The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for CDC40 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

CDC40

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: PRP17, SLT15, SLU4, YDR364C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Cdc40p|Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 13 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CDC40

CDC40 was identified with 29 protein interactions and 77 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 PRP16
  • YKR086W
    		•  The BioGRID Database Seperator Prp16p|RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activity; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    bait Xu D (1998)
    bait Jones MH (1995)
    hit Ben-Yehuda S (2000)
    hit Seshadri V (1996)
    hit Frank D (1992)
    hit Mnaimneh S (2004)
    Dosage Rescue
    hit Jones MH (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CWC2
  • NTC40
  • YDL209C
    		•  The BioGRID Database Seperator Cwc2p|Protein involved in pre-mRNA splicing, component of a complex containing Cef1p; interacts with Prp19p; contains an RNA recognition motif; has similarity to S. pombe Cwf2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Hazbun TR (2003)
    bait Ohi MD (2002)
    bait Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP19
  • PSO4
  • YLL036C
    		•  The BioGRID Database Seperator Prp19p|Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait Ohi MD (2002)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP45
  • FUN20
  • YAL032C
    		•  The BioGRID Database Seperator Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene|Prp45p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEF1
  • NTC85
  • YMR213W
    		•  The BioGRID Database Seperator Cef1p|Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Ohi MD (2002)
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLF1
  • NTC77
  • SYF3
  • YLR117C
    		•  The BioGRID Database Seperator Clf1p|Essential splicesome assembly factor; contains multiple tetratricopeptide repeat (TPR) protein-binding motifs and interacts specifically with many spliceosome components, may serve as a scaffold during splicesome assembly; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    Synthetic Growth Defect
    bait Vincent K (2003)
    Synthetic Lethality
    hit Ben-Yehuda S (2000)
    hit Russell CS (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLU7
  • SLT17
  • YDR088C
    		•  The BioGRID Database Seperator RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain|Slu7p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    bait Jurica MS (2002)
    Synthetic Lethality
    hit Ben-Yehuda S (2000)
    hit Jones MH (1995)
    bait/hit Xu D (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP8
  • DBF3
  • DNA39
  • RNA8
  • YHR165C
    		•  The BioGRID Database Seperator Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa|Prp8p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Ben-Yehuda S (2000)
    bait Umen JG (1995)
    Synthetic Rescue
    hit Ben-Yehuda S (2000)
    Phenotypic Suppression
    hit Kaplan Y (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYF1
  • NTC90
  • YDR416W
    		•  The BioGRID Database Seperator Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression; similar to Drosophila crooked neck protein|Syf1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    Synthetic Lethality
    hit Ben-Yehuda S (2000)
    hit Russell CS (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNT309
  • NTC25
  • YPR101W
    		•  The BioGRID Database Seperator Component of NineTeen complex (NTC) containing Prp19p involved in mRNA splicing, interacts physically and genetically with Prp19p|Snt309p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ohi MD (2002)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP18
  • YGR006W
    		•  The BioGRID Database Seperator Prp18p|Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Seshadri V (1996)
    bait Jones MH (1995)
    hit Frank D (1992)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP38
  • YGR075C
    		•  The BioGRID Database Seperator Prp38p|Unique component of the U4/U6.U5 tri-snRNP particle, dispensable for spliceosome assembly, but required for conformational changes which lead to catalytic activation of the spliceosome; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSF2
  • CDC102
  • YJL072C
    		•  The BioGRID Database Seperator Psf2p|Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB1
  • YML085C
    		•  The BioGRID Database Seperator Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules|Tub1p; protein coding
    Gene Ontology: [View List]
    Synthetic Rescue
    hit Chawla G (2003)
    hit Burns CG (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAP95
  • RSL1
  • YLR347C
    		•  The BioGRID Database Seperator Kap95p|Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP24
  • YMR268C
    		•  The BioGRID Database Seperator Prp24p|Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SYF2
  • NTC31
  • YGR129W
    		•  The BioGRID Database Seperator Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression|Syf2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Ben-Yehuda S (2000)
    hit Russell CS (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP60
  • CPN60
  • MIF4
  • YLR259C
    		•  The BioGRID Database Seperator Hsp60p|Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG13
  • YGL047W
    		•  The BioGRID Database Seperator Alg13p|Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSC11
  • AVO3
  • YER093C
    		•  The BioGRID Database Seperator Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain|Tsc11p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM2
  • SLT11
  • YBR065C
    		•  The BioGRID Database Seperator Ecm2p|Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Ben-Yehuda S (2000)
    bait/hit Xu D (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFA2
  • BUF1
  • RPA2
  • YNL312W
    		•  The BioGRID Database Seperator Rfa2p|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTS2
  • YOR077W
    		•  The BioGRID Database Seperator Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication|Rts2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRQ1
  • YDR373W
    		•  The BioGRID Database Seperator Frq1p|N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKS1
  • YBR135W
    		•  The BioGRID Database Seperator Cks1p|Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPI10
  • YGL142C
    		•  The BioGRID Database Seperator Gpi10p|Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Davierwala AP (2005)
    hit Mnaimneh S (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJU2
  • CWC16
  • YKL095W
    		•  The BioGRID Database Seperator Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing|Yju2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STO1
  • CBC1
  • CBP80
  • GCR3
  • YMR125W
    		•  The BioGRID Database Seperator Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80|Sto1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPP382
  • CCF8
  • NTR1
  • YLR424W
    		•  The BioGRID Database Seperator Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation|Spp382p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Hazbun TR (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSM4
  • DOA10
  • KIS3
  • YIL030C
    		•  The BioGRID Database Seperator Ssm4p|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Schuberth C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CBC2
  • CBP20
  • MUD13
  • SAE1
  • YPL178W
    		•  The BioGRID Database Seperator Cbc2p|Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC40
  • PRP17
  • SLT15
  • SLU4
  • YDR364C
    		•  The BioGRID Database Seperator Cdc40p|Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNU114
  • GIN10
  • YKL173W
    		•  The BioGRID Database Seperator GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2|Snu114p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CWC22
  • YGR278W
    		•  The BioGRID Database Seperator Cwc22p|Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP46
  • NTC50
  • YPL151C
    		•  The BioGRID Database Seperator Prp46p|Splicing factor that is found in the Cef1p subcomplex of the spliceosome; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRR2
  • PRP44
  • RSS1
  • SLT22
  • YER172C
    		•  The BioGRID Database Seperator Brr2p|RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADH1
  • ADC1
  • YOL086C
    		•  The BioGRID Database Seperator Adh1p|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Kaplan Y (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPM1
  • YKL152C
    		•  The BioGRID Database Seperator Gpm1p|Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Kaplan Y (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TDH3
  • GLD1
  • HSP35
  • HSP36
  • YGR192C
    		•  The BioGRID Database Seperator Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall|Tdh3p; protein coding
    Gene Ontology: [View List]