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BioGRID | Network Layout for UBA2 for Saccharomyces cerevisiae
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UBA2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: UAL1, YDR390C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability|Uba2p; protein coding
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PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 4 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with UBA2

UBA2 was identified with 13 protein interactions and 11 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 AOS1
  • RHC31
  • YPR180W
    		•  The BioGRID Database Seperator Aos1p|Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    hit Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Reconstituted Complex
    hit Johnson ES (1997)
    Dosage Rescue
    hit Schwienhorst I (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Johnson ES (1997)
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    Reconstituted Complex
    bait Johnson ES (1997)
    Synthetic Rescue
    hit Schwienhorst I (2000)
    Dosage Growth Defect
    hit Schwienhorst I (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAP1
  • YKR002W
    		•  The BioGRID Database Seperator Pap1p|Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait del Olmo M (1997)
    Two-hybrid
    bait del Olmo M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBC9
  • YDL064W
    		•  The BioGRID Database Seperator SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)|Ubc9p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Knipscheer P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit del Olmo M (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBA2
  • UAL1
  • YDR390C
    		•  The BioGRID Database Seperator Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability|Uba2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Dohmen RJ (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX8
  • YER116C
    		•  The BioGRID Database Seperator Slx8p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Wang Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEX3
  • SLX5
  • YDL013W
    		•  The BioGRID Database Seperator Slx5p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Wang Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NFI1
  • SIZ2
  • YOR156C
    		•  The BioGRID Database Seperator Nfi1p|SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Wang Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ULP2
  • SMT4
  • YIL031W
    		•  The BioGRID Database Seperator Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate|Ulp2p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Schwienhorst I (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CBF2
  • CEP2
  • CSL5
  • CTF14
  • YGR140W
    		•  The BioGRID Database Seperator Cbf2p|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Winkler AA (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSK1
  • FUN31
  • YAL017W
    		•  The BioGRID Database Seperator One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status|Psk1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Rutter J (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSK2
  • YOL045W
    		•  The BioGRID Database Seperator One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)|Psk2p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Rutter J (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MOT1
  • BUR3
  • LPF4
  • YPL082C
    		•  The BioGRID Database Seperator Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity|Mot1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Wang Z (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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