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BioGRID | Network Layout for MTH1 for Saccharomyces cerevisiae
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MTH1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: DGT1, HTR1, BPC1, YDR277C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 3 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with MTH1

MTH1 was identified with 27 protein interactions and 34 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 RGT1
  • YKL038W
    		•  The BioGRID Database Seperator Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lakshmanan J (2003) [4]
    Two-hybrid
    bait Lakshmanan J (2003) [4]
    bait Polish JA (2005) [7]
    Reconstituted Complex
    bait Polish JA (2005) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF3
  • YDL194W
    		•  The BioGRID Database Seperator Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
    Gene Ontology: [View List]
    Two-hybrid
    hit Lafuente MJ (2000) [5]
    hit Schmidt MC (1999) [6]
    Synthetic Rescue
    bait Lafuente MJ (2000) [5]
    bait Schmidt MC (1999) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RGT2
  • YDL138W
    		•  The BioGRID Database Seperator Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
    Gene Ontology: [View List]
    Two-hybrid
    hit Lafuente MJ (2000) [5]
    Synthetic Rescue
    bait Lafuente MJ (2000) [5]
    bait Schmidt MC (1999) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM8
  • YJR022W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
    Gene Ontology: [View List]
    Two-hybrid
    bait Fromont-Racine M (2000) [266]
    bait Fromont-Racine M (1997) [167]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VMA6
  • YLR447C
    		•  The BioGRID Database Seperator Subunit D of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001) [1585]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STD1
  • SFS3
  • MSN3
  • YOR047C
    		•  The BioGRID Database Seperator Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Hubbard EJ (1994) [6]
    hit Ganster RW (1998) [4]
    hit Sabina J (2009) [1]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
    Gene Ontology: [View List]
    Two-hybrid
    bait Zhao R (2005) [489]
    Synthetic Growth Defect
    bait McClellan AJ (2007) [1419]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT3
  • YDR345C
    		•  The BioGRID Database Seperator Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
    Gene Ontology: [View List]
    Dosage Rescue
    hit Ozcan S (1993) [3]
    hit Gamo FJ (1994) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT1
  • HOR4
  • YHR094C
    		•  The BioGRID Database Seperator Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
    Gene Ontology: [View List]
    Dosage Rescue
    hit Ozcan S (1993) [3]
    hit Gamo FJ (1994) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYO5
  • YMR109W
    		•  The BioGRID Database Seperator One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEX13
  • PAS20
  • YLR191W
    		•  The BioGRID Database Seperator Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYO3
  • YKL129C
    		•  The BioGRID Database Seperator One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA1
  • YBL007C
    		•  The BioGRID Database Seperator Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NBP2
  • YDR162C
    		•  The BioGRID Database Seperator Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABP1
  • YCR088W
    		•  The BioGRID Database Seperator Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSK1
  • YNL073W
    		•  The BioGRID Database Seperator Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
    Gene Ontology: [View List]
    Two-hybrid
    bait Brandina I (2007) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSE1
  • YHL002W
    		•  The BioGRID Database Seperator Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRR1
  • CAT80
  • COT2
  • SDC1
  • YJR090C
    		•  The BioGRID Database Seperator F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Spielewoy N (2004) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BBC1
  • MTI1
  • YJL021C
  • YJL020C
    		•  The BioGRID Database Seperator Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BZZ1
  • LSB7
  • YHR114W
    		•  The BioGRID Database Seperator SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD14
  • YAR014C
    		•  The BioGRID Database Seperator Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOI1
  • BOB1
  • GIN7
  • YBL085W
    		•  The BioGRID Database Seperator Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
    Gene Ontology: [View List]
    Two-hybrid
    bait Tonikian R (2009) [751]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTK3
  • YML112W
    		•  The BioGRID Database Seperator Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FMC1
  • YIL098C
    		•  The BioGRID Database Seperator Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STP2
  • YHR006W
    		•  The BioGRID Database Seperator Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RCN2
  • YOR220W
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS29
  • PEP11
  • YHR012W
    		•  The BioGRID Database Seperator Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP4
  • RNA4
  • YPR178W
    		•  The BioGRID Database Seperator Splicing factor, component of the U4/U6-U5 snRNP complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR130C
  • YGR130C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG9
  • YNL219C
    		•  The BioGRID Database Seperator Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLC1
  • SCD4
  • YGR167W
    		•  The BioGRID Database Seperator Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function, two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YEL057C
  • YEL057C
    		•  The BioGRID Database Seperator Protein of unknown function involved in telomere maintenance; target of UME6 regulation
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPL264C
  • YPL264C
    		•  The BioGRID Database Seperator Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
    Gene Ontology: [View List]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT2
  • YMR011W
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
    Gene Ontology: [View List]
    Dosage Rescue
    hit Gamo FJ (1994) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POP4
  • YBR257W
    		•  The BioGRID Database Seperator Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait McClellan AJ (2007) [1419]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GPR1
  • YDL035C
    		•  The BioGRID Database Seperator Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Belinchon MM (2007) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT4
  • RAG1
  • LGT1
  • YHR092C
    		•  The BioGRID Database Seperator High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
    Gene Ontology: [View List]
    Dosage Rescue
    hit Ozcan S (1993) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TFP1
  • VMA1
  • CLS8
  • YDL185W
    		•  The BioGRID Database Seperator Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSS2
  • YDL107W
    		•  The BioGRID Database Seperator Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS41
  • VAM2
  • CVT8
  • SVL2
  • YDR080W
    		•  The BioGRID Database Seperator Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GET3
  • ARR4
  • YDL100C
    		•  The BioGRID Database Seperator ATPase, subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; involved in resistance to heat and metal stress
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AGP1
  • YCC5
  • YCL025C
    		•  The BioGRID Database Seperator Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUT1
  • MED5
  • YGL151W
    		•  The BioGRID Database Seperator Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
    Gene Ontology: [View List]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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