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BioGRID | Network Layout for SDC1 for Saccharomyces cerevisiae
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SDC1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: CPS25, SAF19, YDR469W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Sdc1p|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SDC1

SDC1 was identified with 40 protein interactions and 136 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 BRE2
  • CPS60
  • YLR015W
    		•  The BioGRID Database Seperator Bre2p|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; involved in telomere maintenance; similar to trithorax-group protein ASH2L; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001)
    bait Uetz P (2000)
    bait/hit Dehe PM (2006)
    Affinity Capture-MS
    bait/hit Roguev A (2001)
    bait Miller T (2001)
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    bait Lee JS (2007)
    bait Nedea E (2008)
    Affinity Capture-Western
    bait Lee JS (2007)
    Phenotypic Enhancement
    bait Mueller JE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET1
  • YTX1
  • YHR119W
    		•  The BioGRID Database Seperator Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain|Set1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Roguev A (2001)
    bait Miller T (2001)
    hit Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    bait Dehe PM (2006)
    Affinity Capture-Western
    bait Nagy PL (2002)
    Co-purification
    bait Miller T (2001)
    bait Nagy PL (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD1
  • CPS50
  • FUN16
  • SAF49
  • YAR003W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7|Swd1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait/hit Roguev A (2001)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPP1
  • CPS40
  • SAF41
  • YPL138C
    		•  The BioGRID Database Seperator Spp1p|Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Roguev A (2001)
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    Phenotypic Enhancement
    bait Mueller JE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHG1
  • CPS15
  • YBR258C
    		•  The BioGRID Database Seperator Shg1p|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Roguev A (2001)
    hit Krogan NJ (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD3
  • CPS30
  • SAF35
  • YBR175W
    		•  The BioGRID Database Seperator Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5|Swd3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Roguev A (2001)
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWD2
  • CPS35
  • SAF37
  • YKL018W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination|Swd2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SET2
  • EZL1
  • YJL168C
    		•  The BioGRID Database Seperator Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p|Set2p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Krogan NJ (2003)
    Synthetic Lethality
    bait Krogan NJ (2003)
    bait Krogan NJ (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin|Htz1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Krogan NJ (2004)
    Phenotypic Enhancement
    bait Collins SR (2007)
    Synthetic Growth Defect
    bait Venkatasubrahmanyam S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • BUR5
  • SIN2
  • YBR010W
    		•  The BioGRID Database Seperator Hht1p|One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Mueller JE (2006)
    Synthetic Growth Defect
    hit Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Arp6p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Krogan NJ (2004)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting|Vps71p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Krogan NJ (2004)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swc5p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Krogan NJ (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN6
  • NAS4
  • YDL097C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion|Rpn6p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    Synthetic Lethality
    hit Laribee RN (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae|Swc3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Krogan NJ (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT109
  • KIM2
  • REM50
  • YLL002W
    		•  The BioGRID Database Seperator Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition|Rtt109p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    Synthetic Lethality
    bait Jessulat M (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMD7
  • HUR2
  • GET2
  • YER083C
    		•  The BioGRID Database Seperator Get2p|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN4
  • SON1
  • UFD5
  • YDL020C
    		•  The BioGRID Database Seperator Rpn4p|Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    Synthetic Lethality
    hit Laribee RN (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Spt3p|Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ingvarsdottir K (2005)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID21
  • EAF1
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex|Eaf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Krogan NJ (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A|Swr1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Krogan NJ (2004)
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IMD3
  • YLR432W
    		•  The BioGRID Database Seperator Imd3p|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT2
  • YNL031C
    		•  The BioGRID Database Seperator Hht2p|One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Mueller JE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA22
  • CEV1
  • VPH6
  • YHR060W
    		•  The BioGRID Database Seperator Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)|Vma22p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SDC1
  • CPS25
  • SAF19
  • YDR469W
    		•  The BioGRID Database Seperator Sdc1p|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Dehe PM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ISC1
  • YER019W
    		•  The BioGRID Database Seperator Isc1p|Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NEW1
  • YPL226W
    		•  The BioGRID Database Seperator ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein|New1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HPR5
  • SRS2
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination|Srs2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC1
  • RSD1
  • YKL212W
    		•  The BioGRID Database Seperator Lipid phosphoinositide phosphatase of the ER and Golgi, involved in protein trafficking and secretion|Sac1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC9
  • MMS8
  • YDL164C
    		•  The BioGRID Database Seperator Cdc9p|DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPB3
  • YIL021W
    		•  The BioGRID Database Seperator RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit|Rpb3p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator Doa1p|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKS1
  • YBR135W
    		•  The BioGRID Database Seperator Cks1p|Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA49
  • YNL248C
    		•  The BioGRID Database Seperator RNA polymerase I subunit A49|Rpa49p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IRA2
  • CCS1
  • GLC4
  • YOL081W
    		•  The BioGRID Database Seperator GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin|Ira2p; protein coding
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator