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BioGRID | Network Layout for NHX1 for Saccharomyces cerevisiae
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NHX1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: NHA2, VPS44, VPL27, YDR456W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock|Nhx1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 6 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with NHX1

NHX1 was identified with 20 protein interactions and 24 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 GYP6
  • YJL044C
    		•  The BioGRID Database Seperator GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport|Gyp6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ali R (2004)
    Two-hybrid
    bait Ali R (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIA2
  • YOR29-31
  • YOR080W
    		•  The BioGRID Database Seperator Dia2p|Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    Synthetic Lethality
    bait Blake D (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KHA1
  • YJL094C
    		•  The BioGRID Database Seperator Kha1p|Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Maresova L (2005)
    Dosage Rescue
    hit Maresova L (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FTR1
  • YER145C
    		•  The BioGRID Database Seperator Ftr1p|High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMA1
  • YGL008C
    		•  The BioGRID Database Seperator Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases|Pma1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERS1
  • YCR075C
    		•  The BioGRID Database Seperator Ers1p|Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPI8
  • YDR331W
    		•  The BioGRID Database Seperator ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog|Gpi8p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHX1
  • NHA2
  • VPS44
  • VPL27
  • YDR456W
    		•  The BioGRID Database Seperator Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock|Nhx1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPI1
  • YGR216C
    		•  The BioGRID Database Seperator Gpi1p|Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO88
  • YBR106W
    		•  The BioGRID Database Seperator Pho88p|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FEN1
  • ELO2
  • GNS1
  • VBM2
  • YCR034W
    		•  The BioGRID Database Seperator Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway|Fen1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAT5
  • COQ7
  • YOR125C
    		•  The BioGRID Database Seperator Cat5p|Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSM4
  • DOA10
  • KIS3
  • YIL030C
    		•  The BioGRID Database Seperator Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRL1
  • YPR079W
    		•  The BioGRID Database Seperator Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases|Mrl1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHL042W
  • YHL042W
    		•  The BioGRID Database Seperator Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins|Yhl042wp; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIO5
  • YNR056C
    		•  The BioGRID Database Seperator Bio5p|Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSU1
  • LPG16
  • YPL092W
    		•  The BioGRID Database Seperator Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein|Ssu1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRK2
  • RPD2
  • YKR050W
    		•  The BioGRID Database Seperator Component of the Trk1p-Trk2p potassium transport system|Trk2p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC11
  • YIR022W
    		•  The BioGRID Database Seperator 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum|Sec11p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT12
  • YIL171W
    		•  The BioGRID Database Seperator pseudo
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUR4
  • APA1
  • ELO3
  • SRE1
  • YLR372W
    		•  The BioGRID Database Seperator Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis|Sur4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL321W
  • VNX1
    		•  The BioGRID Database Seperator Low affinity vacuolar membrane localized monovalent cation/H+ antiporter; member of the calcium exchanger (CAX) family; potential Cdc28p substrate|Vnx1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Cagnac O (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ENA1
  • HOR6
  • PMR2
  • YDR040C
    		•  The BioGRID Database Seperator Ena1p|P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Cagnac O (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP4
  • ACT3
  • YJL081C
    		•  The BioGRID Database Seperator Arp4p|Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VID21
  • EAF1
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex|Eaf1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMD7
  • HUR2
  • GET2
  • YER083C
    		•  The BioGRID Database Seperator Get2p|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Esa1p|Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EPL1
  • YFL024C
    		•  The BioGRID Database Seperator Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb|Epl1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC20
  • PAC5
  • YGL116W
    		•  The BioGRID Database Seperator Cdc20p|Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Lin YY (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Ali R (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCR4
  • FUN27
  • NUT21
  • YAL021C
    		•  The BioGRID Database Seperator Ccr4p|Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NHA1
  • YLR138W
    		•  The BioGRID Database Seperator Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH|Nha1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Brett CL (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO85
  • LDB15
  • YPL031C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5|Pho85p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Huang D (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF4
  • CHL15
  • POB1
  • YPR135W
    		•  The BioGRID Database Seperator Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion|Ctf4p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM39
  • GET1
  • YGL020C
    		•  The BioGRID Database Seperator Get1p|Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD27
  • ERC11
  • RTH1
  • FEN1
  • YKL113C
    		•  The BioGRID Database Seperator 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family|Rad27p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP2
  • CAF1
  • YNR052C
    		•  The BioGRID Database Seperator Pop2p|RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS22
  • SLM2
  • YLR320W
    		•  The BioGRID Database Seperator Mms22p|Protein involved in resistance to ionizing radiation; acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • LSD1
  • MEC2
  • SPK1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication|Rad53p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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