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BioGRID | Network Layout for GCN5 for Saccharomyces cerevisiae
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GCN5

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SWI9, ADA4, YGR252W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 24 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with GCN5

GCN5 was identified with 250 protein interactions and 368 genetic interactions
Displaying:
<
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 ADA2
  • SWI8
  • YDR448W
    		•  The BioGRID Database Seperator Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    bait Rodriguez-Navarro S (2004) [74]
    bait Lee KK (2005) [54]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    bait Koehler A (2008) [42]
    bait Lee KK (2009) [47]
    Two-hybrid
    hit Uetz P (2000) [875]
    bait Marcus GA (1994) [2]
    hit Wang L (1997) [7]
    Affinity Capture-Western
    bait Sterner DE (2002) [18]
    bait/hit Candau R (1996) [5]
    bait/hit Candau R (1996) [5]
    bait/hit Candau R (1997) [2]
    bait Horiuchi J (1995) [4]
    bait Marcus GA (1994) [2]
    bait Henry KW (2003) [12]
    bait Qiu H (2005) [17]
    hit Hoke SM (2008) [3]
    hit Li S (2009) [17]
    Reconstituted Complex
    bait Candau R (1996) [5]
    bait Eberharter A (1999) [13]
    bait Balasubramanian R (2002) [3]
    Co-purification
    bait Boyer LA (2002) [5]
    bait Horiuchi J (1997) [7]
    bait Henry KW (2003) [12]
    Synthetic Rescue
    hit Chiu YH (2003) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT7
  • GIT2
  • YBR081C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    bait Wu PY (2004) [14]
    hit Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Wu PY (2002) [17]
    bait Qiu H (2005) [17]
    hit Hoke SM (2007) [6]
    bait Mischerikow N (2009) [32]
    hit Li S (2009) [17]
    Co-purification
    bait Pray-Grant MG (2002) [35]
    Phenotypic Enhancement
    bait Wu PY (2002) [17]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP8
  • YMR223W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    bait Sanders SL (2002) [483]
    bait Lee KK (2005) [54]
    bait Ingvarsdottir K (2005) [143]
    bait Krogan NJ (2006) [7079]
    hit Graumann J (2004) [478]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Daniel JA (2004) [14]
    bait Henry KW (2003) [12]
    hit Powell DW (2004) [24]
    Co-localization
    bait Wyce A (2007) [22]
    Synthetic Growth Defect
    bait Henry KW (2003) [12]
    bait Wyce A (2007) [22]
    hit Lee KK (2009) [47]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF10
  • TAF25
  • TAF23
  • YDR167W
    		•  The BioGRID Database Seperator Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Sanders SL (2002) [483]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Sanders SL (2000) [94]
    bait Kirschner DB (2002) [15]
    bait Kirchner J (2001) [18]
    hit Powell DW (2004) [24]
    hit Li S (2009) [17]
    Co-purification
    bait Pray-Grant MG (2002) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • SIN2
  • BUR5
  • YBR010W
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Ornaghi P (1999) [4]
    Biochemical Activity
    hit Kuo MH (1996) [2]
    hit Syntichaki P (1998) [8]
    hit Clarke AS (1999) [8]
    hit Adkins MW (2007) [5]
    bait Chimenti F (2009) [2]
    bait Li S (2009) [17]
    Affinity Capture-Western
    hit Hassan AH (2007) [20]
    Synthetic Rescue
    hit Perez-Martin J (1998) [4]
    hit Pollard KJ (1997) [9]
    Synthetic Lethality
    hit Zhang W (1998) [4]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF6
  • TAF60
  • YGL112C
    		•  The BioGRID Database Seperator Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Ho Y (2002) [3666]
    bait Rodriguez-Navarro S (2004) [74]
    bait Sanders SL (2002) [483]
    bait Ingvarsdottir K (2005) [143]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Li S (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT2
  • YNL031C
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Ornaghi P (1999) [4]
    Biochemical Activity
    hit Syntichaki P (1998) [8]
    hit Clarke AS (1999) [8]
    hit Adkins MW (2007) [5]
    bait Chimenti F (2009) [2]
    bait Li S (2009) [17]
    Affinity Capture-Western
    hit Hassan AH (2007) [20]
    Synthetic Lethality
    hit Zhang W (1998) [4]
    hit Ruault M (2006) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NGG1
  • ADA3
  • SWI7
  • YDR176W
    		•  The BioGRID Database Seperator Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Horiuchi J (1995) [4]
    hit Li S (2009) [17]
    Reconstituted Complex
    bait Eberharter A (1999) [13]
    bait Balasubramanian R (2002) [3]
    Co-purification
    hit Pollard KJ (1997) [9]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT8
  • YLR055C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Eberharter A (1999) [13]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    hit Collins SR (2007) [9064]
    bait Lee KK (2009) [47]
    Affinity Capture-Western
    hit Li S (2009) [17]
    Phenotypic Enhancement
    hit Sterner DE (1999) [19]
    bait Wu PY (2002) [17]
    Synthetic Lethality
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGF11
