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BioGRID | Network Layout for CDC28 for Saccharomyces cerevisiae
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CDC28

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: CDK1, SRM5, HSL5, YBR160W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 36 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CDC28

CDC28 was identified with 406 protein interactions and 182 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 CLN2
  • YPL256C
    		•  The BioGRID Database Seperator G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Ho Y (2002) [3666]
    bait Archambault V (2004) [74]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    hit Kito K (2008) [15]
    Affinity Capture-Western
    hit Ceccarelli E (2001) [3]
    bait Peter M (1994) [3]
    bait Wang H (2004) [7]
    bait Deshaies RJ (1995) [1]
    bait Lim HH (1996) [2]
    bait Miller ME (2005) [4]
    bait Kono K (2008) [5]
    Reconstituted Complex
    hit Lanker S (1996) [2]
    hit Tyers M (1993) [7]
    Biochemical Activity
    hit Lanker S (1996) [2]
    Dosage Rescue
    hit Reed SI (1989) [3]
    hit Queralt E (2004) [4]
    Synthetic Rescue
    bait Levine K (1998) [1]
    bait Miller ME (2005) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    bait Honey S (2001) [21]
    bait Archambault V (2004) [74]
    bait Krogan NJ (2006) [7079]
    hit Kito K (2008) [15]
    Affinity Capture-Western
    bait Shellman YG (1999) [2]
    bait Bailly E (2003) [2]
    bait Schwab M (2001) [10]
    bait Ross KE (2000) [2]
    bait Kaiser P (1999) [16]
    bait Lim HH (1996) [2]
    bait Hu F (2008) [5]
    Biochemical Activity
    hit Hu F (2008) [5]
    Dosage Rescue
    hit Ahn SH (2001) [6]
    hit Surana U (1991) [7]
    hit Tobe BT (2009) [11]
    Synthetic Lethality
    bait/hit Surana U (1991) [7]
    bait Ahn SH (2001) [6]
    hit Tobe BT (2009) [11]
    Phenotypic Enhancement
    hit Tobe BT (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKS1
  • YBR135W
    		•  The BioGRID Database Seperator Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002) [3400]
    bait Ho Y (2002) [3666]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    hit Kito K (2008) [15]
    Two-hybrid
    bait/hit Ito T (2001) [1585]
    hit Wong J (2007) [604]
    hit Kim SH (2009) [4]
    Affinity Capture-Western
    hit Ceccarelli E (2001) [3]
    hit Kaiser P (1999) [16]
    bait Rudner AD (2000) [17]
    bait Hadwiger JA (1989) [1]
    Reconstituted Complex
    bait Reynard GJ (2000) [2]
    Co-purification
    hit Kaiser P (1999) [16]
    Dosage Rescue
    hit Reed SI (1989) [3]
    hit Tobe BT (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAK1
  • CIV1
  • YFL029C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Thuret JY (1996) [3]
    Reconstituted Complex
    bait Thuret JY (1996) [3]
    Biochemical Activity
    bait Ross KE (2000) [2]
    bait Chun KT (1997) [1]
    bait Thuret JY (1996) [3]
    bait Kaldis P (1996) [3]
    Two-hybrid
    hit Wong J (2007) [604]
    hit Kim SH (2009) [4]
    Dosage Rescue
    hit Kitazono AA (2002) [1]
    Phenotypic Enhancement
    bait Espinoza FH (1998) [3]
    Synthetic Rescue
    bait Ceccarelli E (2001) [3]
    bait Cross FR (1998) [1]
    bait Brands A (2008) [3]
    Phenotypic Suppression
    hit Cross FR (2000) [1]
    bait Schmidt M (2008) [3]
    hit Kim SH (2009) [4]
    Synthetic Lethality
    hit Kim SH (2009) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB3
  • YDL155W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Shellman YG (1999) [2]
    bait Espinoza FH (1994) [3]
    Affinity Capture-MS
    bait Archambault V (2004) [74]
    bait Krogan NJ (2006) [7079]
    hit Collins SR (2007) [9064]
    hit Kito K (2008) [15]
    Reconstituted Complex
    hit Grandin N (1993) [3]
    Two-hybrid
    hit Wong J (2007) [604]
    Dosage Rescue
    hit Surana U (1991) [7]
    Phenotypic Enhancement
    hit Segal M (2000) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAR1
  • YJL157C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Peter M (1993) [3]
    bait Gartner A (1998) [2]
    Affinity Capture-Western
    hit Tyers M (1993) [7]
    hit Peter M (1994) [3]
    Reconstituted Complex
    hit Tyers M (1993) [7]
    Biochemical Activity
    hit Henchoz S (1997) [1]
    hit Peter M (1993) [3]
    hit Tyers M (1993) [7]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN3
  • WHI1
  • FUN10
  • DAF1
  • YAL040C
    		•  The BioGRID Database Seperator G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wijnen H (2002) [5]
    hit Tyers M (1992) [2]
    bait Miller ME (2005) [4]
    Biochemical Activity
    hit Yaglom J (1995) [1]
    hit Tyers M (1992) [2]
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Wong J (2007) [604]
    Synthetic Rescue
    bait Cross FR (1989) [1]
    bait Miller ME (2005) [4]
    Phenotypic Enhancement
    bait Cross FR (1993) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Verma R (2001) [3]
    Biochemical Activity
    hit Skowyra D (1997) [8]
    hit Petroski MD (2003) [5]
    hit Ubersax JA (2003) [369]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    hit Kito K (2008) [15]
    Phenotypic Enhancement
    hit Rice LM (2005) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC6
  • YJL194W
    		•  The BioGRID Database Seperator Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Elsasser S (1996) [3]
    bait Archambault V (2003) [19]
    bait Weinreich M (2001) [2]
    bait Calzada A (2000) [1]
    Reconstituted Complex
    hit Elsasser S (1999) [3]
    hit Elsasser S (1996) [3]
    Biochemical Activity
    hit Elsasser S (1996) [3]
    hit Loog M (2005) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWE1
  • WEE1
  • YJL187C
    		•  The BioGRID Database Seperator Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Harvey SL (2005) [3]
    Biochemical Activity
    hit McMillan JN (2002) [6]
    hit Harvey SL (2005) [3]
    hit Ubersax JA (2003) [369]
    hit Asano S (2005) [4]
    bait/hit Hu F (2008) [5]
    Synthetic Rescue
    hit Ahn SH (2001) [6]
    hit Okuzaki D (2003) [5]
    hit Tobe BT (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN1
  • YMR199W
    		•  The BioGRID Database Seperator G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Ho Y (2002) [3666]
    hit Gavin AC (2006) [7592]
    hit Kito K (2008) [15]
    Reconstituted Complex
    hit Tyers M (1993) [7]
    Two-hybrid
    hit Wong J (2007) [604]
    Dosage Rescue
    hit Reed SI (1989) [3]
    Synthetic Rescue
    hit Ahn SH (2001) [6]
    Dosage Growth Defect
    hit Tobe BT (2009) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB5
  • YPR120C
    		•  The BioGRID Database Seperator B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Cross FR (2000) [2]
    Reconstituted Complex
    hit Verma R (2001) [3]
    Affinity Capture-MS
    bait Archambault V (2004) [74]
    bait Krogan NJ (2006) [7079]
    hit Kito K (2008) [15]
    Phenotypic Enhancement
    hit Segal M (1998) [3]
    hit Rice LM (2005) [10]
    hit Segal M (2000) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDH1
  • HCT1
  • YGL003C
    		•  The BioGRID Database Seperator Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002) [3666]
    Affinity Capture-Western
    bait Schwab M (2001) [10]
    Biochemical Activity
    hit Jaspersen SL (1999) [2]
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    hit Crasta K (2008) [12]
    Synthetic Lethality
    hit Rudner AD (2000) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC5
  • PKX2
  • MSD2
  • YMR001C
    		•  The BioGRID Database Seperator Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate
    Gene Ontology: [View List]
    Two-hybrid
    hit Mort-Bontemps-Soret M (2002) [15]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Co-localization
    bait Asano S (2005) [4]
    Synthetic Lethality
    hit Rudner AD (2000) [12]
    Phenotypic Suppression
    hit Crasta K (2008) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB4
  • YLR210W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Grandin N (1993) [3]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    Two-hybrid
    hit Wong J (2007) [604]
    Dosage Rescue
    hit Surana U (1991) [7]
    Phenotypic Enhancement
    hit Segal M (2000) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NDD1
  • YOR372C
    		•  The BioGRID Database Seperator Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
    Gene Ontology: [View List]
    Biochemical Activity
    hit Darieva Z (2003) [1]
    hit Reynolds D (2003) [3]
    hit Ubersax JA (2003) [369]
    Dosage Rescue
    hit Loy CJ (1999) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI5
  • YOR083W
    		•  The BioGRID Database Seperator Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
    Gene Ontology: [View List]
    Biochemical Activity
    hit Costanzo M (2004) [8]
    hit Ubersax JA (2003) [369]
    bait Huang D (2009) [28]
    Synthetic Rescue
    hit Takahata S (2009) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Manderson EN (2008) [4]
    Synthetic Lethality
    bait Bouquin N (2000) [10]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB1
  • SCB1
  • YGR108W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Grandin N (1993) [3]
    Affinity Capture-MS
    hit Kito K (2008) [15]
    Dosage Rescue
    hit Ahn SH (2001) [6]
    hit Surana U (1991) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STB1
  • YNL309W
    		•  The BioGRID Database Seperator Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated
    Gene Ontology: [View List]
    Biochemical Activity
    hit Costanzo M (2003) [3]
    hit Ho Y (1999) [3]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI4
  • ART1
  • YER111C
    		•  The BioGRID Database Seperator DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Siegmund RF (1996) [4]
    Biochemical Activity
    hit Amon A (1993) [2]
    Two-hybrid
    hit Manderson EN (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDS1
  • YDR113C
    		•  The BioGRID Database Seperator Securin that inhibits anaphase by binding separin Esp1p, also blocks cyclin destruction and mitotic exit, essential for cell cycle arrest in mitosis in the presence of DNA damage or aberrant mitotic spindles; also present in meiotic nuclei
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Agarwal R (2002) [3]
    Biochemical Activity
    hit Agarwal R (2002) [3]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI6
  • PSL8
  • SDS11
  • YLR182W
    		•  The BioGRID Database Seperator Transcription cofactor, forms complexes with DNA-binding proteins Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; localization regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Geymonat M (2004) [2]
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Manderson EN (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAR9
  • YPL269W
    		•  The BioGRID Database Seperator Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
    Gene Ontology: [View List]
    Two-hybrid
    hit Maekawa H (2003) [7]
    Biochemical Activity
    hit Liakopoulos D (2003) [4]
    hit Maekawa H (2003) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FKH2
  • YNL068C
    		•  The BioGRID Database Seperator Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Pic-Taylor A (2004) [5]
    Biochemical Activity
    hit Pic-Taylor A (2004) [5]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ORC6
  • YHR118C
    		•  The BioGRID Database Seperator Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Weinreich M (2001) [2]
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC23
  • YHR166C
    		•  The BioGRID Database Seperator Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
    Gene Ontology: [View List]
    Biochemical Activity
    hit Rudner AD (2000) [17]
    Synthetic Lethality
    bait Jones AL (2000) [5]
    hit Rudner AD (2000) [12]
    Phenotypic Suppression
    hit Irniger S (1995) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC7
  • SAS1
  • LSD6
  • YDL017W
    		•  The BioGRID Database Seperator DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
    Gene Ontology: [View List]
    Biochemical Activity
    hit Yoon HJ (1993) [1]
    Dosage Lethality
    bait Ohtoshi A (1996) [1]
    Synthetic Lethality
    hit Zarzov P (1997) [5]
    Dosage Rescue
    hit Kitada K (1993) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN3
  • SUN2
  • YER021W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kaiser P (1999) [16]
    Co-purification
    hit Kaiser P (1999) [16]
    Synthetic Growth Defect
    hit Kaiser P (1999) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAR3
  • OSR11
  • YPR141C
    		•  The BioGRID Database Seperator Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Wong J (2007) [604]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSA1
  • YOR29-17
  • YOR066W
    		•  The BioGRID Database Seperator Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Wong J (2007) [604]
    Synthetic Growth Defect
    hit Li JM (2008) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPC110
  • NUF1
  • XCM1
  • YDR356W
    		•  The BioGRID Database Seperator Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    Phenotypic Suppression
    hit Huisman SM (2007) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIN4
  • ERC47
  • YDR507C
    		•  The BioGRID Database Seperator Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Okuzaki D (1997) [3]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Phenotypic Enhancement
    bait Okuzaki D (1997) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTE1
  • MSI2
  • YAL024C
    		•  The BioGRID Database Seperator Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
    Gene Ontology: [View List]
    Biochemical Activity
    hit Jensen S (2002) [2]
    hit Ubersax JA (2003) [369]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • PSO8
  • YGL058W
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Koltovaia NA (1998) [2]
    hit Koltovaya NA (1998) [2]
    hit Enserink JM (2009) [35]
    Synthetic Growth Defect
    hit Enserink JM (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLT2
  • BYC2
  • MPK1
  • SLK2
  • YHR030C
    		•  The BioGRID Database Seperator Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
    Gene Ontology: [View List]
    Biochemical Activity
    hit Zarzov P (1996) [3]
    Synthetic Lethality
    bait Mazzoni C (1993) [3]
    hit Zarzov P (1997) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC37
  • SMO1
  • YDR168W
    		•  The BioGRID Database Seperator Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Mort-Bontemps-Soret M (2002) [15]
    Dosage Rescue
    bait Mort-Bontemps-Soret M (2002) [15]
    Synthetic Lethality
    bait Mort-Bontemps-Soret M (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEN1
  • YER041W
    		•  The BioGRID Database Seperator Protein of unknown function, has similarity to endonuclease Rth1p; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM3
  • YEL032W
    		•  The BioGRID Database Seperator Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPB2
  • YPR175W
    		•  The BioGRID Database Seperator Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Kesti T (2004) [3]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWI5
  • YDR146C
    		•  The BioGRID Database Seperator Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACM1
  • YPL267W
    		•  The BioGRID Database Seperator Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    hit Hall MC (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKG3
  • YLR187W
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS2
  • MMC1
  • YGL075C
    		•  The BioGRID Database Seperator Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCL7
  • YIL050W
    		•  The BioGRID Database Seperator Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLD2
  • DRC1
  • YKL108W
    		•  The BioGRID Database Seperator Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    hit Masumoto H (2002) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DDC1
  • YPL194W
    		•  The BioGRID Database Seperator DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CNN1
  • YFR046C
    		•  The BioGRID Database Seperator Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIN1
  • YDR130C
    		•  The BioGRID Database Seperator Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ORC2
  • SIR5
  • RRR1
  • YBR060C
    		•  The BioGRID Database Seperator Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Loog M (2005) [11]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MIH1
  • YMR036C
    		•  The BioGRID Database Seperator Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    hit Pal G (2008) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUS1
  • SOP10
  • YLR425W
    		•  The BioGRID Database Seperator Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    hit Kono K (2008) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO2
  • BAS2
  • GRF10
  • YDL106C
    		•  The BioGRID Database Seperator Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
    Gene Ontology: [View List]
    Two-hybrid
    hit Liu C (2000) [4]
    Biochemical Activity
    hit Liu C (2000) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFG1
  • YOR315W
    		•  The BioGRID Database Seperator Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE1
  • YER012W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Babbitt SE (2005) [21]
    Co-purification
    hit Kaiser P (1999) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC13
  • EST4
  • YDL220C
    		•  The BioGRID Database Seperator Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
    Gene Ontology: [View List]
    Biochemical Activity
    hit Tseng SF (2009) [2]
    bait Li S (2009) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASH1
  • YKL185W
    		•  The BioGRID Database Seperator Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Li Y () [1]
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET10
  • YFR030W
    		•  The BioGRID Database Seperator Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • YTA3
  • CIM5
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Kaiser P (1999) [16]
    Co-purification
    hit Kaiser P (1999) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPT5
  • HTR1
  • UTH4
  • PUF5
  • YGL178W
    		•  The BioGRID Database Seperator Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Chen T (1997) [12]
    Two-hybrid
    bait/hit Chen T (1997) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSL1
  • NIK1
  • YKL101W
    		•  The BioGRID Database Seperator Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Burton JL (2000) [7]
    Phenotypic Enhancement
    hit Tanaka S (1996) [1]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Koltovaia NA (1998) [2]
    hit Koltovaya NA (1998) [2]
    hit Enserink JM (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF2
  • YGR092W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPO11
  • YHL022C
    		•  The BioGRID Database Seperator Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Phenotypic Enhancement
    hit Rice LM (2005) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC20
  • PAC5
  • YGL116W
    		•  The BioGRID Database Seperator Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Lethality
