Reinke A (2004) [27]
    Synthetic Growth Defect
    bait DeLuna A (2008) [73]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLM4
  • EGO3
  • GSE1
  • NIR1
  • YBR077C
    		•  The BioGRID Database Seperator Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Huang J (2004) [3]
    Synthetic Growth Defect
    bait Huang J (2004) [3]
    hit Zurita-Martinez SA (2007) [14]
    Phenotypic Enhancement
    bait Huang J (2004) [3]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLT2
  • BYC2
  • MPK1
  • SLK2
  • YHR030C
    		•  The BioGRID Database Seperator Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    Synthetic Lethality
    bait Torres J (2002) [1]
    hit Aronova S (2007) [124]
    Dosage Rescue
    hit Reinke A (2004) [27]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAP42
  • YMR028W
    		•  The BioGRID Database Seperator Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
    Gene Ontology: [View List]
    Co-purification
    bait Yan G (2006) [7]
    Affinity Capture-Western
    bait Kuepfer L (2007) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLN3
  • YER040W
    		•  The BioGRID Database Seperator Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Carvalho J (2003) [6]
    hit Bertram PG (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIK1
  • ARM5
  • PAC14
  • YCL029C
    		•  The BioGRID Database Seperator Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
    Gene Ontology: [View List]
    Two-hybrid
    bait Choi JH (2000) [3]
    Affinity Capture-Western
    bait/hit Choi JH (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FPR1
  • RBP1
  • FKB1
  • YNL135C
    		•  The BioGRID Database Seperator Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Neklesa TK (2008) [5]
    Reconstituted Complex
    bait Neklesa TK (2008) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
    Gene Ontology: [View List]
    Negative Genetic
    hit Wilmes GM (2008) [6467]
    hit Fiedler D (2009) [4053]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC8
  • YEB3
  • YEL013W
    		•  The BioGRID Database Seperator Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Schuldiner M (2005) [6832]
    Synthetic Growth Defect
    hit Zurita-Martinez SA (2007) [14]
    Phenotypic Enhancement
    bait Tang F (2008) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTG2
  • YGL252C
    		•  The BioGRID Database Seperator Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    hit Jin R (2008) [6]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM6
  • VPL22
  • VPS39
  • CVT4
  • YDL077C
    		•  The BioGRID Database Seperator Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Zurita-Martinez SA (2007) [14]
    Synthetic Rescue
    bait Binda M (2009) [13]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTR1
  • YML121W
    		•  The BioGRID Database Seperator Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Zurita-Martinez SA (2007) [14]
    Synthetic Rescue
    bait Binda M (2009) [13]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFP1
  • YLR403W
    		•  The BioGRID Database Seperator Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lempiaeinen H (2009) [16]
    Phenotypic Suppression
    bait Hosiner D (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHE4
  • DIM1
  • YOR035C
    		•  The BioGRID Database Seperator Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    Synthetic Growth Defect
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRV2
  • CAP
  • YNL138W
    		•  The BioGRID Database Seperator CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    Synthetic Lethality
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPK1
  • SLI2
  • YKL126W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    Synthetic Growth Defect
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA2
  • END4
  • MOP2
  • YNL243W
    		•  The BioGRID Database Seperator Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    Synthetic Lethality
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC6
  • ABP67
  • YDR129C
    		•  The BioGRID Database Seperator Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    Synthetic Lethality
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URE2
  • YNL229C
    		•  The BioGRID Database Seperator Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000) [9]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM2
  • IPL2
  • SUP9
  • TSL1
  • YER155C
    		•  The BioGRID Database Seperator Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    Synthetic Lethality
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAS2
  • CYR3
  • CTN5
  • TSL7
  • YNL098C
    		•  The BioGRID Database Seperator GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wei M (2009) [11]
    Phenotypic Enhancement
    hit Wei M (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS41
  • VAM2
  • CVT8
  • SVL2
  • YDR080W
    		•  The BioGRID Database Seperator Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Zurita-Martinez SA (2007) [14]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC17
  • YCL062W
  • YCL063W
    		•  The BioGRID Database Seperator Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Zurita-Martinez SA (2007) [14]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN4
  • ARG9
  • AAS3
  • YEL009C
    		•  The BioGRID Database Seperator Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Steffen KK (2008) [12]
    Synthetic Rescue
    bait Wang C (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSD1
  • CLA1
  • MCS1
  • SRK1
  • YDR293C
    		•  The BioGRID Database Seperator Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
    Gene Ontology: [View List]
    Dosage Rescue
    hit Reinke A (2004) [27]
    Synthetic Lethality
    hit Alarcon CM (1999) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKB1
  • YGL019W
    		•  The BioGRID Database Seperator Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases
    Gene Ontology: [View List]
    Negative Genetic
    hit Wilmes GM (2008) [6467]
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTR2
  • YGR163W
    		•  The BioGRID Database Seperator Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Dubouloz F (2005) [26]
    hit Zurita-Martinez SA (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPD3
  • FUN32
  • YAL016W
    		•  The BioGRID Database Seperator Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS161
  • FUS7
  • END6
  • SPE161
  • YCR009C
    		•  The BioGRID Database Seperator Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT7
  • YDR342C
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT6
  • YDR343C
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENA1
  • PMR2
  • HOR6
  • YDR040C
    		•  The BioGRID Database Seperator P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENA2
  • YDR039C
    		•  The BioGRID Database Seperator P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENA5
  • YDR038C
    		•  The BioGRID Database Seperator Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCT8
  • YJL008C
    		•  The BioGRID Database Seperator Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO8
  • YDR481C
    		•  The BioGRID Database Seperator Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNQ2
  • YDR011W
    		•  The BioGRID Database Seperator Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LGE1
  • YPL055C
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant forms abnormally large cells
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lambert JP (2009) [269]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG13
  • APG13
  • YPR185W
    		•  The BioGRID Database Seperator Phosphorylated protein that interacts with Vac8p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway and autophagy
    Gene Ontology: [View List]
    Biochemical Activity
    bait Kamada Y (2009) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAL82
  • YNL314W
    		•  The BioGRID Database Seperator Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC24
  • CLS4
  • YAL041W
    		•  The BioGRID Database Seperator Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRO7
  • SOP1
  • SNI1
  • YPR032W
    		•  The BioGRID Database Seperator Putative effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP1
  • VPT1
  • VPS10
  • YBL017C
    		•  The BioGRID Database Seperator Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYO2
  • CDC66
  • YOR326W
    		•  The BioGRID Database Seperator One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC61
  • YLR378C
    		•  The BioGRID Database Seperator Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAS1
  • GGP1
  • CWH52
  • YMR307W
    		•  The BioGRID Database Seperator Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHO1
  • YPR165W
    		•  The BioGRID Database Seperator GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAT1
  • MEP80
  • NIL1
  • YFL021W
    		•  The BioGRID Database Seperator Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GZF3
  • DEH1
  • NIL2
  • YJL110C
    		•  The BioGRID Database Seperator GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMA1
  • YGL008C
    		•  The BioGRID Database Seperator Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAS5
  • YOL030W
    		•  The BioGRID Database Seperator 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTR1
  • YPR124W
    		•  The BioGRID Database Seperator High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT2
  • YMR011W
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSO2
  • YMR183C
    		•  The BioGRID Database Seperator Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSL5
  • YLR116W
    		•  The BioGRID Database Seperator Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
    Gene Ontology: [View List]
    Two-hybrid
    bait Fromont-Racine M (1997) [167]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAL81
  • UGA35
  • YIR023W
    		•  The BioGRID Database Seperator Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRP1
  • KAP60
  • SCM1
  • YNL189W
    		•  The BioGRID Database Seperator Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
    Gene Ontology: [View List]
    Co-localization
    hit Li H (2006) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS54
  • CGP1
  • TCS3
  • LUV1
  • YDR027C
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRM1
  • KAP124
  • XPO1
  • YGR218W
    		•  The BioGRID Database Seperator Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
    Gene Ontology: [View List]
    Co-localization
    hit Li H (2006) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MTF1
  • YMR228W
    		•  The BioGRID Database Seperator Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCD14
  • TRM61
  • YJL125C
    		•  The BioGRID Database Seperator Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAL80
  • UGA43
  • YKR034W
    		•  The BioGRID Database Seperator Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKS1
  • CWH53
  • GSC1
  • PBR1
  • YLR342W
    		•  The BioGRID Database Seperator Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE2
  • YFL026W
    		•  The BioGRID Database Seperator Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM33
  • YBR078W
    		•  The BioGRID Database Seperator GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLG1
  • HCS77
  • WSC1
  • YOR008C
    		•  The BioGRID Database Seperator Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT3
  • YDR345C
    		•  The BioGRID Database Seperator Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT4
  • RAG1
  • LGT1
  • YHR092C
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTR2
  • YKR093W
    		•  The BioGRID Database Seperator Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GYP5
  • YPL249C
    		•  The BioGRID Database Seperator GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPO3
  • YPR156C
    		•  The BioGRID Database Seperator Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOR1
  • YRS1
  • YGR281W
