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BioGRID | Network Layout for CPR7 for Saccharomyces cerevisiae
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CPR7

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YJR032W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Cpr7p|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CPR7

CPR7 was identified with 33 protein interactions and 63 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Mayr C (2000)
    Affinity Capture-Western
    bait Liu XD (1999)
    bait/hit Marsh JA (1998)
    bait Duina AA (1996)
    hit Abbas-Terki T (2001)
    Two-hybrid
    bait Zhao R (2005)
    Affinity Capture-MS
    bait Zhao R (2005)
    Synthetic Lethality
    bait Zhao R (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CNS1
  • YBR155W
    		•  The BioGRID Database Seperator Cns1p|TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Tesic M (2003)
    hit Marsh JA (1998)
    hit Dolinski KJ (1998)
    Co-fractionation
    hit Tesic M (2003)
    Dosage Rescue
    bait Tesic M (2003)
    hit Dolinski KJ (1998)
    hit Marsh JA (1998)
    Synthetic Lethality
    hit Tesic M (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Dolinski KJ (1998)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Phenotypic Enhancement
    bait Bali M (2003)
    bait Duina AA (1998)
    Synthetic Growth Defect
    hit Duina AA (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP104
  • YLL026W
    		•  The BioGRID Database Seperator Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation|Hsp104p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Abbas-Terki T (2001)
    hit Mackay RG (2008)
    Reconstituted Complex
    bait Abbas-Terki T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Jones G (2004)
    hit Mackay RG (2008)
    Phenotypic Enhancement
    bait Jones G (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • MOF6
  • REC3
  • SDI2
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing|Rpd3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Duina AA (1996)
    Reconstituted Complex
    hit Duina AA (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THP2
  • YHR167W
    		•  The BioGRID Database Seperator Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance|Thp2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STI1
  • YOR027W
    		•  The BioGRID Database Seperator Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Duina AA (1996)
    Synthetic Lethality
    bait Flom G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GYP1
  • YOR29-21
  • YOR070C
    		•  The BioGRID Database Seperator Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion|Gyp1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Lafourcade C (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS161
  • END6
  • FUS7
  • SPE161
  • YCR009C
    		•  The BioGRID Database Seperator Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress|Rvs161p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIN2
  • YLR096W
    		•  The BioGRID Database Seperator Kin2p|Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA3
  • YG106
  • YBL075C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Ssa3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Marsh JA (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC37
  • SMO1
  • YDR168W
    		•  The BioGRID Database Seperator Cdc37p|Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Abbas-Terki T (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRA1
  • SHE11
  • YDR381W
    		•  The BioGRID Database Seperator Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function|Yra1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MFT1
  • MFT52
  • YML062C
    		•  The BioGRID Database Seperator Mft1p|Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM4
  • ROM7
  • YPL161C
    		•  The BioGRID Database Seperator Bem4p|Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HPR1
  • TRF1
  • YDR138W
    		•  The BioGRID Database Seperator Hpr1p|Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GVP36
  • YIL041W
    		•  The BioGRID Database Seperator Golgi vesicle protein of unknown function; localizes to both early and late Golgi vesicles; may interact with ribosomes, based on co-purification experiments|Gvp36p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOT3
  • YIL038C
    		•  The BioGRID Database Seperator Not3p|Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TDH1
  • GLD3
  • YJL052W
    		•  The BioGRID Database Seperator Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall|Tdh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC3
  • YLR314C
    		•  The BioGRID Database Seperator Cdc3p|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin|Htz1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM1
  • SPB8
  • YJL124C
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs|Lsm1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAH1
  • YCR060W
    		•  The BioGRID Database Seperator HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs|Tah1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRA2
  • CCS1
  • GLC4
  • YOL081W
    		•  The BioGRID Database Seperator GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin|Ira2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHP1
  • YDR451C
    		•  The BioGRID Database Seperator One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval|Yhp1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APQ12
  • YIL040W
    		•  The BioGRID Database Seperator Apq12p|Protein involved in nucleocytoplasmic transport of mRNA; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCK1
  • YPK1
  • YNL307C
    		•  The BioGRID Database Seperator Mck1p|Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCR2
  • YNL199C
    		•  The BioGRID Database Seperator Gcr2p|Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP12
  • YJL197W
    		•  The BioGRID Database Seperator Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins|Ubp12p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRC1
  • YML033W
  • HEH1
  • YML034W
    		•  The BioGRID Database Seperator Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence|Src1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS8
  • FUN15
  • VPT8
  • YAL002W
    		•  The BioGRID Database Seperator Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif|Vps8p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA34
  • YJL148W
    		•  The BioGRID Database Seperator RNA polymerase I subunit A34.5|Rpa34p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MON2
  • YSL2
  • YNL297C
    		•  The BioGRID Database Seperator Mon2p|Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DEG1
  • PUS3
  • YFL001W
    		•  The BioGRID Database Seperator Deg1p|Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHD1
  • YER164W
    		•  The BioGRID Database Seperator Chd1p|Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG2
  • EAF4
  • NBN1
  • YHR090C
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1|Yng2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT109
  • KIM2
  • REM50
  • YLL002W
    		•  The BioGRID Database Seperator Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition|Rtt109p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Fillingham J (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIK1
  • YMR198W
    		•  The BioGRID Database Seperator Cik1p|Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p; protein coding
    Gene Ontology: [View List]