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BioGRID | Network Layout for IRA1 for Saccharomyces cerevisiae
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IRA1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: GLC1, PPD1, YBR140C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase|Ira1p; protein coding
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PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with IRA1

IRA1 was identified with 7 protein interactions and 18 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 RAS2
  • CTN5
  • CYR3
  • GLC5
  • YNL098C
    		•  The BioGRID Database Seperator GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes|Ras2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Dosage Lethality
    hit Tanaka K (1990)
    Synthetic Rescue
    bait Ruggieri R (1992)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPI1
  • YIL119C
    		•  The BioGRID Database Seperator Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation|Rpi1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Sobering AK (2002)
    Dosage Rescue
    hit Sobering AK (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRA2
  • CCS1
  • GLC4
  • YOL081W
    		•  The BioGRID Database Seperator GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin|Ira2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Tanaka K (1990)
    Phenotypic Enhancement
    hit Colombo S (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Trott A (2005)
    hit Shirayama M (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC25
  • CTN1
  • YLR310C
    		•  The BioGRID Database Seperator Cdc25p|Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Tanaka K (1989)
    Dosage Rescue
    hit Chen RA (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPB2
  • KRH1
  • YAL056W
    		•  The BioGRID Database Seperator Gpb2p|Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Harashima T (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIM11
  • GSK3
  • MDS1
  • YMR139W
    		•  The BioGRID Database Seperator Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta|Rim11p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPB1
  • KRH2
  • YOR371C
    		•  The BioGRID Database Seperator Gpb1p|Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Harashima T (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Zhao R (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CYR1
  • CDC35
  • FIL1
  • HSR1
  • YJL005W
    		•  The BioGRID Database Seperator Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation|Cyr1p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    bait Mitts MR (1991)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SML1
  • YML058W
    		•  The BioGRID Database Seperator Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase|Sml1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCH9
  • KOM1
  • YHR205W
    		•  The BioGRID Database Seperator Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB|Sch9p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Trott A (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CIN8
  • KSL2
  • SDS15
  • YEL061C
    		•  The BioGRID Database Seperator Cin8p|Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE12
  • YHR084W
    		•  The BioGRID Database Seperator Ste12p|Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Rupp S (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LTE1
  • MSI2
  • YAL024C
    		•  The BioGRID Database Seperator Lte1p|Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Shirayama M (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAS1
  • YOR101W
    		•  The BioGRID Database Seperator GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes|Ras1p; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    hit Tanaka K (1990)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSI1
  • CAC3
  • YBR195C
    		•  The BioGRID Database Seperator Msi1p|Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Ruggieri R (1989)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MUC1
  • FLO11
  • STA4
  • YIR019C
    		•  The BioGRID Database Seperator GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)|Muc1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Palecek SP (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRS6
  • MSI4
  • YOR370C
    		•  The BioGRID Database Seperator Mrs6p|Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Fujimura K (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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