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BioGRID | Network Layout for BBC1 for Saccharomyces cerevisiae
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BBC1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: MTI1, YJL021C, YJL020C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Bbc1p|Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with BBC1

BBC1 was identified with 49 protein interactions and 29 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 MYO5
  • YMR109W
    		•  The BioGRID Database Seperator Myo5p|One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Mochida J (2002)
    Reconstituted Complex
    bait Mochida J (2002)
    Two-hybrid
    hit Mochida J (2002)
    bait/hit Tong AH (2002)
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LAS17
  • BEE1
  • YOR181W
    		•  The BioGRID Database Seperator Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)|Las17p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Rodal AA (2003)
    Affinity Capture-Western
    bait Tong AH (2002)
    Protein-peptide
    bait Tong AH (2002)
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYO3
  • YKL129C
    		•  The BioGRID Database Seperator Myo3p|One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Mochida J (2002)
    Two-hybrid
    bait/hit Mochida J (2002)
    bait Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIR003W
  • AIM21
    		•  The BioGRID Database Seperator Aim21p|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein colocalizes with Sac1p to the actin cytoskeleton; interacts with the SH3 domain of Abp1p; null mutant displays increased rate of mitochondrial...
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BBC1
  • MTI1
  • YJL021C
  • YJL020C
    		•  The BioGRID Database Seperator Bbc1p|Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2006)
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA1
  • YBL007C
    		•  The BioGRID Database Seperator Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains|Sla1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001)
    hit Mochida J (2002)
    Phenotypic Enhancement
    bait Rodal AA (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VRP1
  • END5
  • MDP2
  • YLR337W
  • YLR337C
    		•  The BioGRID Database Seperator Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)|Vrp1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    Synthetic Rescue
    bait Mochida J (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS161
  • END6
  • FUS7
  • SPE161
  • YCR009C
    		•  The BioGRID Database Seperator Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress|Rvs161p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Friesen H (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVS167
  • YDR388W
    		•  The BioGRID Database Seperator Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin|Rvs167p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Friesen H (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC6
  • ABP67
  • YDR129C
    		•  The BioGRID Database Seperator Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton|Sac6p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Tong AH (2001)
    hit Mochida J (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAC10
  • GIM2
  • PFD3
  • RKS2
  • YGR078C
    		•  The BioGRID Database Seperator Pac10p|Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001)
    bait/hit Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM3
  • PFD4
  • YNL153C
    		•  The BioGRID Database Seperator Gim3p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001)
    bait/hit Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM5
  • PFD5
  • YML094W
    		•  The BioGRID Database Seperator Gim5p|Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Tong AH (2001)
    bait/hit Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO4
  • YFR034C
    		•  The BioGRID Database Seperator Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability|Pho4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Graumann J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAN3
  • ECM35
  • YKL025C
    		•  The BioGRID Database Seperator Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes|Pan3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCL9
  • YDL179W
    		•  The BioGRID Database Seperator Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p|Pcl9p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC14
  • YLR386W
    		•  The BioGRID Database Seperator Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p|Vac14p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB2
  • YBL002W
    		•  The BioGRID Database Seperator Htb2p|One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC40
  • YBR234C
    		•  The BioGRID Database Seperator Arc40p|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MID2
  • KAI1
  • YLR332W
    		•  The BioGRID Database Seperator Mid2p|O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADH7
  • ADHVII
  • YCR105W
    		•  The BioGRID Database Seperator Adh7p|NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC15
  • YIL062C
    		•  The BioGRID Database Seperator Arc15p|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK1
  • PKA1
  • SRA3
  • YJL164C
    		•  The BioGRID Database Seperator Tpk1p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • AGS3
  • TUP7
  • VAC5
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance|Pho80p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • STK2
  • YJR059W
    		•  The BioGRID Database Seperator Ptk2p|Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRN1
  • YLR429W
    		•  The BioGRID Database Seperator Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity|Crn1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDL129W
  • YDL129W
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene|Ydl129wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKT5
  • CAL2
  • CHS4
  • CSD4
  • YBL061C
    		•  The BioGRID Database Seperator Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation|Skt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APP1
  • YNL094W
    		•  The BioGRID Database Seperator App1p|Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM8
  • YJR022W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA|Lsm8p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Fromont-Racine M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT5
  • YML010W
    		•  The BioGRID Database Seperator Protein that forms a complex with Spt4p and mediates both activation and inhibition of transcription elongation; Spt4p-Spt5p complex also plays a role in pre-mRNA processing|Spt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lindstrom DL (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSY2
  • YLR258W
    		•  The BioGRID Database Seperator Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase|Gsy2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPR1
  • CPH1
  • CYP1
  • YDR155C
    		•  The BioGRID Database Seperator Cpr1p|Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRT1
  • HRT2
  • RBX1
  • ROC1
  • YOL133W
    		•  The BioGRID Database Seperator Hrt1p|RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIR1
  • PIP1
  • YER032W
    		•  The BioGRID Database Seperator Fir1p|Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PKC1
  • CLY15
  • HPO2
  • STT1
  • YBL105C
    		•  The BioGRID Database Seperator Pkc1p|Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC); protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STC2
  • TGL5
  • YOR081C
    		•  The BioGRID Database Seperator Tgl5p|Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GDB1
  • YPR184W
    		•  The BioGRID Database Seperator Gdb1p|Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NFI1
  • SIZ2
  • YOR156C
    		•  The BioGRID Database Seperator Nfi1p|SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOF1
  • CYK2
  • YMR032W
    		•  The BioGRID Database Seperator Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p|Hof1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAP1
  • YNL023C
    		•  The BioGRID Database Seperator Fap1p|Protein that binds to Fpr1p (FKBP12), conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; has similarity to putative transcription factors, including D. melanogaster shuttle craft and human NFX1; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Tong AH (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator