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BioGRID | Network Layout for HSF1 for Saccharomyces cerevisiae
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HSF1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: EXA3, MAS3, YGL073W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Hsf1p|Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with HSF1

HSF1 was identified with 18 protein interactions and 34 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SNF1
  • CAT1
  • CCR1
  • GLC2
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis|Snf1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hahn JS (2004)
    Biochemical Activity
    bait Hahn JS (2004)
    bait Lee P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKN7
  • BRY1
  • POS9
  • YHR206W
    		•  The BioGRID Database Seperator Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation|Skn7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Raitt DC (2000)
    Dosage Rescue
    hit Raitt DC (2000)
    Phenotypic Enhancement
    bait Raitt DC (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAC1
  • YOR178C
    		•  The BioGRID Database Seperator Gac1p|Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Lin JT (1999)
    Affinity Capture-Western
    hit Lin JT (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Halladay JT (1995)
    bait Nelson RJ (1992)
    Phenotypic Suppression
    bait Bandhakavi S (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Zarzov P (1997)
    hit Truman AW (2007)
    Phenotypic Suppression
    hit Morano KA (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN2
  • YMR037C
    		•  The BioGRID Database Seperator Msn2p|Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Erkina TY (2008)
    Synthetic Rescue
    hit Bandhakavi S (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CMK2
  • YOL016C
    		•  The BioGRID Database Seperator Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II|Cmk2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Lee P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KNS1
  • YLL019C
    		•  The BioGRID Database Seperator Kns1p|Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Lee P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSB2
  • YG103
  • YNL209W
    		•  The BioGRID Database Seperator Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1|Ssb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Bonner JJ (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CMK1
  • YFR014C
    		•  The BioGRID Database Seperator Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II|Cmk1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Lee P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAK1
  • YJL141C
    		•  The BioGRID Database Seperator Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal|Yak1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Lee P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC6
  • YJL194W
    		•  The BioGRID Database Seperator Cdc6p|Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSB1
  • YG101
  • YDL229W
    		•  The BioGRID Database Seperator Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p|Ssb1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Bonner JJ (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN4
  • YKL062W
    		•  The BioGRID Database Seperator Msn4p|Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Erkina TY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR419W
  • YLR419W
    		•  The BioGRID Database Seperator Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene|Ylr419wp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF2
  • GAM1
  • HAF1
  • SWI2
  • YOR290C
    		•  The BioGRID Database Seperator Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p|Snf2p; protein coding
    Gene Ontology: [View List]
    Co-localization
    hit Erkina TY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKT5
  • CAL2
  • CHS4
  • CSD4
  • YBL061C
    		•  The BioGRID Database Seperator Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation|Skt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLT2
  • BYC2
  • MPK1
  • SLK2
  • YHR030C
    		•  The BioGRID Database Seperator Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway|Slt2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Truman AW (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR146C
  • YGR146C
    		•  The BioGRID Database Seperator Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant|Ygr146cp; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS1
  • CES1
  • CKM1
  • NRC1
  • YMR273C
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export|Zds1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTS1
  • SCS1
  • YOR014W
    		•  The BioGRID Database Seperator B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A|Rts1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC40
  • PRP17
  • SLT15
  • SLU4
  • YDR364C
    		•  The BioGRID Database Seperator Cdc40p|Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Kaplan Y (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS2
  • CES4
  • YML109W
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p|Zds2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLN3
  • YER040W
    		•  The BioGRID Database Seperator Gln3p|Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Bandhakavi S (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KRE6
  • CWH48
  • YPR159W
    		•  The BioGRID Database Seperator Kre6p|Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functionally redundant with Skn1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIR3
  • CCW8
  • YKL163W
    		•  The BioGRID Database Seperator O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway|Pir3p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Bandhakavi S (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRO2
  • YBR054W
    		•  The BioGRID Database Seperator Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p|Yro2p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Bandhakavi S (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FPR1
  • FKB1
  • RBP1
  • YNL135C
    		•  The BioGRID Database Seperator Fpr1p|Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Bandhakavi S (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Morano KA (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUP2
  • ACE1
  • YGL166W
    		•  The BioGRID Database Seperator Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations|Cup2p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Silar P (1991)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Liu XD (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STI1
  • YOR027W
    		•  The BioGRID Database Seperator Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Liu XD (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCH9
  • KOM1
  • YHR205W
    		•  The BioGRID Database Seperator Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB|Sch9p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Morano KA (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA2
  • YG102
  • YLL024C
    		•  The BioGRID Database Seperator ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall|Ssa2p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Nelson RJ (1992)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • HSL5
  • SRM5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates|Cdc28p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Zarzov P (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDE2
  • SRA5
  • YOR360C
    		•  The BioGRID Database Seperator High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon|Pde2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM15
  • TAK1
  • YFL033C
    		•  The BioGRID Database Seperator Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase|Rim15p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ROM2
  • YLR371W
    		•  The BioGRID Database Seperator GDP/GTP exchange protein (GEP) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEP|Rom2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MID2
  • KAI1
  • YLR332W
    		•  The BioGRID Database Seperator Mid2p|O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WSC2
  • STA3
  • YNL283C
    		•  The BioGRID Database Seperator Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response|Wsc2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLG1
  • HCS77
  • WSC1
  • YOR008C
    		•  The BioGRID Database Seperator Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response|Slg1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EXG1
  • BGL1
  • YLR300W
    		•  The BioGRID Database Seperator Exg1p|Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Imazu H (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator