The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for INO80 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

INO80

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YGL150C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 12 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with INO80

INO80 was identified with 90 protein interactions and 47 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 ARP4
  • ACT3
  • YJL081C
    		•  The BioGRID Database Seperator Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Shen X (2003) [9]
    hit Szerlong H (2008) [23]
    Affinity Capture-MS
    hit Mizuguchi G (2004) [36]
    hit Shen X (2000) [12]
    bait Downs JA (2004) [29]
    hit Morrison AJ (2004) [73]
    bait Krogan NJ (2006) [7079]
    hit Shen X (2004) [6]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVB2
  • TIH2
  • TIP49B
  • TIP49
  • YPL235W
    		•  The BioGRID Database Seperator Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    hit Mizuguchi G (2004) [36]
    bait/hit Shen X (2000) [12]
    hit Morrison AJ (2004) [73]
    hit Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Shen X (2004) [6]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Shen X (2000) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP8
  • YOR141C
    		•  The BioGRID Database Seperator Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Shen X (2003) [9]
    hit Szerlong H (2008) [23]
    Affinity Capture-MS
    hit Mizuguchi G (2004) [36]
    hit Shen X (2000) [12]
    bait/hit Morrison AJ (2004) [73]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Shen X (2004) [6]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHP10
  • HMO2
  • YDL002C
    		•  The BioGRID Database Seperator Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    hit Mizuguchi G (2004) [36]
    bait/hit Morrison AJ (2004) [73]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Two-hybrid
    hit Uetz P (2000) [875]
    Affinity Capture-Western
    hit Shen X (2003) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Shen X (2003) [9]
    hit Szerlong H (2008) [23]
    Affinity Capture-MS
    hit Mizuguchi G (2004) [36]
    hit Shen X (2000) [12]
    hit Morrison AJ (2004) [73]
    hit Gavin AC (2006) [7592]
    hit Shen X (2004) [6]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF14
  • SWP29
  • TFG3
  • ANC1
  • YPL129W
    		•  The BioGRID Database Seperator Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Sanders SL (2002) [483]
    hit Mizuguchi G (2004) [36]
    hit Morrison AJ (2004) [73]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Two-hybrid
    bait Kabani M (2005) [12]
    Affinity Capture-Western
    hit Kabani M (2005) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVB1
  • TIP49A
  • TIP48
  • TIH1
  • YDR190C
    		•  The BioGRID Database Seperator Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Mizuguchi G (2004) [36]
    hit Shen X (2000) [12]
    hit Morrison AJ (2004) [73]
    bait/hit Gavin AC (2006) [7592]
    hit Shen X (2004) [6]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES3
  • YLR052W
    		•  The BioGRID Database Seperator Subunit of the INO80 chromatin remodeling complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Shen X (2003) [9]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP5
  • YNL059C
    		•  The BioGRID Database Seperator Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Mizuguchi G (2004) [36]
    hit Shen X (2000) [12]
    bait/hit Gavin AC (2006) [7592]
    hit Shen X (2004) [6]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES1
  • YFL013C
    		•  The BioGRID Database Seperator Subunit of the INO80 chromatin remodeling complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES5
  • YER092W
    		•  The BioGRID Database Seperator Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Morrison AJ (2004) [73]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES6
  • YEL044W
    		•  The BioGRID Database Seperator Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF2
  • YNL030W
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GFA1
  • YKL104C
    		•  The BioGRID Database Seperator Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHF1
  • YBR009C
    		•  The BioGRID Database Seperator One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT1
  • LPF4
  • BUR3
  • YPL082C
    		•  The BioGRID Database Seperator Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Arnett DR (2008) [91]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IES4
  • YOR189W
    		•  The BioGRID Database Seperator Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET10
  • YFR030W
    		•  The BioGRID Database Seperator Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF1
  • TAF130
  • TAF145
  • YGR274C
    		•  The BioGRID Database Seperator TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation, has histone acetyltransferase activity, involved in promoter binding and G1/S progression
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKH2
  • YNL068C
    		•  The BioGRID Database Seperator Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GDS1
  • YOR355W
    		•  The BioGRID Database Seperator Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT2
  • YNL031C
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF12
  • TAF61
  • TAF68
  • YDR145W
    		•  The BioGRID Database Seperator Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Sanders SL (2002) [483]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA1
  • H2A1
  • SPT11
  • YDR225W
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • SIN2
  • BUR5
  • YBR010W
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB2
  • YBL002W
    		•  The BioGRID Database Seperator One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTB1
  • SPT12
  • YDR224C
    		•  The BioGRID Database Seperator One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTA2
  • H2A2
  • YBL003C
    		•  The BioGRID Database Seperator One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA34
