| Name |
Aliases |
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Description |
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| RPN5 |
NAS5YDL147W |
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Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p|Rpn5p; protein coding
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| RPN6 |
NAS4YDL097C |
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Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion|Rpn6p; protein coding
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| RPN8 |
YOR261C |
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Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p|Rpn8p; protein coding
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| RPN10 |
MCB1SUN1YHR200W |
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Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
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| RPT1 |
CIM5YTA3YKL145W |
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One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
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| RPN1 |
HRD2NAS1YHR027C |
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Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions|Rpn1p; protein coding
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| RPN11 |
MPR1YFR004W |
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Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates|Rpn11p; protein coding
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| RPT3 |
YNT1YTA2YDR394W |
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One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B|Rpt3p; protein coding
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| UBP6 |
YFR010W |
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Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds|Ubp6p; protein coding
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| RPT6 |
CIM3CRL3SCB68YGL048C |
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One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle|Rpt6p; protein coding
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| SEM1 |
DSS1HOD1YDR363W-A |
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Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1|Sem1p; protein coding
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| RPN12 |
NIN1YFR052W |
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Rpn12p|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein coding
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| RPN3 |
SUN2YER021W |
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Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control|Rpn3p; protein coding
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| RPN7 |
YPR108W |
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Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits|Rpn7p; protein coding
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| RPT4 |
CRL13PCS1SUG2YOR259C |
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One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle|Rpt4p; protein coding
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| RPT2 |
YHS4YTA5YDL007W |
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One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle|Rpt2p; protein coding
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| RPN2 |
SEN3YIL075C |
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Rpn2p|Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p; protein coding
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| RPT5 |
YTA1YOR117W |
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One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription|Rpt5p; protein coding
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| NAS6 |
YGR232W |
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Nas6p|Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6; protein coding
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| RPN13 |
YLR421C |
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Rpn13p|Subunit of the 19S regulatory particle of the 26S proteasome lid; protein coding
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| RAD23 |
YEL037C |
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Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins|Rad23p; protein coding
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| SPG5 |
YMR191W |
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Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources|Spg5p; protein coding
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| ECM29 |
YHL030W |
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Ecm29p|Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome; protein coding
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| ARO1 |
YDR127W |
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Aro1p|Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; protein coding
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| PRE5 |
YMR314W |
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20S proteasome alpha-type subunit|Pre5p; protein coding
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| TUB3 |
YML124C |
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Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p|Tub3p; protein coding
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| PRE6 |
YOL038W |
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20S proteasome alpha-type subunit; green fluorescent protein (GFP)-fusion protein relocates from the cytosol to the mitochondrial outer surface upon oxidative stress|Pre6p; protein coding
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| POL4 |
YCR014C |
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DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta|Pol4p; protein coding
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| MAE1 |
YKL029C |
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Mae1p|Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids; protein coding
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| DED81 |
YHR019C |
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Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA|Ded81p; protein coding
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| TIP41 |
YPR040W |
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Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway|Tip41p; protein coding
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| KAP122 |
PDR6YGL016W |
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Kap122p|Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance; protein coding
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| RRS1 |
YOR294W |
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Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice|Rrs1p; protein coding
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| NPT1 |
YOR209C |
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Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus|Npt1p; protein coding
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| TAT1 |
VAP1TAP1YBR069C |
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