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BioGRID | Network Layout for ERG25 for Saccharomyces cerevisiae
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ERG25

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YGR060W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol|Erg25p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with ERG25

ERG25 was identified with 72 protein interactions and 30 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 ERG28
  • BUD18
  • YER044C
    		•  The BioGRID Database Seperator Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p|Erg28p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Mo C (2002)
    hit Mo C (2005)
    Two-hybrid
    bait/hit Mo C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG5
  • YPL227C
    		•  The BioGRID Database Seperator Alg5p|UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO88
  • YBR106W
    		•  The BioGRID Database Seperator Pho88p|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO86
  • YJL117W
    		•  The BioGRID Database Seperator Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles|Pho86p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG27
  • YLR100W
    		•  The BioGRID Database Seperator 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs|Erg27p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Baudry K (2001)
    Affinity Capture-Western
    hit Mo C (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE24
  • AFC1
  • PIO2
  • YJR117W
    		•  The BioGRID Database Seperator Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans|Ste24p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUE1
  • KIS4
  • YMR264W
    		•  The BioGRID Database Seperator Cue1p|Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    Phenotypic Enhancement
    bait Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG11
  • CYP51
  • YHR007C
    		•  The BioGRID Database Seperator Erg11p|Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    Synthetic Rescue
    hit Gachotte D (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ORM2
  • YLR350W
    		•  The BioGRID Database Seperator Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum|Orm2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG3
  • PSO6
  • SYR1
  • YLR056W
    		•  The BioGRID Database Seperator C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources|Erg3p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    Phenotypic Enhancement
    hit Schuldiner M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSC13
  • YDL015C
    		•  The BioGRID Database Seperator Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p|Tsc13p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG25
  • YGR060W
    		•  The BioGRID Database Seperator C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol|Erg25p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BAP3
  • PAP1
  • YDR046C
    		•  The BioGRID Database Seperator Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine|Bap3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHR3
  • APF1
  • YDL212W
    		•  The BioGRID Database Seperator Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface|Shr3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERP2
  • YAL007C
    		•  The BioGRID Database Seperator Erp2p|Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UIP3
  • YAR027W
    		•  The BioGRID Database Seperator Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family|Uip3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AGP1
  • YCC5
  • YCL025C
    		•  The BioGRID Database Seperator Agp1p|Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR159W
  • IFA38
    		•  The BioGRID Database Seperator Ifa38p|Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FEN1
  • ELO2
  • GNS1
  • VBM2
  • YCR034W
    		•  The BioGRID Database Seperator Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway|Fen1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERD2
  • YBL040C
    		•  The BioGRID Database Seperator Erd2p|HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG1
  • YBR110W
    		•  The BioGRID Database Seperator Alg1p|Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT6
  • YDR343C
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3|Hxt6p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ILM1
  • YJR118C
    		•  The BioGRID Database Seperator Ilm1p|Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC2
  • SPY1
  • YML055W
    		•  The BioGRID Database Seperator Spc2p|Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RBD2
  • YPL246C
    		•  The BioGRID Database Seperator Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p|Rbd2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KRE27
  • YIL027C
    		•  The BioGRID Database Seperator Kre27p|Protein of unknown function; null mutant shows K1 killer toxin resistance; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR134W
  • ERG29
    		•  The BioGRID Database Seperator Erg29p|Protein that binds to and regulates Erg25p; localized to the ER; null mutant is viable in a respiratory defective background; synthetic lethal with mmt1 and mmt2 mutations; highly conserved in ascomycetes; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERV25
  • YML012W
    		•  The BioGRID Database Seperator Erv25p|Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPZ1
  • YML016C
    		•  The BioGRID Database Seperator Ppz1p|Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC61
  • YLR378C
    		•  The BioGRID Database Seperator Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER|Sec61p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG26
  • YGL001C
    		•  The BioGRID Database Seperator C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis|Erg26p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Baudry K (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERP1
  • YAR002C-A
    		•  The BioGRID Database Seperator Erp1p|Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR241C
  • YBR241C
    		•  The BioGRID Database Seperator Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene|Ybr241cp; protein coding
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSH1
  • YBR283C
    		•  The BioGRID Database Seperator Ssh1p|Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential; protein coding
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPC1
  • YBR183W
    		•  The BioGRID Database Seperator Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance|Ypc1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EMP24
  • BST2
  • YGL200C
    		•  The BioGRID Database Seperator Emp24p|Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAS3
  • YMR215W
    		•  The BioGRID Database Seperator Gas3p|Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOL003C
  • PFA4
    		•  The BioGRID Database Seperator Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases|Pfa4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMG1
  • YML075C
    		•  The BioGRID Database Seperator Hmg1p|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GSF2
  • ECM6
  • YML048W
    		•  The BioGRID Database Seperator ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression|Gsf2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAS2
  • YLR343W
    		•  The BioGRID Database Seperator 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p|Gas2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUR4
  • APA1
  • ELO3
  • SRE1
  • YLR372W
    		•  The BioGRID Database Seperator Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis|Sur4p; protein coding
    Gene Ontology: