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BioGRID | Network Layout for OST1 for Saccharomyces cerevisiae
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OST1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: NLT1, YJL002C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins|Ost1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with OST1

OST1 was identified with 55 protein interactions and 23 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 WBP1
  • YEL002C
    		•  The BioGRID Database Seperator Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum|Wbp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    Affinity Capture-Western
    bait/hit Yan A (2003)
    bait Li G (2003)
    Two-hybrid
    bait Scheper W (2003)
    bait Yan A (2005)
    bait/hit Yan A (2005)
    Co-purification
    hit Pathak R (1997)
    hit Spirig U (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STT3
  • YGL022W
    		•  The BioGRID Database Seperator Stt3p|Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Spirig U (1997)
    hit Gavin AC (2006)
    bait Collins SR (2007)
    Affinity Capture-Western
    bait Karaoglu D (1997)
    bait/hit Yan A (2003)
    Co-purification
    bait/hit Spirig U (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST3
  • YOR085W
    		•  The BioGRID Database Seperator Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins|Ost3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Karaoglu D (1997)
    bait/hit Yan A (2003)
    Two-hybrid
    bait/hit Yan A (2005)
    Co-purification
    hit Pathak R (1997)
    bait Schwarz M (2005)
    hit Spirig U (2005)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST6
  • YML019W
    		•  The BioGRID Database Seperator Ost6p|Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    Affinity Capture-Western
    bait/hit Yan A (2003)
    bait Yan A (2005)
    Two-hybrid
    bait/hit Yan A (2005)
    Co-purification
    bait Schwarz M (2005)
    hit Spirig U (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWP1
  • YMR149W
    		•  The BioGRID Database Seperator Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum|Swp1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    Affinity Capture-Western
    bait/hit Yan A (2003)
    Co-purification
    hit Pathak R (1997)
    hit Spirig U (2005)
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST5
  • YGL226C-A
    		•  The BioGRID Database Seperator Ost5p|Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Yan A (2003)
    Dosage Rescue
    hit Reiss G (1997)
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST2
  • YOR103C
    		•  The BioGRID Database Seperator Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins|Ost2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Yan A (2003)
    Co-purification
    hit Pathak R (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERO1
  • YML130C
    		•  The BioGRID Database Seperator Ero1p|Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF34
  • YMR146C
    		•  The BioGRID Database Seperator Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation|Tif34p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBH1
  • SEB1
  • YER087C-A
  • YER087C-B
    		•  The BioGRID Database Seperator Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p|Sbh1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Yan A (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBH2
  • SEB2
  • YER019C-A
    		•  The BioGRID Database Seperator Sbh2p|Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Yan A (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST4
  • YDL232W
    		•  The BioGRID Database Seperator Ost4p|Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Yan A (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSS1
  • YDR086C
    		•  The BioGRID Database Seperator Sss1p|Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Chavan M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PKC1
  • CLY15
  • HPO2
  • STT1
  • YBL105C
    		•  The BioGRID Database Seperator Pkc1p|Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Park H (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC61
  • YLR378C
    		•  The BioGRID Database Seperator Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER|Sec61p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Chavan M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST1
  • NLT1
  • YJL002C
    		•  The BioGRID Database Seperator Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins|Ost1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Yan A (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UIP3
  • YAR027W
    		•  The BioGRID Database Seperator Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family|Uip3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEH1
  • YGL100W
    		•  The BioGRID Database Seperator Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p|Seh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC13
  • ANU3
  • YLR208W
    		•  The BioGRID Database Seperator Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles|Sec13p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJR015W
  • YJR015W
    		•  The BioGRID Database Seperator Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene|Yjr015wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPI2
  • GCR4
  • YPL076W
    		•  The BioGRID Database Seperator Gpi2p|Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COS8
  • YHL048W
    		•  The BioGRID Database Seperator Cos8p|Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSC13
  • YDL015C
    		•  The BioGRID Database Seperator Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p|Tsc13p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAN1
  • YEL063C
    		•  The BioGRID Database Seperator Can1p|Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RHK1
  • ALG3
  • YBL082C
    		•  The BioGRID Database Seperator Alg3p|Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OPI3
  • PEM2
  • YJR073C
    		•  The BioGRID Database Seperator Opi3p|Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Ire1p|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LAS21
  • GPI7
  • YJL062W
    		•  The BioGRID Database Seperator Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity|Las21p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIC1
  • YLR039C
    		•  The BioGRID Database Seperator Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GYP1
  • YOR29-21
  • YOR070C
    		•  The BioGRID Database Seperator Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion|Gyp1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RER1
  • YCL001W
    		•  The BioGRID Database Seperator Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER|Rer1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ROT2
  • GLS2
  • YBR229C
    		•  The BioGRID Database Seperator Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations|Rot2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait/hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCJ1
  • YMR214W
    		•  The BioGRID Database Seperator One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins|Scj1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE24
  • AFC1
  • PIO2
  • YJR117W
    		•  The BioGRID Database Seperator Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans|Ste24p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG8
  • DOR1
  • YML071C
    		•  The BioGRID Database Seperator Cog8p|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG8
  • YOR29-18
  • YOR067C
    		•  The BioGRID Database Seperator Alg8p|Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG6
  • YOR002W
    		•  The BioGRID Database Seperator Alg6p|Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG5
  • YPL227C
    		•  The BioGRID Database Seperator Alg5p|UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum; protei