    		•  The BioGRID Database Seperator Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSC2
  • FKS2
  • YGR032W
    		•  The BioGRID Database Seperator Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNF2
  • YDR093W
    		•  The BioGRID Database Seperator Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT5
  • YHR096C
    		•  The BioGRID Database Seperator Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UTR2
  • CRH2
  • YEL040W
    		•  The BioGRID Database Seperator Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHS1
  • USA4
  • YNL192W
    		•  The BioGRID Database Seperator Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAS3
  • YMR215W
    		•  The BioGRID Database Seperator Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NCE102
  • NCE2
  • YPR149W
    		•  The BioGRID Database Seperator Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRH1
  • YDR033W
    		•  The BioGRID Database Seperator Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUR7
  • YML052W
    		•  The BioGRID Database Seperator Putative integral membrane protein; component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRE1
  • YLR214W
    		•  The BioGRID Database Seperator Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT1
  • HOR4
  • YHR094C
    		•  The BioGRID Database Seperator Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYG1
  • YIL047C
    		•  The BioGRID Database Seperator Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC1
  • RSD1
  • YKL212W
    		•  The BioGRID Database Seperator Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAT1
  • MRT1
  • YCR077C
    		•  The BioGRID Database Seperator Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOT1
  • PCH1
  • YDR440W
    		•  The BioGRID Database Seperator Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSL1
  • NIK1
  • YKL101W
    		•  The BioGRID Database Seperator Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
    Gene Ontology: [View List]
    Positive Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ANP1
  • MNN8
  • GEM3
  • YEL036C
    		•  The BioGRID Database Seperator Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTE1
  • MSI2
  • YAL024C
    		•  The BioGRID Database Seperator Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUS1
  • YBR111W-A
    		•  The BioGRID Database Seperator Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN4
  • YKL062W
    		•  The BioGRID Database Seperator Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Hosiner D (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRA1
  • YHR099W
    		•  The BioGRID Database Seperator Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Hoke SM (2008) [111]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHB1
  • YGR132C
    		•  The BioGRID Database Seperator Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Wang X (2008) [24]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN2
  • YMR037C
    		•  The BioGRID Database Seperator Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Hosiner D (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Wang C (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PET9
  • AAC2
  • ANC2
  • YBL030C
    		•  The BioGRID Database Seperator Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Wang X (2008) [24]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM8
  • YBR076W
    		•  The BioGRID Database Seperator Non-essential protein of unknown function
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EST2
  • YLR318W
    		•  The BioGRID Database Seperator Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
    Gene Ontology: [View List]
    Dosage Rescue
    bait Chen XF (2009) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCZ1
  • CVT16
  • YBR131W
    		•  The BioGRID Database Seperator Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAM37
  • MAS37
  • TOM37
  • PET3027
  • YMR060C
    		•  The BioGRID Database Seperator Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSH2
  • PMS5
  • YOL090W
    		•  The BioGRID Database Seperator Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • VAC5
  • AGS3
  • TUP7
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE5
  • YNR051C
    		•  The BioGRID Database Seperator Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDJ1
  • MAS5
  • HSP40
  • YNL064C
    		•  The BioGRID Database Seperator Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JNM1
  • INS1
  • PAC3
  • YMR294W
    		•  The BioGRID Database Seperator Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LEA1
  • YPL213W
    		•  The BioGRID Database Seperator Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PET20
  • YPL159C
    		•  The BioGRID Database Seperator Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP5
  • RAT8
  • YOR046C
    		•  The BioGRID Database Seperator Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Scarcelli JJ (2008) [96]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADO1
  • YJR105W
    		•  The BioGRID Database Seperator Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIA1
  • EFL1
  • YNL163C
    		•  The BioGRID Database Seperator Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM5
  • PFD5
  • YML094W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP4
  • TOT7
  • HAP1
  • YPL101W
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT7
  • AST4
  • VAM4
  • YML001W
    		•  The BioGRID Database Seperator GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD6
  • AIP3
  • YLR319C
    		•  The BioGRID Database Seperator Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDL180W
  • YDL180W
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RXT3
  • YDL076C
    		•  The BioGRID Database Seperator Subunit of the RPD3L complex; involved in histone deacetylation
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AGP1
  • YCC5
  • YCL025C
    		•  The BioGRID Database Seperator Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NGR1
  • RBP1
  • YBR212W
    		•  The BioGRID Database Seperator RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPS1
  • FDP1
  • GGS1
  • CIF1
  • YBR126C
    		•  The BioGRID Database Seperator Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAA1
  • YDR071C
    		•  The BioGRID Database Seperator Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ITC1
  • YGL133W
    		•  The BioGRID Database Seperator Component of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEH1
  • GSE2
  • EGO1
  • YKR007W
    		•  The BioGRID Database Seperator Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LST4
  • YKL176C
    		•  The BioGRID Database Seperator Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASK10
  • YGR097W
    		•  The BioGRID Database Seperator Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIB2
  • YGL023C
    		•  The BioGRID Database Seperator Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YSA1
  • RMA2
  • YBR111C
    		•  The BioGRID Database Seperator Nudix hydrolase family member with ADP-ribose pyrophosphatase activity
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC3
  • LEP1
  • YDR159W
    		•  The BioGRID Database Seperator Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RNR1
  • CRT7
  • RIR1
  • SDS12
  • YER070W
    		•  The BioGRID Database Seperator Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOM3
  • SIL4
  • BOR1
  • YER052C
    		•  The BioGRID Database Seperator Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOM2
  • YDR158W
    		•  The BioGRID Database Seperator Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LST7
  • YGR057C
    		•  The BioGRID Database Seperator Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SER2
  • YGR208W
    		•  The BioGRID Database Seperator Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AAT2
  • ASP5
  • YLR027C
    		•  The BioGRID Database Seperator Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRP20
  • YDR405W
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the large subunit
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SER1
  • ADE9
  • YOR184W
    		•  The BioGRID Database Seperator 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LIP2
  • YLR239C
    		•  The BioGRID Database Seperator Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG3
  • SYR1
  • PSO6
  • YLR056W
    		•  The BioGRID Database Seperator C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUP1
  • YGR055W
    		•  The BioGRID Database Seperator High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARG82
  • ARGR3
  • IPK2
  • YDR173C
    		•  The BioGRID Database Seperator Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS27B
  • YHR021C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL12B
  • YDR418W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPP2B
  • RPL45
  • YPA1
  • YDR382W
    		•  The BioGRID Database Seperator Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNA2
  • WEB2
  • YHR164C
    		•  The BioGRID Database Seperator Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Fiorentino DF (1997) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHR020W
  • YHR020W
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS20
  • URP2
  • YHL015W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPH1
  • YPR160W
    		•  The BioGRID Database Seperator Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF7
  • VPS32
  • DID1
  • RNS4
  • YLR025W
    		•  The BioGRID Database Seperator One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MFT1
  • MFT52
  • YML062C
    		•  The BioGRID Database Seperator Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NBP2
  • YDR162C
    		•  The BioGRID Database Seperator Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMO1
  • HSM2
  • YDR174W
    		•  The BioGRID Database Seperator Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Berger AB (2007) [32]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Aronova S (2007) [124]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMR1
  • BSD1
  • SSC1
  • LDB1
  • YGL167C
    		•  The BioGRID Database Seperator High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Devasahayam G (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP5
  • VPT11
  • END1
  • VPL9
  • YMR231W
    		•  The BioGRID Database Seperator Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Zurita-Martinez SA (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM15
  • TAK1
  • YFL033C
    		•  The BioGRID Database Seperator Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Wei M (2008) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait McClellan AJ (2007) [1419]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP22
  • YER013W
    		•  The BioGRID Database Seperator DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
    Gene Ontology: [View List]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KRS1
  • GCD5
  • YDR037W
    		•  The BioGRID Database Seperator Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
    Gene Ontology: [View List]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait McClellan AJ (2007) [1419]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP3
  • VPS18
  • VAM8
  • VPT18
  • YLR148W
    		•  The BioGRID Database Seperator Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Zurita-Martinez SA (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS16
  • VAM9
  • SVL6
  • VPT16
  • YPL045W
    		•  The BioGRID Database Seperator Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Zurita-Martinez SA (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HFI1
  • GAN1
  • SRM12
  • SUP110
  • YPL254W
    		•  The BioGRID Database Seperator Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF14
  • SWP29
  • TFG3
  • ANC1
  • YPL129W
    		•  The BioGRID Database Seperator Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000) [29]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI6
  • PSL8
  • SDS11
  • YLR182W
    		•  The BioGRID Database Seperator