| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| NAM8 |
MRE2MUD15YHR086W |
|
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
|
|
|
|
|
| SNU71 |
YGR013W |
|
Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
|
|
|
|
|
| SNU56 |
MUD10YDR240C |
|
Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
|
|
|
|
|
| PRP39 |
YML046W |
|
U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
|
|
|
|
|
| PRP40 |
YKL012W |
|
U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
|
|
|
|
|
| SNP1 |
YIL061C |
|
Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
|
|
|
|
|
| CBC2 |
MUD13CBP20SAE1YPL178W |
|
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
|
|
|
|
|
| YHC1 |
YLR298C |
|
Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
|
|
|
|
|
| PRP42 |
MUD16SNU65YDR235W |
|
U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
|
|
|
|
|
| STO1 |
CBP80GCR3CBC1YMR125W |
|
Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
|
|
|
|
|
| SMB1 |
YER029C |
|
Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'
|
|
|
|
|
| BRR1 |
YPR057W |
|
snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed
|
|
|
|
|
| SMD1 |
SPP92YGR074W |
|
Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1
|
|
|
|
|
| SMD3 |
SLT16YLR147C |
|
Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
|
|
|
|
|
| SMD2 |
YLR275W |
|
Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
|
|
|
|
|
| LUC7 |
EXM2EPE1YDL087C |
|
Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
|
|
|
|
|
| NPL3 |
MTR13MTS1NAB1YDR432W |
|
RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
|
|
|
|
|
| PTA1 |
FUN39YAL043C |
|
Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
|
|
|
|
|
| SMX2 |
SNP2YFL018W-AYFL017W-A |
|
Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
|
|
|
|
|
| TGS1 |
YPL157W |
|
Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology
|
|
|
|
|
| LEA1 |
YPL213W |
|
Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein
|
|
|
|
|
| SNU66 |
YOR308C |
|
Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; has homology to human SART-1 and to an S. pombe protein; snu66 null mutation confers cold-sensitivity but is not lethal at normal growth temperatures
|
|
|
|
|
| RIC1 |
YLR039C |
|
Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
|
|
|
|
|
| MUD2 |
YKL074C |
|
Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
|
|
|
|
|
| SWD3 |
SAF35CPS30YBR175W |
|
Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
|
|
|
|
|
| YPT6 |
YLR262C |
|
GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
|
|
|
|
|
| ELP2 |
TOT2YGR200C |
|
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
|
|
|
|
|
| MUD1 |
YBR119W |
|
U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
|
|
|
|
|
| FOB1 |
HRM1YDR110W |
|
Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
|
|
|
|
|
| FPR4 |
YLR449W |
|
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
|
|
|
|
|
| SMX3 |
YPR182W |
|
Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
|
|
|
|
|
| JJJ1 |
YNL227C |
|
Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
|
|
|
|
|
| PRP19 |
PSO4YLL036C |
|
Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases
|
|
|
|
|
| PPZ1 |
YML016C |
|
Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
|
|
|
|
|
| RRP3 |
YHR065C |
|
Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
|
|
|
|
|
| SME1 |
YOR159C |
|
Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
|
|
|
|
|
| HEK2 |
KHD1YBL032W |
|
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
|
|
|
|
|
| HEF3 |
ZRG7YNL014W |
|
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
|
|
|
|
|
| MET14 |
YKL001C |
|
Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
|
|
|
|
|
| YKR023W |
YKR023W |
|
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
|
|
|
|
|
| HHO1 |
YPL127C |
|
Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
|
|
|
|
|
| CWC27 |
YPL064C |
|
Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p
|
|
|
|
|
| YLR152C |
YLR152C |
|
Putative protein of unknown function; YLR152C is not an essential gene
|
|
|
|
|
| RPS27B |
YHR021C |
|
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
|
|
|
|
|
| NAM7 |
MOF4UPF1IFS2YMR080C |
|
ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance
|
|
|
|
|
| AGE2 |
SAT2YIL044C |
|
ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
|
|
|
|
|
| YNR004W |
YNR004W |
|
Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C
|
|
|
|
|
| SNU114 |
GIN10YKL173W |
|
GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
|
|
|
|
|
| SGD1 |
YLR336C |
|
Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia
|
|
|
|
|
| SMC6 |
RHC18YLR383W |
|
Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18
|
|
|
|
|
| MLP1 |
MPL1YKR095W |
|
Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
|
|
|
|
|
| ENO2 |
YHR174W |
|
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
|
|
|
|
|
| YEL020C |
YEL020C |
|
hypothetical protein with low sequence identity to Pdc1p
|
|
|
|
|
| TMA23 |
YMR268W-AYMR269W |
|
Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
|
|
|
|
|
| SCS7 |
FAH1YMR272C |
|
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
|
|
|
|
|
| CDC37 |
SMO1YDR168W |
|
Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
|
|
|
|
|
| PRP28 |
YDR243C |
|
RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
|
|
|
|
|
| RIM9 |
YMR063W |
|
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
|
|
|
|
|
| SIN4 |
GAL22SDI3RYE1YNL236W |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
|
|
|
|
|
| SEC22 |
TSL26SLY2YLR268W |
|
R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
|
|
|
|
|
| INO4 |
YOL108C |
|
Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
|
|
|
|
|
| MON2 |
YSL2YNL297C |
|
Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
|
|
|
|
|
| SSN2 |
SRB9NUT8MED13YDR443C |
|
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
|
|
|
|
|
| SSN3 |
NUT7GIG2CDK8YPL042C |
|
Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
|
|
|
|
|
| UME6 |
NIM2CAR80RIM16YDR207C |
|
Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
|
|
|
|
|
| NUT1 |
MED5YGL151W |
|
Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
|
|
|
|
|
| SEC28 |
ANU2YIL076W |
|
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
|
|
|
|
|
| CCS1 |
LYS7YMR038C |
|
Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
|
|
|
|
|
| SER2 |
YGR208W |
|
Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
|
|
|
|
|
| ASF1 |
CIA1YJL115W |
|
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed
|
|
|
|
|
| CAK1 |
CIV1YFL029C |
|
Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
|
|
|
|
|
| AIR2 |
YDL175C |
|
RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p
|
|
|
|
|
| DRN1 |
YGR093W |
|
Putative debranching enzyme associated ribonuclease; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
|
|
|
|
|
| YME2 |
PRP12RNA12YMR302C |
|
Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
|
|
|
|
|
| POP8 |
YBL018C |
|
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
|
|
|
|
|
| PRP11 |
RNA11YDL043C |
|
Subunit of the SF3a splicing factor complex, required for spliceosome assembly
|
|
|
|
|
| LTE1 |
MSI2YAL024C |
|
Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
|
|
|
|
|
| LSM3 |
SMX4USS2YLR438C-A |
|
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
|
|
|
|
|
| RPO21 |
SUA8RPB220RPB1YDL140C |
|
RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
|
|
|
|
|
| SYF2 |
NTC31YGR129W |
|
Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression
|
|
|
|
|
