| Name |
Aliases |
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Description |
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| SSA1 |
YG100YAL005C |
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ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
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| CEG1 |
YGL130W |
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Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide|Ceg1p; protein coding
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| CLP1 |
YOR250C |
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Clp1p|Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation; protein coding
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| YDJ1 |
HSP40MAS5YNL064C |
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Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family|Ydj1p; protein coding
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| HSP82 |
HSP90YPL240C |
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Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
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| SSA2 |
YG102YLL024C |
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ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall|Ssa2p; protein coding
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| SIS2 |
HAL3YKR072C |
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Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression|Sis2p; protein coding
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| GTT2 |
YLL060C |
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Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p|Gtt2p; protein coding
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| RAD23 |
YEL037C |
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Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins|Rad23p; protein coding
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| YDR128W |
YDR128W |
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Putative protein of unknown function|Ydr128wp; protein coding
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| HEM13 |
YDR044W |
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Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)|Hem13p; protein coding
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| MMS22 |
SLM2YLR320W |
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Mms22p|Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; protein coding
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| UTP6 |
YDR449C |
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Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA|Utp6p; protein coding
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| RPL38 |
YLR325C |
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Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein|Rpl38p; protein coding
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| RAD50 |
YNL250W |
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Rad50p|Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; protein coding
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| MSB3 |
GYP3YNL293W |
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GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth|Msb3p; protein coding
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| YKL088W |
YKL088W |
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Predicted phosphopantothenoylcysteine decarboxylase, may be involved in coenzyme A biosynthesis; interacts with Sis2p and Vhs3p|Ykl088wp; protein coding
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| PKR1 |
YMR123W |
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Pkr1p|V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin; protein coding
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| IDI1 |
BOT2LPH10YPL117C |
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Idi1p|Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; protein coding
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| PMT1 |
YDL095W |
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Pmt1p|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals; protein coding
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| YLR345W |
YLR345W |
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Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene|Ylr345wp; protein coding
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| ENP1 |
MEG1YBR247C |
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Enp1p|Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; protein coding
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| STE11 |
YLR362W |
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Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p|Ste11p; protein coding
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| STI1 |
YOR027W |
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Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein|Sti1p; protein coding
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| YCR043C |
YCR043C |
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Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene|Ycr043cp; protein coding
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| SED5 |
YLR026C |
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Sed5p|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins; protein coding
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| BET1 |
SLY12YIL004C |
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Bet1p|Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; protein coding
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| CLB2 |
YPR119W |
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B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome|Clb2p; protein coding
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| LAS17 |
BEE1YOR181W |
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Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)|Las17p; protein coding
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| SRB4 |
MED17YER022W |
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Srb4p|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein coding
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| CPR7 |
YJR032W |
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Cpr7p|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein coding
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| NAF1 |
YNL124W |
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Naf1p|Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins; protein coding
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| SCEI |
Q0160 |
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I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene|Sceip; protein coding
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| SRB5 |
MED18YGR104C |
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Srb5p|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance; protein coding
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| IES2 |
YNL215W |
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Ies2p|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; protein coding
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| CDC25 |
CTN1YLR310C |
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Cdc25p|Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; protein coding
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| SSN3 |
CDK8GIG2NUT7YPL042C |
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Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression|Ssn3p; protein coding
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| SSN8 |
GIG3NUT9RYE2YNL025C |
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Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance|Ssn8p; protein coding
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| SRP1 |
KAP60SCM1YNL189W |
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Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation|Srp1p; protein coding
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| SSA4 |
YG107YER103W |
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Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation|Ssa4p; protein coding
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| NUP82 |
HRB187YJL061W |
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Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC|Nup82p; protein coding
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