    hit Rudner AD (2000) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS2
  • CES4
  • YML109W
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    Dosage Rescue
    hit Yu Y (1996) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC14
  • OAF3
  • YFR028C
    		•  The BioGRID Database Seperator Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    Synthetic Rescue
    bait Yuste-Rojas M (2000) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECO1
  • CTF7
  • YFR027W
    		•  The BioGRID Database Seperator Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Lethality
    bait Brands A (2008) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BNI1
  • SHE5
  • PPF3
  • YNL271C
    		•  The BioGRID Database Seperator Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Phenotypic Suppression
    hit Yu L (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC3
  • PSL1
  • YER008C
    		•  The BioGRID Database Seperator Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    Synthetic Lethality
    bait Finger FP (2000) [133]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC16
  • YKL022C
    		•  The BioGRID Database Seperator Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
    Gene Ontology: [View List]
    Biochemical Activity
    hit Rudner AD (2000) [17]
    Synthetic Lethality
    hit Rudner AD (2000) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE20
  • YHL007C
    		•  The BioGRID Database Seperator Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
    Gene Ontology: [View List]
    Biochemical Activity
    hit Wu C (1998) [1]
    Phenotypic Enhancement
    hit Eby JJ (1998) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPO21
  • SUA8
  • RPB220
  • RPB1
  • YDL140C
    		•  The BioGRID Database Seperator RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
    Gene Ontology: [View List]
    Co-localization
    hit Cosma MP (2001) [8]
    Synthetic Lethality
    bait Drebot MA (1993) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ZDS1
  • CKM1
  • CES1
  • OSS1
  • YMR273C
    		•  The BioGRID Database Seperator Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export
    Gene Ontology: [View List]
    Dosage Rescue
    hit Heo SJ (1999) [9]
    hit Yu Y (1996) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPO13
  • YHR014W
    		•  The BioGRID Database Seperator Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
    Gene Ontology: [View List]
    Dosage Rescue
    hit McCarroll RM (1994) [1]
    Phenotypic Enhancement
    hit Rice LM (2005) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDJ1
  • MAS5
  • HSP40
  • YNL064C
    		•  The BioGRID Database Seperator Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Zarzov P (1997) [5]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS1
  • RPK1
  • YDL028C
    		•  The BioGRID Database Seperator Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
    Gene Ontology: [View List]
    Dosage Lethality
    hit Rudner AD (2000) [12]
    hit Rudner AD (2000) [17]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRE11
  • XRS4
  • NGS1
  • RAD58
  • YMR224C
    		•  The BioGRID Database Seperator Subunit of a complex with Rad50p and Xrs2p (RMX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for RMX function; widely conserved
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit Grandin N (2003) [4]
    Phenotypic Enhancement
    hit Enserink JM (2009) [35]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACE2
  • YLR131C
    		•  The BioGRID Database Seperator Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKR078W
  • YKR078W
    		•  The BioGRID Database Seperator Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAC1
  • YOR178C
    		•  The BioGRID Database Seperator Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMS1
  • YOR032C
    		•  The BioGRID Database Seperator Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI2
  • YOR043W
    		•  The BioGRID Database Seperator Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
    Gene Ontology: [View List]
    Two-hybrid
    hit Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IPL1
  • PAC15
  • YPL209C
    		•  The BioGRID Database Seperator Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FMT1
  • YBL013W
    		•  The BioGRID Database Seperator Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIN2
  • YOR104W
    		•  The BioGRID Database Seperator Protein that induces appearance of [PIN+] prion when overproduced
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAV1
  • SOI3
  • YJR033C
    		•  The BioGRID Database Seperator Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTH1
  • YDR001C
    		•  The BioGRID Database Seperator Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRT2
  • HPH2
  • YAL028W
    		•  The BioGRID Database Seperator Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSB2
  • YGR014W
    		•  The BioGRID Database Seperator Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • HPR3
  • CDC17
  • CRT5
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIT1
  • ARN3
  • YEL065W
    		•  The BioGRID Database Seperator Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF4
  • TAF48
  • MPT1
  • TSG2
  • YMR005W
    		•  The BioGRID Database Seperator TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DNF2
  • YDR093W
    		•  The BioGRID Database Seperator Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS4
  • SLX2
  • YBR100W
  • YBR098W
    		•  The BioGRID Database Seperator Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination and DNA repair
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPR174C
  • YPR174C
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOX1
  • YML027W
    		•  The BioGRID Database Seperator Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAC17
  • YCL062W
  • YCL063W
    		•  The BioGRID Database Seperator Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Peng Y (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRF1
  • YDR223W
    		•  The BioGRID Database Seperator Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOP3
  • YNL042W
    		•  The BioGRID Database Seperator Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRC1
  • YML033W
  • HEH1
  • YML034W
    		•  The BioGRID Database Seperator Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYC2
  • YOR037W
    		•  The BioGRID Database Seperator Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPC54
  • YOR177C
    		•  The BioGRID Database Seperator Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAR10
  • YLR238W
    		•  The BioGRID Database Seperator Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRS2
  • HPR5
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGL4
  • STC1
  • YKR089C
    		•  The BioGRID Database Seperator Triacylglycerol lipase involved in triacylglycerol mobilization and degradation; found in lipid particles; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHS1
  • SEP7
  • YDL225W
    		•  The BioGRID Database Seperator One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
    Gene Ontology: [View List]
    Biochemical Activity
    hit Egelhofer TA (2008) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MBP1
  • YDL056W
    		•  The BioGRID Database Seperator Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
    Gene Ontology: [View List]
    Two-hybrid
    hit Manderson EN (2008) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BSP1
  • YPR171W
    		•  The BioGRID Database Seperator Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFG1
  • RAP74
  • SSU71
  • YGR186W
    		•  The BioGRID Database Seperator TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PKH2
  • YOL100W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSK1
  • YLR006C
    		•  The BioGRID Database Seperator Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KIP2
  • YPL155C
    		•  The BioGRID Database Seperator Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGL5
  • STC2
  • YOR081C
    		•  The BioGRID Database Seperator Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PXL1
  • YKR090W
    		•  The BioGRID Database Seperator LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDL089W
  • YDL089W
    		•  The BioGRID Database Seperator Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRS4
  • YDR439W
    		•  The BioGRID Database Seperator Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JSN1
  • PUF1
  • YJR091C
    		•  The BioGRID Database Seperator Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; overexpression suppresses a tub2-150 mutation and causes increased sensitivity to benomyl in wild-type cells
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD3
  • YCL012W
  • YCL014W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT6
  • SCB68
  • CIM3
  • SUG1
  • YGL048C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    Co-purification
    hit Kaiser P (1999) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYS4
  • VMA41
  • STR4
  • NHS5
  • YGR155W
    		•  The BioGRID Database Seperator Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHL050C
  • YHL050C
    		•  The BioGRID Database Seperator Putative protein of unknown function, potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU2
  • YLR045C
    		•  The BioGRID Database Seperator Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOL036W
  • YOL036W
    		•  The BioGRID Database Seperator Protein of unknown function; potential Cdc28p substrate
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ubersax JA (2003) [369]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP60
  • YAR002W
    		•