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BioGRID | Network Layout for SUP35 for Saccharomyces cerevisiae
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SUP35

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: GST1, PNM2, SAL3, SUF12, SUP2, SUP36, YDR172W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Sup35p|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SUP35

SUP35 was identified with 97 protein interactions and 18 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SUP45
  • SAL4
  • SUP1
  • SUP47
  • YBR143C
    		•  The BioGRID Database Seperator Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor|Sup45p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    bait/hit Gavin AC (2002)
    bait Kobayashi T (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Reconstituted Complex
    bait Stansfield I (1995)
    hit Ebihara K (1999)
    hit Eurwilaichitr L (1999)
    Two-hybrid
    bait/hit Stansfield I (1995)
    hit Ebihara K (1999)
    hit Eurwilaichitr L (1999)
    hit Fabret C (2008)
    Affinity Capture-Western
    bait Paushkin SV (1997)
    hit Gross T (2007)
    bait Akhmaloka (2008)
    Biochemical Activity
    hit Fabret C (2008)
    Dosage Rescue
    hit Derkatch IL (1998)
    hit Kobayashi T (2004)
    Phenotypic Enhancement
    hit Stansfield I (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUP35
  • GST1
  • PNM2
  • SAL3
  • YDR172W
    		•  The BioGRID Database Seperator Sup35p|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Krogan NJ (2004)
    Reconstituted Complex
    hit Collins SR (2004)
    hit Hess S (2007)
    hit Shewmaker F (2008)
    hit Kalastavadi T (2008)
    bait/hit Savistchenko J (2008)
    Co-purification
    hit Wei HY (2006)
    Co-crystal Structure
    hit Hess S (2007)
    hit Shewmaker F (2008)
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA1
  • YG100
  • YAL005C
    		•  The BioGRID Database Seperator ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall|Ssa1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Allen KD (2005)
    bait/hit Savistchenko J (2008)
    Affinity Capture-Western
    hit Allen KD (2005)
    bait/hit Bagriantsev SN (2008)
    Co-purification
    bait Krzewska J (2006)
    Affinity Capture-MS
    hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAM7
  • IFS2
  • MOF4
  • UPF1
  • YMR080C
    		•  The BioGRID Database Seperator ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance|Nam7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wang W (2001)
    hit Kobayashi T (2004)
    hit Czaplinski K (1998)
    Reconstituted Complex
    bait Wang W (2001)
    Phenotypic Suppression
    hit Wilson MA (2005)
    Dosage Lethality
    hit Kodama H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAB1
  • YER165W
    		•  The BioGRID Database Seperator Pab1p|Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Cosson B (2002)
    Two-hybrid
    hit Cosson B (2002)
    Affinity Capture-Western
    bait/hit Hosoda N (2003)
    hit Kobayashi T (2004)
    Dosage Lethality
    hit Kodama H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP104
  • YLL026W
    		•  The BioGRID Database Seperator Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation|Hsp104p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Narayanan S (2003)
    hit Schirmer EC (1997)
    Co-localization
    bait Inoue Y (2004)
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA1
  • YBL007C
    		•  The BioGRID Database Seperator Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains|Sla1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Bailleul PA (1999)
    hit Ganusova EE (2006)
    Phenotypic Enhancement
    bait Bailleul PA (1999)
    Dosage Lethality
    hit Kodama H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UPF3
  • SUA6
  • YGR072W
    		•  The BioGRID Database Seperator Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance|Upf3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wang W (2001)
    Reconstituted Complex
    bait Wang W (2001)
    Dosage Lethality
    hit Kodama H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NMD2
  • IFS1
  • SUA1
  • UPF2
  • YHR077C
    		•  The BioGRID Database Seperator Nmd2p|Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wang W (2001)
    Reconstituted Complex
    bait Wang W (2001)
    Dosage Lethality
    hit Kodama H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA2
  • END4
  • MOP2
  • YNL243W
    		•  The BioGRID Database Seperator Sla2p|Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ganusova EE (2006)
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDJ1
  • HSP40
  • MAS5
  • YNL064C
    		•  The BioGRID Database Seperator Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family|Ydj1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    Reconstituted Complex
    bait/hit Savistchenko J (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUI3
  • YPL237W
    		•  The BioGRID Database Seperator Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding|Sui3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS5
  • GRD2
  • PEP10
  • VPT5
  • YOR069W
    		•  The BioGRID Database Seperator Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p|Vps5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSA2
  • YG102
  • YLL024C
    		•  The BioGRID Database Seperator ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall|Ssa2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Bagriantsev SN (2008)
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRPL23
  • YOR150W
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the large subunit|Mrpl23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSB1
  • YG101
  • YDL229W
    		•  The BioGRID Database Seperator Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p|Ssb1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Allen KD (2005)
    Affinity Capture-Western
    hit Allen KD (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB6
  • YML117W
    		•  The BioGRID Database Seperator Nab6p|Putative RNA-binding protein, based on computational analysis of large-scale protein-protein interaction data; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ITT1
  • YML068W
    		•  The BioGRID Database Seperator Itt1p|Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Urakov VN (2001)
    Dosage Lethality
    hit Kodama H (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATXN3
  • ATX3
  • MJD
  • MJD1
  • EG4287
    		•  The BioGRID Database Seperator Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3)|josephin; ataxin 3
    Gene Ontology: [View List]
    Co-localization
    hit Li LB (2007)
    Phenotypic Suppression
    hit Li LB (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP2
  • ACT2
  • YDL029W
    		•  The BioGRID Database Seperator Arp2p|Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ganusova EE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL16B
  • RP23
  • YNL069C
    		•  The BioGRID Database Seperator N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p|Rpl16bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AHP1
  • YLR109W
    		•  The BioGRID Database Seperator Ahp1p|Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock|Hsc82p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP3
  • ACT4
  • YJR065C
    		•  The BioGRID Database Seperator Arp3p|Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Ganusova EE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Ganusova EE (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIS1
  • YNL007C
    		•  The BioGRID Database Seperator Sis1p|Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK1
  • PKA1
  • SRA3
  • YJL164C
    		•  The BioGRID Database Seperator Tpk1p|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Fabret C (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SSE1
  • LPG3
  • MSI3
  • YPL106C
    		•  The BioGRID Database Seperator ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm|Sse1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Bagriantsev SN (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TDH1
  • GLD3
  • YJL052W
    		•  The BioGRID Database Seperator Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall|Tdh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DCP1
  • YOL149W
    		•  The BioGRID Database Seperator Dcp1p|Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Kofuji S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator