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BioGRID | Network Layout for SLY1 for Saccharomyces cerevisiae
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SLY1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YDR189W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex|Sly1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 9 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SLY1

SLY1 was identified with 48 protein interactions and 54 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SED5
  • YLR026C
    		•  The BioGRID Database Seperator Sed5p|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Ito T (2001)
    hit Yamaguchi T (2002)
    Affinity Capture-Western
    bait Kosodo Y (2003)
    bait Kosodo Y (2002)
    bait/hit Peng R (2002)
    bait/hit Peng R (2004)
    bait Dulubova I (2002)
    hit Lupashin VV (1997)
    hit Li Y (2005)
    bait Søgaard M (1994)
    Co-crystal Structure
    bait Bracher A (2002)
    Reconstituted Complex
    bait Yamaguchi T (2002)
    bait Grabowski R (1997)
    bait/hit Peng R (2002)
    bait/hit Peng R (2004)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Dosage Rescue
    bait Braun S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFE1
  • YOR075W
    		•  The BioGRID Database Seperator Ufe1p|t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Yamaguchi T (2002)
    Two-hybrid
    hit Yamaguchi T (2002)
    bait/hit Braun S (2007)
    Affinity Capture-Western
    bait/hit Li Y (2005)
    Dosage Rescue
    bait Braun S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOS1
  • SEC32
  • YLR078C
    		•  The BioGRID Database Seperator Bos1p|v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Peng R (2002)
    hit Li Y (2005)
    bait Søgaard M (1994)
    Reconstituted Complex
    bait Peng R (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC22
  • SLY2
  • TSL26
  • YLR268W
    		•  The BioGRID Database Seperator R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog|Sec22p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Peng R (2002)
    Reconstituted Complex
    bait Peng R (2002)
    Phenotypic Suppression
    bait Ossig R (1991)
    Synthetic Rescue
    bait Ossig R (1991)
    Synthetic Lethality
    hit Li Y (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BET1
  • SLY12
  • YIL004C
    		•  The BioGRID Database Seperator Bet1p|Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Peng R (2002)
    hit Li Y (2005)
    Reconstituted Complex
    bait Peng R (2004)
    Dosage Rescue
    hit Kosodo Y (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT1
  • YFL038C
    		•  The BioGRID Database Seperator Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)|Ypt1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Dascher C (1991)
    Phenotypic Suppression
    bait Grabowski R (1997)
    bait Ossig R (1991)
    Synthetic Rescue
    bait Li B (1998)
    bait Ossig R (1991)
    bait Li Y (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DSL1
  • RNS1
  • YNL258C
    		•  The BioGRID Database Seperator Dsl1p|Peripheral membrane protein required for Golgi-to-ER retrograde traffic; component of the ER target site that interacts with coatomer, the major component of the COPI vesicle protein coat; also interacts with Cin5p and Sec39p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Vanrheenen SM (2001)
    Synthetic Lethality
    bait Andag U (2001)
    hit Vanrheenen SM (2001)
    hit Li Y (2005)
    Synthetic Rescue
    bait Andag U (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Bensen ES (2001)
    Synthetic Rescue
    bait Li B (1998)
    bait Li Y (2007)
    Synthetic Lethality
    bait Luo Z (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG3
  • GRD20
  • SEC34
  • YER157W
    		•  The BioGRID Database Seperator Cog3p|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    Dosage Rescue
    bait Ram RJ (2002)
    bait VanRheenen SM (1999)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKT6
  • YKL196C
    		•  The BioGRID Database Seperator Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus|Ykt6p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    Reconstituted Complex
    bait Peng R (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     USO1
  • INT1
  • YDL058W
    		•  The BioGRID Database Seperator Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex|Uso1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Kito M (1996)
    hit Kosodo Y (2001)
    Synthetic Lethality
    hit Vanrheenen SM (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG4
  • COD1
  • SEC38
  • SGF1
  • YPR105C
    		•  The BioGRID Database Seperator Cog4p|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    Dosage Rescue
    bait Ram RJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC39
  • YLR440C
    		•  The BioGRID Database Seperator Protein of unknown function proposed to be involved in protein secretion; interacts with Dsl1p and localizes to the ER and nuclear envelope|Sec39p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Kraynack BA (2005)
    Dosage Rescue
    bait Kraynack BA (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC20
  • YDR498C
    		•  The BioGRID Database Seperator Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p|Sec20p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Li Y (2005)
    Synthetic Lethality
    hit Li Y (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE1
  • YER012W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle|Pre1p; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    hit Braun S (2007)
    Synthetic Lethality
    hit Braun S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG2
  • SEC35
  • YGR120C
    		•  The BioGRID Database Seperator Cog2p|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Ram RJ (2002)
    bait VanRheenen SM (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     COG1
  • COD3
  • LDB11
  • SEC36
  • YGL223C
    		•  The BioGRID Database Seperator Cog1p|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Ram RJ (2002)
    Synthetic Lethality
    bait Ram RJ (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RBD2
  • YPL246C
    		•  The BioGRID Database Seperator Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p|Rbd2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC17
  • RNS3
  • YBL050W
    		•  The BioGRID Database Seperator Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP|Sec17p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRH1
  • YDR517W
    		•  The BioGRID Database Seperator Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes|Grh1p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HXT1
  • HOR4
  • YHR094C
    		•  The BioGRID Database Seperator Hxt1p|Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     USE1
  • SLT1
  • YGL098W
    		•  The BioGRID Database Seperator Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p|Use1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Li Y (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFT1
  • YKL006C-A
    		•  The BioGRID Database Seperator Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment|Sft1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Peng R (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNC2
  • YOR327C
    		•  The BioGRID Database Seperator Snc2p|Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Peng R (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNC1
  • YAL030W
    		•  The BioGRID Database Seperator Snc1p|Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Peng R (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PFK26
  • YIL107C
    		•  The BioGRID Database Seperator 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A|Pfk26p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GOS1
  • YHL031C
    		•  The BioGRID Database Seperator Gos1p|v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Peng R (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNA3
  • YJL151C
    		•  The BioGRID Database Seperator Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting|Sna3p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PCL2
  • CLN4
  • YDL127W
    		•  The BioGRID Database Seperator G1 cyclin, associates with Pho85p cyclin-dependent kinase (Cdk) to contribute to entry into the mitotic cell cycle, essential for cell morphogenesis; localizes to sites of polarized cell growth|Pcl2p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TVP15
  • YDR100W
    		•  The BioGRID Database Seperator Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p|Tvp15p; protein coding
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC18
  • ANU4
  • YBR080C
    		•  The BioGRID Database Seperator ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF|Sec18p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Kosodo Y (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS53
  • YJL029C
    		•  The BioGRID Database Seperator Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting|Vps53p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Vanrheenen SM (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC21
  • YNL287W
    		•  The BioGRID Database Seperator Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo|Sec21p; protein coding
    Gene Ontology: [View List]