  • YPL047W
    		•  The BioGRID Database Seperator Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Powell DW (2004) [24]
    bait Lee KK (2005) [54]
    bait Ingvarsdottir K (2005) [143]
    bait Krogan NJ (2006) [7079]
    hit Graumann J (2004) [478]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Powell DW (2004) [24]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF5
  • TAF90
  • YBR198C
    		•  The BioGRID Database Seperator Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanders SL (2002) [483]
    bait Krogan NJ (2006) [7079]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    Co-purification
    bait Grant PA (1998) [12]
    Affinity Capture-Western
    bait Takahata S (2004) [16]
    hit Li S (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HFI1
  • GAN1
  • SRM12
  • SUP110
  • YPL254W
    		•  The BioGRID Database Seperator Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Sermwittayawong D (2006) [16]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Horiuchi J (1997) [7]
    hit Li S (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Li S (2009) [17]
    Phenotypic Enhancement
    hit Barbaric S (2003) [1]
    hit Sterner DE (1999) [19]
    Synthetic Rescue
    hit Yu Y (2003) [10]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Ornaghi P (1999) [4]
    Biochemical Activity
    hit Kuo MH (1996) [2]
    hit Syntichaki P (1998) [8]
    bait Li S (2009) [17]
    Affinity Capture-Western
    hit Hassan AH (2007) [20]
    Synthetic Rescue
    hit Perez-Martin J (1998) [4]
    hit Pollard KJ (1997) [9]
    Synthetic Lethality
    hit Zhang W (1998) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGF73
  • sca7
  • YGL066W
    		•  The BioGRID Database Seperator 73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanders SL (2002) [483]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    bait Koehler A (2008) [42]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Lee KK (2009) [47]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF9
  • TAF17
  • YMR236W
    		•  The BioGRID Database Seperator Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanders SL (2002) [483]
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    hit Collins SR (2007) [9064]
    Co-purification
    bait Grant PA (1998) [13]
    Synthetic Lethality
    bait Milgrom E (2005) [112]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF12
  • TAF61
  • TAF68
  • YDR145W
    		•  The BioGRID Database Seperator Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanders SL (2002) [483]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Powell DW (2004) [24]
    hit Li S (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRA1
  • YHR099W
    		•  The BioGRID Database Seperator Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Graumann J (2004) [478]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Powell DW (2004) [24]
    bait Qiu H (2005) [17]
    hit Li S (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT20
  • ADA5
  • YOL148C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    hit Graumann J (2004) [478]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Li S (2009) [17]
    Synthetic Lethality
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGF29
  • YCL010C
    		•  The BioGRID Database Seperator SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    bait Sanders SL (2002) [483]
    hit Graumann J (2004) [478]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Li S (2009) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF2
  • YNL030W
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Ornaghi P (1999) [4]
    Biochemical Activity
    hit Syntichaki P (1998) [8]
    bait Li S (2009) [17]
    Affinity Capture-Western
    hit Hassan AH (2007) [20]
    Synthetic Lethality
    hit Zhang W (1998) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AHC1
  • YOR023C
    		•  The BioGRID Database Seperator Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Eberharter A (1999) [13]
    Co-purification
    bait Eberharter A (1999) [13]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF2
  • SWI2
  • GAM1
  • TYE3
  • YOR290C
    		•  The BioGRID Database Seperator Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Boukaba A (2004) [1]
    hit Barbaric S (2007) [3]
    Synthetic Lethality
    bait Sudarsanam P (1999) [1]
    hit Biswas D (2004) [18]
    Synthetic Growth Defect
    bait Hassan AH (2002) [2]
    hit Roberts SM (1997) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Zhang H (2005) [4]
    Biochemical Activity
    hit Keogh MC (2006) [3]
    Synthetic Growth Defect
    hit Santisteban MS (2000) [5]
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRE1
  • ERN1
  • YHR079C
    		•  The BioGRID Database Seperator Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Welihinda AA (1997) [3]
    Reconstituted Complex
    hit Welihinda AA (1997) [3]
    Two-hybrid
    bait Welihinda AA (1997) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • SDI2
  • MOF6
  • REC3
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Sun ZW (1999) [7]
    hit Perez-Martin J (1998) [4]
    bait Lin YY (2008) [2599]
    Phenotypic Enhancement
    hit Burgess SM (1999) [1]
    Synthetic Lethality
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP3
  • TOT3
  • HPA1
  • YPL086C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Petrakis TG (2005) [6]
    hit Verzijlbergen KF (2009) [16]
    Synthetic Lethality
    hit Wittschieben BO (2000) [5]
    Phenotypic Suppression
    hit Petrakis TG (2005) [6]
    Synthetic Growth Defect
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN4
  • GAL22
  • SDI3
  • RYE1
  • YNL236W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    Synthetic Rescue
    hit Yu Y (2000) [6]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    bait Dettmann A (2010) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT15
  • TBP1
  • BTF1
  • YER148W
    		•  The BioGRID Database Seperator TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sanders SL (2002) [483]
    Synthetic Growth Defect
    hit Yu Y (2003) [10]
    Synthetic Lethality
    bait Biswas D (2004) [18]
    Dosage Rescue
    hit Biswas D (2004) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT1
  • LPF4
  • BUR3
  • YPL082C
    		•  The BioGRID Database Seperator Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Arnett DR (2008) [91]
    Affinity Capture-Western
    bait Arnett DR (2008) [91]
    Synthetic Lethality
    hit Biswas D (2006) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA1
  • H2A1
  • SPT11
  • YDR225W
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Syntichaki P (1998) [8]
    Co-purification
    bait Grant PA (1999) [9]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Mitchell L (2008) [313]
    hit Ginsburg DS (2009) [10]
    Synthetic Lethality
    bait/hit Lin YY (2008) [2599]
    Phenotypic Enhancement
    hit Ginsburg DS (2009) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS3
  • YBL052C
    		•  The BioGRID Database Seperator Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Howe L (2002) [5]
    bait/hit Lin YY (2008) [2599]
    Synthetic Lethality
    bait Howe L (2001) [1]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI1
  • GAM3
  • LPA1
  • ADR6
  • YPL016W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    Synthetic Lethality
    hit Pollard KJ (1997) [9]
    Synthetic Growth Defect
    hit Roberts SM (1997) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC4
  • YKR008W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling
    Gene Ontology: [View List]
    Co-crystal Structure
    bait VanDemark AP (2007) [9]
    Synthetic Lethality
    bait Kasten M (2004) [17]
    bait VanDemark AP (2007) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • PAS14
  • HAF3
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
    Gene Ontology: [View List]
    Biochemical Activity
    bait Liu Y (2005) [4]
    Reconstituted Complex
    bait Liu Y (2005) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUS1
  • YBR111W-A
    		•  The BioGRID Database Seperator Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rodriguez-Navarro S (2004) [74]
    Affinity Capture-Western
    bait Pascual-Garcia P (2008) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLP2
  • YIL149C
    		•  The BioGRID Database Seperator Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Luthra R (2007) [4]
    Reconstituted Complex
    hit Luthra R (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AHC2
  • YCR082W
    		•  The BioGRID Database Seperator Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB6
  • MED22
  • YBR253W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLP1
  • MPL1
  • YKR095W
    		•  The BioGRID Database Seperator Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Luthra R (2007) [4]
    Reconstituted Complex
    hit Luthra R (2007) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IKI3
  • TOT1
  • ELP1
  • YLR384C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Wittschieben BO (2000) [5]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN3
  • CPE1
  • SDI1
  • SDS16
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Yu Y (2000) [6]
    Synthetic Lethality
    bait/hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF6
  • YJR082C
    		•  The BioGRID Database Seperator Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD3
  • SAF35
  • CPS30
  • YBR175W
    		•  The BioGRID Database Seperator Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT2
  • EXA1
  • SIN1
  • YER161C
    		•  The BioGRID Database Seperator Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Perez-Martin J (1998) [4]
    hit Pollard KJ (1997) [9]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF1
  • VID21
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Babiarz JE (2006) [2]
    bait Mitchell L (2008) [313]
    Synthetic Growth Defect
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT109
  • KIM2
  • REM50
  • YLL002W
    		•  The BioGRID Database Seperator Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Lin YY (2008) [2599]
    bait Fillingham J (2008) [158]
    Phenotypic Enhancement
    bait Fillingham J (2008) [158]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KTI12
  • TOT4
  • YKL110C
    		•  The BioGRID Database Seperator Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Petrakis TG (2005) [6]
    Phenotypic Suppression
    hit Petrakis TG (2005) [6]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG1
  • YOR29-15
  • YOR064C
    		•  The BioGRID Database Seperator Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Howe L (2002) [5]
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMT1
  • ODP1
  • RMT1
  • HCP1
  • YBR034C
    		•  The BioGRID Database Seperator Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Kuo MH (2009) [7]
    Phenotypic Suppression
    hit Kuo MH (2009) [7]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRB2
  • HRS2
  • MED20
  • YHR041C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHD1
  • YER164W
    		•  The BioGRID Database Seperator Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SILK complexes
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Pray-Grant MG (2005) [16]
    Synthetic Growth Defect
    bait Biswas D (2007) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED1
  • YPR070W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006) [7592]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REG1
  • PZF240
  • HEX2
  • SPP43
  • YDR028C
    		•  The BioGRID Database Seperator Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Liu Y (2005) [4]
    Synthetic Rescue
    hit Liu Y (2005) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB9
  • SHI1
  • SSU73
  • YGL070C
    		•  The BioGRID Database Seperator RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Van Mullem V (2002) [10]
    bait Wery M (2004) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG2
  • EAF4
  • NBN1
  • YHR090C
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Choy JS (2002) [6]
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF5
  • HAF4
  • SWI10
  • TYE4
  • YBR289W
    		•  The BioGRID Database Seperator Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Recht J (1999) [3]
    hit Roberts SM (1997) [23]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT2
  • NOT4
  • SIG1
  • YER068W
    		•  The BioGRID Database Seperator Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Maillet L (2000) [22]
    Synthetic Lethality
    hit Biswas D (2006) [25]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT16
  • CDC68
  • SSF1
  • YGL207W
    		•  The BioGRID Database Seperator Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Formosa T (2002) [16]
    Synthetic Lethality
    bait Biswas D (2005) [18]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSE2
  • MED9
  • YNR010W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LGE1
  • YPL055C
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant forms abnormally large cells
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP6
  • TOT6
  • HAP3
  • YMR312W
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP4
  • TOT7
  • HAP1
  • YPL101W
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD1
  • FUN16
  • CPS50
  • SAF49
  • YAR003W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE2
  • CPS60
  • YLR015W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF7
  • YNL136W
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Lin YY (2008) [2599]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP2
  • TOT2
  • YGR200C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Wittschieben BO (2000) [5]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX8
  • YER116C
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASF1
  • CIA1
  • YJL115W
    		•  The BioGRID Database Seperator Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Adkins MW (2007) [5]
    Phenotypic Enhancement
    bait Fillingham J (2008) [158]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF5
  • YEL018W
    		•  The BioGRID Database Seperator Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Mitchell L (2008) [313]
    bait/hit Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HDA1
  • YNL021W
    		•  The BioGRID Database Seperator Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
    Gene Ontology: [View List]
    Synthetic Rescue
    bait/hit Lin YY (2008) [2599]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACS2
  • YLR153C
    		•  The BioGRID Database Seperator Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Lin YY (2008) [2599]
    Synthetic Growth Defect
    bait Takahashi H (2006) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HDA3
  • PLO1
  • YPR179C
    		•  The BioGRID Database Seperator Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Lin YY (2008) [2599]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSA1
  • TPX1
  • ZRG14
  • YML028W
    		•  The BioGRID Database Seperator Ubiquitous housekeeping thioredoxin peroxidase, reduces reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; mediates redox regulation of the nuclear localization of Yap1p; deletion results in mutator phenotype
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006) [5331]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOH1
  • MED31
  • YGL127C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Lin YY (2008) [2599]
    bait Dettmann A (2010) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EFT1
  • YOR133W
    		•  The BioGRID Database Seperator Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFK2
  • YMR205C
    		•  The BioGRID Database Seperator Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA2
  • H2A2
  • YBL003C
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Syntichaki P (1998) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB1
  • SPT12
  • YDR224C
    		•  The BioGRID Database Seperator One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Syntichaki P (1998) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADE3
  • YGR204W
    		•  The BioGRID Database Seperator Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DST1
  • PPR2
  • YGL043W
    		•  The BioGRID Database Seperator General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wery M (2004) [19]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GFA1
  • YKL104C
    		•  The BioGRID Database Seperator Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HAC1
  • ERN4
  • IRE15
  • YFL031W
    		•  The BioGRID Database Seperator bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Welihinda AA (2000) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL4
  • GAL81
  • YPL248C
    		•  The BioGRID Database Seperator DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
    Gene Ontology: [View List]
    Co-localization
    bait Larschan E (2001) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAP1
  • SNQ3
  • PAR1
  • YML007W
    		•  The BioGRID Database Seperator Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPP2A
  • RPL44
  • RPLA2
  • YOL039W
    		•  The BioGRID Database Seperator Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL16A
  • RPL13
  • YIL133C
    		•  The BioGRID Database Seperator N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENO2
  • YHR174W
    		•  The BioGRID Database Seperator Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF7
  • TAF67
  • YMR227C
    		•  The BioGRID Database Seperator TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN4
  • YKL062W
    		•  The BioGRID Database Seperator Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLC7
  • CID1
  • DIS2
  • YER133W
    		•  The BioGRID Database Seperator Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FBA1
  • LOT1
  • YKL060C
    		•  The BioGRID Database Seperator Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EFT2
  • YDR385W
    		•  The BioGRID Database Seperator Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB2
  • YBL002W
    		•  The BioGRID Database Seperator One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Syntichaki P (1998) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD59
  • YDL059C
    		•  The BioGRID Database Seperator Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADH1
  • ADC1
  • YOL086C
    		•  The BioGRID Database Seperator Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPZ2
  • YDR436W
    		•  The BioGRID Database Seperator Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPP2B
  • RPL45
  • YPA1
  • YDR382W
    		•  The BioGRID Database Seperator Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS25A
  • RPS31A
  • YGR027C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PGK1
  • YCR012W
    		•  The BioGRID Database Seperator 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPG1
  • TIF32
  • YBR079C
    		•  The BioGRID Database Seperator Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADR1
  • YDR216W
    		•  The BioGRID Database Seperator Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Chiang YC (1996) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIP3
  • YPL137C
    		•  The BioGRID Database Seperator Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TADA2L
  • KL04P
  • ADA2A
  • hADA2
    		•  The BioGRID Database Seperator transcriptional adaptor 2 (ADA2, yeast, homolog)-like
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Wang L (1997) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • STK2
  • YJR059W
    		•  The BioGRID Database Seperator Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO80
  • VAC5
  • AGS3
  • TUP7
  • YOL001W
    		•  The BioGRID Database Seperator Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URA7
  • YBL039C
    		•  The BioGRID Database Seperator Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YSH1
  • BRR5
  • YLR277C
    		•  The BioGRID Database Seperator Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPI1
  • YFR003C
    		•  The BioGRID Database Seperator Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHB1
  • YHB4
  • YGR234W
    		•  The BioGRID Database Seperator Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTI6
  • RXT1
  • YPL181W
    		•  The BioGRID Database Seperator Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Papamichos-Chronakis M (2002) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYC8
  • CRT8
  • SSN6
  • YBR112C
    		•  The BioGRID Database Seperator General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Papamichos-Chronakis M (2002) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS29B
  • YDL061C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS25B
  • YLR333C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator