The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for RPT3 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

RPT3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YNT1, YTA2, YDR394W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B|Rpt3p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with RPT3

RPT3 was identified with 161 protein interactions and 2 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 RPT5
  • YTA1
  • YOR117W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription|Rpt5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    hit Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    bait/hit Uetz P (2000)
    bait/hit Fu H (2001)
    bait/hit Cagney G (2001)
    Co-purification
    hit Rubin DM (1998)
    Co-fractionation
    hit Takeuchi J (2004)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAS6
  • YGR232W
    		•  The BioGRID Database Seperator Nas6p|Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    bait/hit Uetz P (2000)
    Co-crystal Structure
    bait Nakamura Y (2007)
    bait Nakamura Y (2007)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Gavin AC (2002)
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    bait Seong KM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN1
  • HRD2
  • NAS1
  • YHR027C
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions|Rpn1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Co-purification
    bait Glickman MH (1998)
    bait Glickman MH (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • CIM5
  • YTA3
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Ho Y (2002)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Co-purification
    hit Rubin DM (1998)
    Co-fractionation
    hit Takeuchi J (2004)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT4
  • CRL13
  • PCS1
  • SUG2
  • YOR259C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle|Rpt4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    hit Collins SR (2007)
    Two-hybrid
    bait/hit Uetz P (2000)
    bait/hit Cagney G (2001)
    Co-purification
    hit Rubin DM (1998)
    Co-fractionation
    hit Takeuchi J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT6
  • CIM3
  • CRL3
  • SCB68
  • YGL048C
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle|Rpt6p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Fu H (2001)
    bait/hit Cagney G (2001)
    Co-fractionation
    hit Takeuchi J (2004)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP6
  • YFR010W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds|Ubp6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Gavin AC (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN9
  • YDR427W
    		•  The BioGRID Database Seperator Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects|Rpn9p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Two-hybrid
    bait/hit Cagney G (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN6
  • NAS4
  • YDL097C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion|Rpn6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT2
  • YHS4
  • YTA5
  • YDL007W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle|Rpt2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    Co-purification
    hit Rubin DM (1998)
    Co-fractionation
    hit Takeuchi J (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN11
  • MPR1
  • YFR004W
    		•  The BioGRID Database Seperator Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates|Rpn11p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN5
  • NAS5
  • YDL147W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p|Rpn5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN12
  • NIN1
  • YFR052W
    		•  The BioGRID Database Seperator Rpn12p|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Ho Y (2002)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23
  • YEL037C
    		•  The BioGRID Database Seperator Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins|Rad23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Krogan NJ (2006)
    Affinity Capture-Western
    bait Ishii T (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN3
  • SUN2
  • YER021W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control|Rpn3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    hit Collins SR (2007)
    Co-purification
    hit Rubin DM (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN7
  • YPR108W
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits|Rpn7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT3
  • YNT1
  • YTA2
  • YDR394W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B|Rpt3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Uetz P (2000)
    bait/hit Fu H (2001)
    bait/hit Cagney G (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN8
  • YOR261C
    		•  The BioGRID Database Seperator Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p|Rpn8p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1|Sem1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Sone T (2004)
    bait Krogan NJ (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CPA2
  • YJR109C
    		•  The BioGRID Database Seperator Cpa2p|Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN2
  • SEN3
  • YIL075C
    		•  The BioGRID Database Seperator Rpn2p|Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AME1
  • ARP100
  • YBR211C
    		•  The BioGRID Database Seperator Ame1p|Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Uetz P (2000)
    bait/hit Cagney G (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE1
  • YER012W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle|Pre1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Verma R (2000)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM29
  • YHL030W
    		•  The BioGRID Database Seperator Ecm29p|Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URA7
  • YBL039C
    		•  The BioGRID Database Seperator Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis|Ura7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD3
  • REM1
  • YER171W
    		•  The BioGRID Database Seperator 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein|Rad3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE6
  • YOL038W
    		•  The BioGRID Database Seperator 20S proteasome alpha-type subunit; green fluorescent protein (GFP)-fusion protein relocates from the cytosol to the mitochondrial outer surface upon oxidative stress|Pre6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN13
  • YLR421C
    		•  The BioGRID Database Seperator Rpn13p|Subunit of the 19S regulatory particle of the 26S proteasome lid; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Rad51p|Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Rad50p|Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YME1
  • OSD1
  • YTA11
  • YPR024W
    		•