The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for TOR1 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

TOR1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: DRR1, YJR066W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis|Tor1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 22 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with TOR1

TOR1 was identified with 86 protein interactions and 71 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 KOG1
  • LAS24
  • YHR186C
    		•  The BioGRID Database Seperator Kog1p|Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Wedaman KP (2003)
    bait/hit Loewith R (2002)
    hit Reinke A (2006)
    hit Nakashima A (2008)
    Affinity Capture-MS
    bait/hit Reinke A (2004)
    Co-purification
    hit Adami A (2007)
    hit Wanke V (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LST8
  • YNL006W
    		•  The BioGRID Database Seperator Lst8p|Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Chen EJ (2003)
    bait Wedaman KP (2003)
    bait/hit Loewith R (2002)
    Affinity Capture-MS
    bait/hit Reinke A (2004)
    Co-purification
    hit Wanke V (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TCO89
  • YPL180W
    		•  The BioGRID Database Seperator Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin|Tco89p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Reinke A (2004)
    Affinity Capture-MS
    hit Reinke A (2004)
    Co-purification
    hit Wanke V (2008)
    Synthetic Lethality
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLT2
  • BYC2
  • MPK1
  • SLK2
  • YHR030C
    		•  The BioGRID Database Seperator Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway|Slt2p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    Synthetic Lethality
    bait Torres J (2002)
    hit Aronova S (2007)
    Dosage Rescue
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLM4
  • NIR1
  • EGO3
  • GSE1
  • YBR077C
    		•  The BioGRID Database Seperator Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4|Slm4p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Huang J (2004)
    Synthetic Growth Defect
    bait Huang J (2004)
    hit Zurita-Martinez SA (2007)
    Phenotypic Enhancement
    bait Huang J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR2
  • DRR2
  • YKL203C
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis|Tor2p; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Wedaman KP (2003)
    Phenotypic Enhancement
    hit Helliwell SB (1994)
    Dosage Rescue
    hit Reinke A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLN3
  • YER040W
    		•  The BioGRID Database Seperator Gln3p|Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Carvalho J (2003)
    hit Bertram PG (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIK1
  • ARM5
  • PAC14
  • YCL029C
    		•  The BioGRID Database Seperator Bik1p|Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Choi JH (2000)
    Affinity Capture-Western
    bait/hit Choi JH (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCH9
  • KOM1
  • YHR205W
    		•  The BioGRID Database Seperator Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB|Sch9p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Urban J (2007)
    hit Wanke V (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRV2
  • CAP
  • YNL138W
    		•  The BioGRID Database Seperator CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis|Srv2p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    Synthetic Lethality
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA2
  • END4
  • MOP2
  • YNL243W
    		•  The BioGRID Database Seperator Sla2p|Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    Synthetic Lethality
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPK1
  • SLI2
  • YKL126W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK|Ypk1p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    Synthetic Growth Defect
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM2
  • IPL2
  • SUP9
  • TSL1
  • YER155C
    		•  The BioGRID Database Seperator Bem2p|Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    Synthetic Lethality
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC6
  • ABP67
  • YDR129C
    		•  The BioGRID Database Seperator Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton|Sac6p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    Synthetic Lethality
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHE4
  • DIM1
  • YOR035C
    		•  The BioGRID Database Seperator Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization|She4p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    Synthetic Growth Defect
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URE2
  • YNL229C
    		•  The BioGRID Database Seperator Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion|Ure2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000)
    Phenotypic Suppression
    hit Chan TF (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTR2
  • YGR163W
    		•  The BioGRID Database Seperator Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD|Gtr2p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Dubouloz F (2005)
    hit Zurita-Martinez SA (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSD1
  • CLA1
  • MCS1
  • RLT1
  • YDR293C
    		•  The BioGRID Database Seperator Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence|Ssd1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Reinke A (2004)
    Synthetic Lethality
    hit Alarcon CM (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTG2
  • YGL252C
    		•  The BioGRID Database Seperator Rtg2p|Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Chan TF (2000)
    hit Jin R (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC8
  • YEB3
  • YEL013W
    		•  The BioGRID Database Seperator Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions|Vac8p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    Synthetic Growth Defect
    hit Zurita-Martinez SA (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENA5
  • YDR038C
    		•  The BioGRID Database Seperator Ena5p|Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENA2
  • YDR039C
    		•  The BioGRID Database Seperator Ena2p|P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCT8
  • YJL008C
    		•  The BioGRID Database Seperator Cct8p|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPD3
  • FUN32
  • YAL016W
    		•  The BioGRID Database Seperator Regulatory subunit A of the heterotrimeric protein phosphatase 2A, which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and for transcription by RNA polymerase III|Tpd3p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENA1
  • HOR6
  • PMR2
  • YDR040C
    		•  The BioGRID Database Seperator Ena1p|P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS161
  • END6
  • FUS7
  • SPE161
  • YCR009C
    		•  The BioGRID Database Seperator Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress|Rvs161p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNQ2
  • YDR011W
    		•  The BioGRID Database Seperator Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species|Snq2p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOR1
  • YRS1
  • YGR281W
    		•  The BioGRID Database Seperator Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin|Yor1p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKS1
  • CND1
  • CWH53
  • ETG1
  • YLR342W
    		•  The BioGRID Database Seperator Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling|Fks1p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds|Ubp6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT7
  • YDR342C
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels|Hxt7p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT6
  • YDR343C
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3|Hxt6p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    hit Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAT1
  • MEP80
  • NIL1
  • YFL021W
    		•  The BioGRID Database Seperator Gat1p|Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Bertram PG (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DAL80
  • UGA43
  • YKR034W
    		•  The BioGRID Database Seperator Dal80p|Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid