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BioGRID | Network Layout for CHC1 for Saccharomyces cerevisiae
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CHC1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SWA5, YGL206C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Chc1p|Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CHC1

CHC1 was identified with 61 protein interactions and 47 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 CLC1
  • SCD4
  • YGR167W
    		•  The BioGRID Database Seperator Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component|Clc1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    bait Deloche O (2001)
    hit Newpher TM (2006)
    Two-hybrid
    hit Henry KR (2002)
    bait Newpher TM (2006)
    Reconstituted Complex
    hit Newpher TM (2006)
    Dosage Rescue
    bait/hit Huang KM (1997)
    bait Chu DS (1996)
    Phenotypic Suppression
    hit Newpher TM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APL2
  • YKL135C
    		•  The BioGRID Database Seperator Apl2p|Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Yeung BG (2001)
    bait Yeung BG (1999)
    Synthetic Growth Defect
    bait/hit Yeung BG (2001)
    bait/hit Yeung BG (1999)
    hit Rad MR (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA2
  • END4
  • MOP2
  • YNL243W
    		•  The BioGRID Database Seperator Sla2p|Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Henry KR (2002)
    Co-localization
    hit Newpher TM (2005)
    PCA
    hit Tarassov K (2008)
    Synthetic Lethality
    hit Henry KR (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GGA2
  • YHR108W
    		•  The BioGRID Database Seperator Gga2p|Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    Affinity Capture-Western
    bait Costaguta G (2001)
    Reconstituted Complex
    bait Mullins C (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENT1
  • YDL161W
    		•  The BioGRID Database Seperator Ent1p|Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Baggett JJ (2003)
    bait Wendland B (1999)
    Co-localization
    hit Newpher TM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GGA1
  • YDR358W
    		•  The BioGRID Database Seperator Gga1p|Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Costaguta G (2001)
    Reconstituted Complex
    bait Mullins C (2001)
    Synthetic Growth Defect
    bait Costaguta G (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APL4
  • YPR029C
    		•  The BioGRID Database Seperator Apl4p|Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Yeung BG (2001)
    PCA
    bait/hit Tarassov K (2008)
    Synthetic Growth Defect
    hit Yeung BG (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCD5
  • FTB1
  • YOR329C
    		•  The BioGRID Database Seperator Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1|Scd5p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Henry KR (2002)
    hit Nelson KK (1996)
    Phenotypic Enhancement
    hit Henry KR (2002)
    Synthetic Lethality
    bait Henry KR (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APS1
  • YAP19
  • YLR170C
    		•  The BioGRID Database Seperator Aps1p|Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Copic A (2007)
    Synthetic Growth Defect
    hit Phan HL (1994)
    hit Yeung BG (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWA2
  • AUX1
  • BUD24
  • YDR320C
    		•  The BioGRID Database Seperator Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles|Swa2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Pishvaee B (2000)
    Reconstituted Complex
    bait Xiao J (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENT3
  • YJR125C
    		•  The BioGRID Database Seperator Ent3p|Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Friant S (2003)
    Affinity Capture-MS
    bait Copic A (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAP1802
  • YGR241C
    		•  The BioGRID Database Seperator Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family|Yap1802p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wendland B (1998)
    Co-localization
    hit Newpher TM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAP1801
  • YHR161C
    		•  The BioGRID Database Seperator Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family|Yap1801p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wendland B (1998)
    Co-localization
    hit Newpher TM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENT5
  • YDR153C
    		•  The BioGRID Database Seperator Ent5p|Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Fernandez GE (2006)
    Affinity Capture-MS
    bait Copic A (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LYS12
  • LYS10
  • LYS11
  • YIL094C
    		•  The BioGRID Database Seperator Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate|Lys12p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LAS17
  • BEE1
  • YOR181W
    		•  The BioGRID Database Seperator Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)|Las17p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENT2
  • YLR206W
    		•  The BioGRID Database Seperator Ent2p|Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Baggett JJ (2003)
    Co-localization
    hit Newpher TM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait/hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP1
  • VPS10
  • VPT1
  • YBL017C
    		•  The BioGRID Database Seperator Pep1p|Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    Phenotypic Enhancement
    hit Deloche O (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INP53
  • SJL3
  • SOP2
  • YOR109W
    		•  The BioGRID Database Seperator Inp53p|Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in a TGN (trans Golgi network)-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ha SA (2003)
    Synthetic Growth Defect
    hit Bensen ES (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APM1
  • YAP54
  • YPL259C
    		•  The BioGRID Database Seperator Apm1p|Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Stepp JD (1995)
    hit Yeung BG (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF1
  • YDL192W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p|Arf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Gall WE (2002)
    bait Chen CY (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP12
  • VPL6
  • VPS6
  • VPT13
  • YOR036W
    		•  The BioGRID Database Seperator Pep12p|Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Bensen ES (2000)
    Phenotypic Enhancement
    hit Deloche O (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJL207C
  • LAA1
    		•  The BioGRID Database Seperator AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene|Laa1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Fernandez GE (2006)
    Phenotypic Enhancement
    hit Fernandez GE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     INO1
  • APR1
  • YJL153C
    		•  The BioGRID Database Seperator Ino1p|Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AGE2
  • SAT2
  • YIL044C
    		•  The BioGRID Database Seperator ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif|Age2p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC18
  • YLR370C
    		•  The BioGRID Database Seperator Arc18p|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIS1
  • YNL007C
    		•  The BioGRID Database Seperator Sis1p|Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHB1
  • YHB4
  • YGR234W
    		•  The BioGRID Database Seperator Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses|Yhb1p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STI1
  • YOR027W
    		•  The BioGRID Database Seperator Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS27
  • DID7
  • GRD11
  • SSV17
  • YNR006W
    		•  The BioGRID Database Seperator Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)|Vps27p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bilodeau PS (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCN3
  • AAS2
  • YKR026C
    		•  The BioGRID Database Seperator Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression|Gcn3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)