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BioGRID | Network Layout for SKP1 for Saccharomyces cerevisiae
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SKP1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: MGO1, YDR328C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase|Skp1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 23 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SKP1

SKP1 was identified with 220 protein interactions and 26 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 GRR1
  • CAT80
  • COT2
  • SSU2
  • YJR090C
    		•  The BioGRID Database Seperator F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification|Grr1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Two-hybrid
    hit Uetz P (2000)
    bait Li FN (1997)
    hit Seol JH (2001)
    hit Galan JM (1999)
    Affinity Capture-Western
    bait Hsiung YG (2001)
    bait Skowyra D (1999)
    bait Skowyra D (1997)
    bait Li FN (1997)
    hit Seol JH (2001)
    hit Kishi T (1998)
    bait Willems AR (1999)
    bait Galan JM (1999)
    hit Patton EE (1998)
    Reconstituted Complex
    bait Li FN (1997)
    hit Kishi T (1998)
    hit Kus BM (2004)
    Dosage Lethality
    hit Li FN (1997)
    Dosage Rescue
    bait Kishi T (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC53
  • YDL132W
    		•  The BioGRID Database Seperator Cdc53p|Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Ho Y (2002)
    bait Willems AR (1999)
    bait/hit Tagwerker C (2006)
    bait Collins SR (2007)
    Two-hybrid
    bait Uetz P (2000)
    bait Seol JH (2001)
    bait Patton EE (1998)
    bait Michel JJ (2003)
    Affinity Capture-Western
    bait Patton EE (1998)
    bait Skowyra D (1997)
    hit Galan JM (2001)
    hit Seol JH (2001)
    bait/hit Barbey R (2005)
    bait Kondo-Okamoto N (2006)
    bait Kurz T (2008)
    Reconstituted Complex
    hit Feldman RM (1997)
    bait Kus BM (2004)
    Synthetic Lethality
    bait Patton EE (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC4
  • YFL009W
    		•  The BioGRID Database Seperator Cdc4p|F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Ho Y (2002)
    bait/hit Tagwerker C (2006)
    Two-hybrid
    hit Uetz P (2000)
    hit Seol JH (2001)
    bait/hit Dixon C (2003)
    Affinity Capture-Western
    bait Kamura T (1999)
    hit Skowyra D (1997)
    bait Bai C (1996)
    hit Patton EE (1998)
    hit Barbey R (2005)
    Reconstituted Complex
    bait Feldman RM (1997)
    hit Kus BM (2004)
    bait Nash P (2001)
    hit Weerasekera R (2007)
    Co-crystal Structure
    hit Orlicky S (2003)
    Phenotypic Suppression
    bait Bai C (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF13
  • YMR094W
    		•  The BioGRID Database Seperator Ctf13p|Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Two-hybrid
    hit Uetz P (2000)
    hit Seol JH (2001)
    Affinity Capture-Western
    hit Kitagawa K (1999)
    bait Rodrigo-Brenni MC (2004)
    bait Lingelbach LB (2004)
    bait/hit Bansal PK (2004)
    Reconstituted Complex
    hit Stemmann O (2002)
    hit Kus BM (2004)
    bait Rodrigo-Brenni MC (2004)
    hit Kaplan KB (1997)
    Co-purification
    hit Russell ID (1999)
    Dosage Rescue
    hit Hyland KM (1999)
    bait Connelly C (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGT1
  • YOR057W
    		•  The BioGRID Database Seperator Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex|Sgt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    Two-hybrid
    hit Uetz P (2000)
    hit Seol JH (2001)
    Affinity Capture-Western
    bait Kitagawa K (1999)
    bait/hit Rodrigo-Brenni MC (2004)
    bait Lingelbach LB (2004)
    hit Bansal PK (2004)
    Reconstituted Complex
    bait Rodrigo-Brenni MC (2004)
    hit Lingelbach LB (2004)
    hit Bansal PK (2004)
    bait Catlett MG (2006)
    Dosage Rescue
    bait/hit Kitagawa K (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET30
  • ZRG11
  • YIL046W
    		•  The BioGRID Database Seperator F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus|Met30p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Two-hybrid
    hit Uetz P (2000)
    hit Seol JH (2001)
    bait Brunson LE (2004)
    hit Dixon C (2003)
    Affinity Capture-Western
    bait Rouillon A (2000)
    bait Kaiser P (1998)
    bait Willems AR (1999)
    bait/hit Brunson LE (2004)
    bait/hit Barbey R (2005)
    Dosage Rescue
    bait Kaiser P (1998)
