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BioGRID | Network Layout for SMT3 for Saccharomyces cerevisiae
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SMT3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YDR510W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SMT3

SMT3 was identified with 338 protein interactions and 11 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 HEX3
  • SLX5
  • YDL013W
    		•  The BioGRID Database Seperator Slx5p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    hit Hannich JT (2005)
    bait/hit Ii T (2007)
    hit Uzunova K (2007)
    Biochemical Activity
    bait Xie Y (2007)
    Affinity Capture-Western
    hit Uzunova K (2007)
    Synthetic Growth Defect
    hit Uzunova K (2007)
    bait Wang Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC9
  • YDL064W
    		•  The BioGRID Database Seperator SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)|Ubc9p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Uetz P (2000)
    Affinity Capture-Western
    hit Johnson ES (1997)
    Reconstituted Complex
    bait Bencsath KP (2002)
    hit Schwarz SE (1998)
    Co-crystal Structure
    hit Duda DM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBA2
  • UAL1
  • YDR390C
    		•  The BioGRID Database Seperator Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability|Uba2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Johnson ES (1997)
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    Reconstituted Complex
    hit Johnson ES (1997)
    Synthetic Rescue
    bait Schwienhorst I (2000)
    Dosage Growth Defect
    bait Schwienhorst I (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HPR5
  • SRS2
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination|Srs2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    hit Hannich JT (2005)
    bait Pfander B (2005)
    Affinity Capture-MS
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIS1
  • DIS1
  • YOR191W
    		•  The BioGRID Database Seperator Member of the SWI/SNF family of DNA-dependent ATPases, plays a role in antagonizing silencing during mating-type switching, contains an N-terminal domain that interacts with Sir4p and a C-terminal SNF2 domain|Ris1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hannich JT (2005)
    hit Uzunova K (2007)
    Affinity Capture-MS
    hit Hannich JT (2005)
    Affinity Capture-Western
    hit Uzunova K (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC3
  • YLR314C
    		•  The BioGRID Database Seperator Cdc3p|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Takahashi Y (1999)
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    Biochemical Activity
    bait Johnson ES (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOP2
  • TOR3
  • TRF3
  • YNL088W
    		•  The BioGRID Database Seperator Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis|Top2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Bachant J (2002)
    Affinity Capture-MS
    hit Hannich JT (2005)
    Co-localization
    bait Takahashi Y (2006)
    Biochemical Activity
    hit Takahashi Y (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIR1
  • PIP1
  • YER032W
    		•  The BioGRID Database Seperator Fir1p|Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hannich JT (2005)
    hit Uzunova K (2007)
    Affinity Capture-MS
    hit Hannich JT (2005)
    Affinity Capture-Western
    hit Uzunova K (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIZ1
  • ULL1
  • YDR409W
    		•  The BioGRID Database Seperator SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring|Siz1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Takahashi Y (2001)
    hit Uzunova K (2007)
    Reconstituted Complex
    hit Takahashi Y (2005)
    Affinity Capture-Western
    hit Uzunova K (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AOS1
  • RHC31
  • YPR180W
    		•  The BioGRID Database Seperator Aos1p|Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Johnson ES (1997)
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    Reconstituted Complex
    hit Johnson ES (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHS1
  • SEP7
  • YDL225W
    		•  The BioGRID Database Seperator One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis|Shs1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    Biochemical Activity
    bait Johnson ES (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIS1
  • JIP1
  • YNL078W
    		•  The BioGRID Database Seperator Nis1p|Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hannich JT (2005)
    hit Uzunova K (2007)
    Affinity Capture-Western
    hit Uzunova K (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC11
  • PSL9
  • YJR076C
    		•  The BioGRID Database Seperator Cdc11p|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    Biochemical Activity
    bait Johnson ES (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL30
  • YBR088C
    		•  The BioGRID Database Seperator Pol30p|Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    Affinity Capture-Western
    bait Windecker H (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CBF2
  • CEP2
  • CSL5
  • CTF14
  • YGR140W
    		•  The BioGRID Database Seperator Cbf2p|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Montpetit B (2006)
    Biochemical Activity
    hit Montpetit B (2006)
    Affinity Capture-Western
    bait Montpetit B (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX8
  • YER116C
    		•  The BioGRID Database Seperator Slx8p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Ii T (2007)
    Biochemical Activity
    bait Xie Y (2007)
    Synthetic Growth Defect
    bait Wang Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NFI1
  • SIZ2
  • YOR156C
    		•  The BioGRID Database Seperator Nfi1p|SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Takahashi Y (2003)
    hit Hannich JT (2005)
    Synthetic Growth Defect
    bait Wang Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOP3
  • YNL042W
    		•  The BioGRID Database Seperator Bop3p|Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUB2
  • YDL084W
    		•  The BioGRID Database Seperator Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56|Sub2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FBA1
  • LOT1
  • YKL060C
    		•  The BioGRID Database Seperator Fba1p|Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP1
  • YER047C
    		•  The BioGRID Database Seperator Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system|Sap1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hannich JT (2005)
    Affinity Capture-MS
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Hannich JT (2005)
    Affinity Capture-MS
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSA1
  • MPG1
  • SRB1
  • VIG9
  • YDL055C
    		•  The BioGRID Database Seperator GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure|Psa1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    Two-hybrid
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STB3
  • YDR169C
    		•  The BioGRID Database Seperator Protein that binds Sin3p in a two-hybrid assay|Stb3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CET1
  • CES5
  • YPL228W
    		•  The BioGRID Database Seperator Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide|Cet1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TDH3
  • GLD1
  • HSP35
  • HSP36
  • YGR192C
    		•  The BioGRID Database Seperator Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall|Tdh3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC48
  • YDL126C
    		•  The BioGRID Database Seperator ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome|Cdc48p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDC1
  • YLR044C
    		•  The BioGRID Database Seperator Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism|Pdc1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    hit Hannich JT (2005)
    The BioGRID Database Seperator