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BioGRID | Network Layout for AKL1 for Saccharomyces cerevisiae
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AKL1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YBR059C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Akl1p|Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with AKL1

AKL1 was identified with 58 protein interactions and 2 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SKI8
  • REC103
  • YGL213C
    		•  The BioGRID Database Seperator Protein involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs as well as double-strand break formation during meiotic recombination; required for repressing propagation of dsRNA viruses|Ski8p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Two-hybrid
    bait/hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCD5
  • FTB1
  • YOR329C
    		•  The BioGRID Database Seperator Protein required for normal cortical actin organization and endocytosis; multicopy suppressor of clathrin deficiency; acts as a targeting subunit for protein phosphatase type 1|Scd5p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    Synthetic Rescue
    bait Henry KR (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADE5,7
  • YGL234W
    		•  The BioGRID Database Seperator Ade5,7p|Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAD1
  • YMR250W
    		•  The BioGRID Database Seperator Gad1p|Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP49
  • NSP49
  • YGL172W
    		•  The BioGRID Database Seperator Nup49p|Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJL084C
  • ALY2
    		•  The BioGRID Database Seperator Aly2p|Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC2
  • YNL272C
    		•  The BioGRID Database Seperator Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport|Sec2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR239C
  • YDR239C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes, based on co-purification experiments|Ydr239cp; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE9
  • YGR135W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; the only nonessential 20S subunit|Pre9p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRC1
  • LBC1
  • YMR297W
    		•  The BioGRID Database Seperator Prc1p|Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABP140
  • YOR240W
  • YOR239W
    		•  The BioGRID Database Seperator Abp140p|Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC31
  • DSK1
  • YOR257W
    		•  The BioGRID Database Seperator Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; interacts with Kar1p|Cdc31p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRE1
  • YPL223C
    		•  The BioGRID Database Seperator Gre1p|Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET2
  • YNL277W
    		•  The BioGRID Database Seperator L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway|Met2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT16
  • CDC68
  • SSF1
  • YGL207W
    		•  The BioGRID Database Seperator Spt16p|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRZ1
  • HAL8
  • TCN1
  • YNL027W
    		•  The BioGRID Database Seperator Crz1p|Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK2
  • PKA2
  • PKA3
  • YKR1
  • YPL203W
    		•  The BioGRID Database Seperator Tpk2p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait/hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PTK2
  • STK2
  • YJR059W
    		•  The BioGRID Database Seperator Ptk2p|Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK3
  • YKL166C
    		•  The BioGRID Database Seperator Tpk3p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VHS1
  • YDR247W
    		•  The BioGRID Database Seperator Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p|Vhs1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGL059W
  • YGL059W
    		•  The BioGRID Database Seperator Protein kinase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies|Ygl059wp; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YIL091C
  • YIL091C
    		•  The BioGRID Database Seperator Protein required for cell viability|Yil091cp; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FOX2
  • POX2
  • YKR009C
    		•  The BioGRID Database Seperator Fox2p|Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR021W
  • YGR021W
    		•  The BioGRID Database Seperator Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies|Ygr021wp; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FSH2
  • YMR222C
    		•  The BioGRID Database Seperator Fsh2p|Serine hydrolase that localizes to the cytoplasm; sequence is similar to Fsh1p and Fsh3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP9
  • YLR276C
    		•  The BioGRID Database Seperator ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit|Dbp9p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MIP6
  • YHR015W
    		•  The BioGRID Database Seperator Mip6p|Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSB3
  • YFR024C
  • YFR024C-A
    		•  The BioGRID Database Seperator Lsb3p|Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JJJ1
  • YNL227C
    		•  The BioGRID Database Seperator Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis|Jjj1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEX14
  • YGL153W
    		•  The BioGRID Database Seperator Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p|Pex14p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP15
  • YMR304W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that may play a role in ubiquitin precursor processing|Ubp15p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DPS1
  • YLL018C
    		•  The BioGRID Database Seperator Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation|Dps1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFK1
  • YGR240C
    		•  The BioGRID Database Seperator Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes|Pfk1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSF2
  • YDR312W
    		•  The BioGRID Database Seperator Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family|Ssf2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HST1
  • YOL068C
    		•  The BioGRID Database Seperator Hst1p|NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL40A
  • UB11
  • UBI1
  • YIL148W
    		•  The BioGRID Database Seperator Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes|Rpl40ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AKL1
  • YBR059C
    		•  The BioGRID Database Seperator Akl1p|Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRK1
  • PAK1
  • YIL095W
    		•  The BioGRID Database Seperator Prk1p|Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRM9
  • YML014W
    		•  The BioGRID Database Seperator Trm9p|tRNA methyltransferase, catalyzes the esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); may have a role in stress response; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Ito T (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP5
  • YER144C
    		•  The BioGRID Database Seperator Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck|Ubp5p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling|Bmh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG18
  • AUT10
  • CVT18
  • NMR1
  • YFR021W
    		•  The BioGRID Database Seperator Atg18p|Phosphatidylinositol 3,5-bisphosphate-binding protein of the vacuolar membrane, predicted to fold as a seven-bladed beta-propeller; required for recycling of Atg9p through the pre-autophagosomal structure; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRP40
  • YKR092C
    		•  The BioGRID Database Seperator Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140|Srp40p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NSR1
  • SHE5
  • YGR159C
    		•  The BioGRID Database Seperator Nsr1p|Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator