| Name |
Aliases |
 |
Description |
|
|
| OLE1 |
MDM2YGL055W |
|
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria|Ole1p; protein coding
|
|
|
|
|
| PHO86 |
YJL117W |
|
Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles|Pho86p; protein coding
|
|
|
|
|
| SSH1 |
YBR283C |
|
Ssh1p|Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential; protein coding
|
|
|
|
|
| HXT1 |
HOR4YHR094C |
|
Hxt1p|Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; protein coding
|
|
|
|
|
| SPC1 |
YJR010C-A |
|
Spc1p|Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex; protein coding
|
|
|
|
|
| SWP1 |
YMR149W |
|
Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum|Swp1p; protein coding
|
|
|
|
|
| ERG25 |
YGR060W |
|
C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol|Erg25p; protein coding
|
|
|
|
|
| SUR2 |
SYR2YDR297W |
|
Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis|Sur2p; protein coding
|
|
|
|
|
| FCY2 |
BRA7YER056C |
|
Fcy2p|Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; protein coding
|
|
|
|
|
| TPO3 |
YPR156C |
|
Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily|Tpo3p; protein coding
|
|
|
|
|
| ILM1 |
YJR118C |
|
Ilm1p|Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth; protein coding
|
|
|
|
|
| WBP1 |
YEL002C |
|
Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum|Wbp1p; protein coding
|
|
|
|
|
| PMT5 |
YDL093W |
|
Pmt5p|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals; protein coding
|
|
|
|
|
| TSC13 |
YDL015C |
|
Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p|Tsc13p; protein coding
|
|
|
|
|
| MCH1 |
YDL054C |
|
Mch1p|Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; protein coding
|
|
|
|
|
| PHO87 |
YCR037C |
|
Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments|Pho87p; protein coding
|
|
|
|
|
| ATG22 |
AUT4YCL038C |
|
Atg22p|Protein required for the breakdown of autophagic vesicles in the vacuole during autophagy, putative integral membrane protein that localizes to vacuolar membranes and punctate structures attached to the vacuole; protein coding
|
|
|
|
|
| AGP1 |
YCC5YCL025C |
|
Agp1p|Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); protein coding
|
|
|
|
|
| FEN2 |
YCR028C |
|
Fen2p|Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; protein coding
|
|
|
|
|
| VCX1 |
HUM1MNR1YDL128W |
|
Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter|Vcx1p; protein coding
|
|
|
|
|
| YCR061W |
YCR062W |
|
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern|Ycr061wp; protein coding
|
|
|
|
|
| GIT1 |
YCR098C |
|
Git1p|Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; protein coding
|
|
|
|
|
| HXT7 |
YDR342C |
|
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels|Hxt7p; protein coding
|
|
|
|
|
| CAN1 |
YEL063C |
|
Can1p|Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; protein coding
|
|
|
|
|
| CUP5 |
CLS7GEF2VMA3YEL027W |
|
Cup5p|Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis; protein coding
|
|
|
|
|
| HVG1 |
YEM9YER039C |
|
Hvg1p|Protein of unknown function, has homology to Vrg4p; protein coding
|
|
|
|
|
| ARR3 |
ACR3YPR201W |
|
Arr3p|Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; protein coding
|
|
|
|
|
| BST1 |
PER17YFL025C |
|
Bst1p|GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; protein coding
|
|
|
|
|
| PMP2 |
YEL017C-A |
|
Pmp2p|Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1; protein coding
|
|
|
|
|
| GNP1 |
YDR508C |
|
Gnp1p|High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; protein coding
|
|
|
|
|
| GPI8 |
YDR331W |
|
ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog|Gpi8p; protein coding
|
|
|
|
|
| YDR307W |
YDR307W |
|
Putative protein of unknown function|Ydr307wp; protein coding
|
|
|
|
|
| MAL31 |
YBR298C |
|
Mal31p|Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C; protein coding
|
|
|
|
|
| ERD1 |
LDB2YDR414C |
|
Erd1p|Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p); protein coding
|
|
|
|
|
| NHX1 |
NHA2VPS44VPL27YDR456W |
|
Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock|Nhx1p; protein coding
|
|
|
|
|
| BAP3 |
PAP1YDR046C |
|
Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine|Bap3p; protein coding
|
|
|
|
|
| YBR287W |
YBR287W |
|
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene|Ybr287wp; protein coding
|
|
|
|
|
| SCS7 |
FAH1YMR272C |
|
Scs7p|Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; protein coding
|
|
|
|
|
| SPC2 |
SPY1YML055W |
|
Spc2p|Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; protein coding
|
|
|
|
|
| SHR3 |
APF1YDL212W |
|
Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface|Shr3p; protein coding
|
|
|
|
|
| ORM2 |
YLR350W |
|
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum|Orm2p; protein coding
|
|
|