    bait Brunson LE (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFO1
  • YML088W
    		•  The BioGRID Database Seperator F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation|Ufo1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Ho Y (2002)
    bait/hit Tagwerker C (2006)
    Two-hybrid
    bait Uetz P (2000)
    bait Kaplun L (2003)
    Reconstituted Complex
    hit Kus BM (2004)
    Affinity Capture-Western
    bait Kaplun L (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RCY1
  • YJL204C
    		•  The BioGRID Database Seperator F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth|Rcy1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Galan JM (2001)
    hit Seol JH (2001)
    Two-hybrid
    bait/hit Galan JM (2001)
    Reconstituted Complex
    hit Kus BM (2004)
    Affinity Capture-MS
    bait/hit Tagwerker C (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRT3
  • YLR097C
    		•  The BioGRID Database Seperator Hrt3p|Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    hit Seol JH (2001)
    Two-hybrid
    hit Uetz P (2000)
    Reconstituted Complex
    hit Kus BM (2004)
    Affinity Capture-Western
    bait Willems AR (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR258C
  • YMR258C
    		•  The BioGRID Database Seperator Protein of unknown function with similarity to F-box proteins; physically interacts with Skp1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR258C is not an essential gene|Ymr258cp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Seol JH (2001)
    bait Krogan NJ (2006)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAV1
  • SOI3
  • YJR033C
    		•  The BioGRID Database Seperator Rav1p|Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Smardon AM (2002)
    hit Seol JH (2001)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait/hit Tagwerker C (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRT1
  • HRT2
  • RBX1
  • ROC1
  • YOL133W
    		•  The BioGRID Database Seperator Hrt1p|RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Seol JH (1999)
    bait Kamura T (1999)
    Affinity Capture-MS
    hit Seol JH (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAV2
  • YDR202C
    		•  The BioGRID Database Seperator Rav2p|Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Seol JH (2001)
    Affinity Capture-MS
    bait Gavin AC (2006)
    bait Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC34
  • DNA6
  • UBC3
  • YDR054C
    		•  The BioGRID Database Seperator Cdc34p|Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Feldman RM (1997)
    Affinity Capture-Western
    bait Patton EE (1998)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT52
  • YKR014C
    		•  The BioGRID Database Seperator GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis|Ypt52p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    bait/hit Tagwerker C (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKP2
  • YNL311C
    		•  The BioGRID Database Seperator Protein of unknown function that may interact with ribosomes, based on co-purification experiments; putative F-box protein; analysis of integrated high-throughput datasets predicts involvement in ubiquitin-dependent protein catabolism|Skp2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    bait/hit Tagwerker C (2006)
    Reconstituted Complex
    hit Kus BM (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJL149W
  • DAS1
    		•  The BioGRID Database Seperator Das1p|Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Reconstituted Complex
    hit Kus BM (2004)
    Affinity Capture-Western
    bait Willems AR (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DIA2
  • YOR29-31
  • YOR080W
    		•  The BioGRID Database Seperator Dia2p|Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    Reconstituted Complex
    hit Kus BM (2004)
    Affinity Capture-Western
    hit Koepp DM (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CEP3
  • CBF3
  • CSL1
  • YMR168C
    		•  The BioGRID Database Seperator Cep3p|Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Westermann S (2003)
    Affinity Capture-Western
    hit Seol JH (2001)
    Reconstituted Complex
    hit Kaplan KB (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB1
  • YGR188C
    		•  The BioGRID Database Seperator Bub1p|Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p; protein coding
    Gene Ontology: [View List]