| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
 |
| TIF2 |
YJL138C |
 |
Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
|
|
 |
 |
 |
| RBL2 |
YOR265W |
 |
Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A
|
|
 |
 |
 |
| NAB2 |
YGL122C |
 |
Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
|
|
 |
 |
 |
| JSN1 |
PUF1YJR091C |
 |
Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
|
|
 |
 |
 |
| IRC3 |
YDR332W |
 |
hypothetical protein; null mutant displays increased levels of spontaneous Rad52 foci
|
|
 |
 |
 |
| RCO1 |
YMR075W |
 |
Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
|
|
 |
 |
 |
| ISW2 |
YOR304W |
 |
Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
|
|
 |
 |
 |
| HSC82 |
HSP90YMR186W |
 |
Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
|
|
 |
 |
 |
| HSP82 |
HSP90YPL240C |
 |
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
|
|
 |
 |
 |
| MTW1 |
NSL2DSN3YAL034W-A |
 |
Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
|
|
 |
 |
 |