  • YJL148W
    		•  The BioGRID Database Seperator RNA polymerase I subunit A34.5
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOS4
  • YIL112W
    		•  The BioGRID Database Seperator Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL16A
  • RPL13
  • YIL133C
    		•  The BioGRID Database Seperator N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAA1
  • YDR071C
    		•  The BioGRID Database Seperator Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS0B
  • YST2
  • YLR048W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTH1
  • YDR001C
    		•  The BioGRID Database Seperator Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG18
  • AUT10
  • SVP1
  • CVT18
  • YFR021W
    		•  The BioGRID Database Seperator Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CUL3
  • YGR003W
    		•  The BioGRID Database Seperator Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RME1
  • CSP1
  • YGR044C
    		•  The BioGRID Database Seperator Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEF1
  • YGR058W
    		•  The BioGRID Database Seperator Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COX7
  • YMR256C
    		•  The BioGRID Database Seperator Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS30B
  • YOR182C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LIP5
  • YOR196C
    		•  The BioGRID Database Seperator Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMA2
  • YPL036W
    		•  The BioGRID Database Seperator Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX5
  • HEX3
  • YDL013W
    		•  The BioGRID Database Seperator Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM3
  • PTH1
  • YOR106W
    		•  The BioGRID Database Seperator Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD21
  • YOR29-29
  • UTP16
  • YOR078W
    		•  The BioGRID Database Seperator Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSR1
  • SFH2
  • YLR380W
    		•  The BioGRID Database Seperator Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATP10
  • YLR393W
    		•  The BioGRID Database Seperator Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAM37
  • MAS37
  • TOM37
  • PET3027
  • YMR060C
    		•  The BioGRID Database Seperator Component of the mitochondrial outer membrane sorting and assembly machinery (SAM) complex; required for the sorting of some proteins to the outer membrane after import by the TOM complex
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INO4
  • YOL108C
    		•  The BioGRID Database Seperator Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSC2
  • YLR357W
    		•  The BioGRID Database Seperator Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
    Gene Ontology: [View List]
    Positive Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRF5
  • YNL299W
    		•  The BioGRID Database Seperator Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSY2
  • YNL201C
    		•  The BioGRID Database Seperator Putative subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and the regulatory subunit Psy4p; required for cisplatin and oxaliplatin resistance; localizes to nucleus
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YML119W
  • YML119W
    		•  The BioGRID Database Seperator Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF3
  • YPR023C
    		•  The BioGRID Database Seperator Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAD1
  • YGL086W
    		•  The BioGRID Database Seperator Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB3
  • YBR278W
    		•  The BioGRID Database Seperator Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET5
  • YHR207C
    		•  The BioGRID Database Seperator Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ROX3
  • NUT3
  • MED19
  • SSN7
  • YBL093C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSN3
  • NUT7
  • GIG2
  • CDK8
  • YPL042C
    		•  The BioGRID Database Seperator Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN1
  • YGL195W
    		•  The BioGRID Database Seperator Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL4
  • GAL81
  • YPL248C
    		•  The BioGRID Database Seperator DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN5
  • SWI9
  • ADA4
  • YGR252W
    		•  The BioGRID Database Seperator Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Barbaric S (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTR2
  • YGR163W
    		•  The BioGRID Database Seperator Cytoplasmic GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; subunit of EGO complex, which is involved in microautophagy regulation, and of GSE complex, required for sorting of Gap1p; homolog of human RagC and RagD
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Sekiguchi T (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ETR1
  • MRF1'
  • MRF1
  • YBR026C
    		•  The BioGRID Database Seperator 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS6B
  • RPS102
  • RPS101
  • LPG18
  • YBR181C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCL074W
  • YCL074W
    		•  The BioGRID Database Seperator pseudo
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GTR1
  • YML121W
    		•  The BioGRID Database Seperator Cytoplasmic GTP binding protein and negative regulator, with homolog Gtr2p, of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport; has homology to human RagA and RagB
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Sekiguchi T (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD55
  • YDR076W
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF2
  • SWI2
  • GAM1
  • TYE3
  • YOR290C
    		•  The BioGRID Database Seperator Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Barbaric S (2007) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD54
  • XRS1
  • YGL163C
    		•  The BioGRID Database Seperator DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Morrison AJ (2004) [73]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN4
  • UFD5
  • SON1
  • YDL020C
    		•  The BioGRID Database Seperator Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.