The BioGRID Database Seperator
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BioGRID | Network Layout for SAC3 for Saccharomyces cerevisiae
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SAC3

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: LEP1, YDR159W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 14 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SAC3

SAC3 was identified with 97 protein interactions and 461 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 THP1
  • BUD29
  • YOL072W
    		•  The BioGRID Database Seperator Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rodriguez-Navarro S (2004) [74]
    hit Collins SR (2007) [9064]
    hit Oeffinger M (2007) [375]
    Affinity Capture-Western
    hit Fischer T (2002) [26]
    bait Koehler A (2008) [42]
    hit Wilmes GM (2008) [6467]
    bait Faza MB (2009) [11]
    hit Jani D (2009) [11]
    bait Kloeckner C (2009) [16]
    Positive Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUS1
  • YBR111W-A
    		•  The BioGRID Database Seperator Protein involved in mRNA export coupled transcription activation; component of the SAGA histone acetylase complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rodriguez-Navarro S (2004) [74]
    bait Koehler A (2006) [15]
    hit Oeffinger M (2007) [375]
    bait Koehler A (2008) [42]
    bait Pascual-Garcia P (2008) [18]
    Affinity Capture-Western
    bait Koehler A (2008) [42]
    bait/hit Jani D (2009) [11]
    bait Kloeckner C (2009) [16]
    Reconstituted Complex
    hit Ellisdon AM (2009) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC31
  • DSK1
  • YOR257W
    		•  The BioGRID Database Seperator Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; interacts with Kar1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Fischer T (2004) [12]
    bait Krogan NJ (2006) [7079]
    hit Oeffinger M (2007) [375]
    Affinity Capture-Western
    bait/hit Fischer T (2004) [12]
    hit Jani D (2009) [11]
    bait Kloeckner C (2009) [16]
    Reconstituted Complex
    bait Fischer T (2004) [12]
    Dosage Rescue
    hit Fischer T (2004) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEX67
  • YPL169C
    		•  The BioGRID Database Seperator Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lei EP (2003) [6]
    hit Fischer T (2002) [26]
    Reconstituted Complex
    hit Fischer T (2002) [26]
    Affinity Capture-MS
    bait/hit Oeffinger M (2007) [375]
    Synthetic Lethality
    hit Fischer T (2002) [26]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MTR2
  • YKL186C
    		•  The BioGRID Database Seperator mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lei EP (2003) [6]
    Reconstituted Complex
    hit Fischer T (2002) [26]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Synthetic Lethality
    bait Lei EP (2003) [6]
    hit Fischer T (2002) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEM1
  • DSS1
  • HOD1
  • YDR363W-A
    		•  The BioGRID Database Seperator Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Wilmes GM (2008) [6467]
    hit Faza MB (2009) [11]
    Positive Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP5
  • RAT8
  • YOR046C
    		•  The BioGRID Database Seperator Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lei EP (2003) [6]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    hit Wilmes GM (2008) [6467]
    Synthetic Lethality
    bait Scarcelli JJ (2008) [96]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP60
  • YAR002W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Lutzmann M (2005) [112]
    hit Oeffinger M (2007) [375]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SUB2
  • YDL084W
    		•  The BioGRID Database Seperator Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Fischer T (2002) [26]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Dosage Growth Defect
    hit Gonzalez-Aguilera C (2008) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP116
  • NSP116
  • YMR047C
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lei EP (2003) [6]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Synthetic Lethality
    hit Fischer T (2002) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BIM1
  • YEB1
  • YER016W
    		•  The BioGRID Database Seperator Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004) [3873]
    Synthetic Growth Defect
    bait Pan X (2004) [323]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HTZ1
  • HTA3
  • YOL012C
    		•  The BioGRID Database Seperator Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    bait Venkatasubrahmanyam S (2007) [52]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRC1
  • YML033W
  • HEH1
  • YML034W
    		•  The BioGRID Database Seperator Inner nuclear membrane (INM) protein with a putative role in sister chromatid segregation, potentially phosphorylated by Cdc28p; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    bait/hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    hit Grund SE (2008) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN3
  • CPE1
  • SDI1
  • SDS16
  • YOL004W
    		•  The BioGRID Database Seperator Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    bait/hit Costanzo M (2010) [68487]
    Synthetic Growth Defect
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP170
  • NLE3
  • YBL079W
    		•  The BioGRID Database Seperator Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP188
  • YML103C
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP100
  • NSP100
  • YKL068W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POM34
  • YLR018C
    		•  The BioGRID Database Seperator Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CBC2
  • MUD13
  • CBP20
  • SAE1
  • YPL178W
    		•  The BioGRID Database Seperator Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLE2
  • RAE1
  • YER107C
    		•  The BioGRID Database Seperator Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Synthetic Lethality
    hit Fischer T (2002) [26]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NSP1
  • YJL041W
    		•  The BioGRID Database Seperator Essential component of the nuclear pore complex, which mediates nuclear import and export
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Jones AL (2000) [5]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP1
  • YOR098C
    		•  The BioGRID Database Seperator Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Fischer T (2002) [26]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLP1
  • MPL1
  • YKR095W
    		•  The BioGRID Database Seperator Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lei EP (2003) [6]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADA2
  • SWI8
  • YDR448W
    		•  The BioGRID Database Seperator Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rodriguez-Navarro S (2004) [74]
    Affinity Capture-Western
    bait Koehler A (2008) [42]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PHO23
  • YNL097C
    		•  The BioGRID Database Seperator Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOH1
  • MED31
  • YGL127C
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP6
  • YLR085C
    		•  The BioGRID Database Seperator Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRP6
  • YOR001W
    		•  The BioGRID Database Seperator Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT8
  • YLR055C
    		•  The BioGRID Database Seperator Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ingvarsdottir K (2005) [143]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Lin YY (2008) [2599]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSE2
  • MED9
  • YNR010W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP8
  • YMR223W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ingvarsdottir K (2005) [143]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWR1
  • YDR334W
    		•  The BioGRID Database Seperator Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KEM1
  • SKI1
  • DST2
  • RAR5
  • YGL173C
    		•  The BioGRID Database Seperator Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS71
  • SWC6
  • YML041C
    		•  The BioGRID Database Seperator Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP82
  • HRB187
  • YJL061W
    		•  The BioGRID Database Seperator Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP84
  • YDL116W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP133
  • RAT3
  • YKR082W
    		•  The BioGRID Database Seperator Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NIC96
  • YFR002W
    		•  The BioGRID Database Seperator Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NPL3
  • MTR13
  • MTS1
  • NAB1
  • YDR432W
    		•  The BioGRID Database Seperator RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STO1
  • CBP80
  • GCR3
  • CBC1
  • YMR125W
    		•  The BioGRID Database Seperator Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MLP2
  • YIL149C
    		•  The BioGRID Database Seperator Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGF11
  • YPL047W
    		•  The BioGRID Database Seperator Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Ellisdon AM (2009) [3]
    Synthetic Lethality
    bait Ingvarsdottir K (2005) [143]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YRA1
  • SHE11
  • YDR381W
    		•  The BioGRID Database Seperator Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Oeffinger M (2007) [375]
    Synthetic Lethality
    bait/hit Fischer T (2002) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP120
  • RAT2
  • YKL057C
    		•  The BioGRID Database Seperator Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAT1
  • MRT1
  • YCR077C
    		•  The BioGRID Database Seperator Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRP1
  • RRP47
  • YHR081W
    		•  The BioGRID Database Seperator Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APQ12
  • YIL040W
    		•  The BioGRID Database Seperator Protein involved in nucleocytoplasmic transport of mRNA
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN4
  • UFD5
  • SON1
  • YDL020C
    		•  The BioGRID Database Seperator Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF18
  • CHL12
  • YMR078C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LGE1
  • YPL055C
    		•  The BioGRID Database Seperator Protein of unknown function; null mutant forms abnormally large cells
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRS4
  • YDR439W
    		•  The BioGRID Database Seperator Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
    Gene Ontology: [View List]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MED1
  • YPR070W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAP30
  • YMR263W
    		•  The BioGRID Database Seperator Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBP3
  • YGL078C
    		•  The BioGRID Database Seperator Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RXT2
  • RAF60
  • YBR095C
    		•  The BioGRID Database Seperator Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR054W
  • YGR054W
    		•  The BioGRID Database Seperator Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PAN3
  • ECM35
  • YKL025C
    		•  The BioGRID Database Seperator Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GBP2
  • RLF6
  • YCL011C
    		•  The BioGRID Database Seperator Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NMD5
  • KAP119
  • YJR132W
    		•  The BioGRID Database Seperator Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOF2
  • YKR010C
    		•  The BioGRID Database Seperator Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB3
  • YOR026W
    		•  The BioGRID Database Seperator Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SDC1
  • SAF19
  • CPS25
  • YDR469W
    		•  The BioGRID Database Seperator Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; has similarity to C. elegans Dpy-30
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BRE1
  • YDL074C
    		•  The BioGRID Database Seperator E3 ubiquitin ligase for Rad6p, required for the ubiquitination of histone H2B, recruitment of Rad6p to promoter chromatin and subsequent methylation of histone H3 (on K4 and K79), contains RING finger domain
    Gene Ontology: [View List]
    Negative Genetic
    hit Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SGF73
  • sca7
  • YGL066W
    		•  The BioGRID Database Seperator 73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    Synthetic Growth Defect
    bait Koehler A (2008) [42]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUL1
  • SMM2
  • RDS1
  • DAG1
  • YMR275C
    		•  The BioGRID Database Seperator Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKE2
  • GIM1
  • PFD6
  • YLR200W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAP1
  • GRF1
  • TUF1
  • TBA1
  • YNL216W
    		•  The BioGRID Database Seperator DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM3
  • PFD4
  • YNL153C
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSF1
  • YLR087C
    		•  The BioGRID Database Seperator Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC73
  • YLR418C
    		•  The BioGRID Database Seperator Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PDA1
  • YER178W
    		•  The BioGRID Database Seperator E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    Negative Genetic
    hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT103
  • YDR289C
    		•  The BioGRID Database Seperator Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLK19
  • YOR195W
    		•  The BioGRID Database Seperator Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WHI4
  • YDL224C
    		•  The BioGRID Database Seperator Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
    Gene Ontology: [View List]
    Positive Genetic
    hit Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • SUN1
  • MCB1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EAF1
  • VID21
  • YDR359C
    		•  The BioGRID Database Seperator Component of the NuA4 histone acetyltransferase complex
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    Synthetic Lethality
    bait Mitchell L (2008) [313]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAF130
  • YGR134W
    		•  The BioGRID Database Seperator Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT109
  • KIM2
  • REM50
  • YLL002W
    		•  The BioGRID Database Seperator Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTF8
  • YHR191C
    		•  The BioGRID Database Seperator Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA34
  • YJL148W
    		•  The BioGRID Database Seperator RNA polymerase I subunit A34.5
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOP1
  • MAK17
  • MAK1
  • YOL006C
    		•  The BioGRID Database Seperator Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAP120
  • YPL125W
    		•  The BioGRID Database Seperator Karyopherin with a role in the assembly or export of 60S ribosomal subunits
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU1
  • YBL034C
    		•  The BioGRID Database Seperator Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Amaro IA (2008) [69]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • SDI2
  • MOF6
  • REC3
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOP16
  • YER002W
    		•  The BioGRID Database Seperator Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARP8
  • YOR141C
    		•  The BioGRID Database Seperator Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
    Gene Ontology: [View List]
    Phenotypic Enhancement
    bait Beltrao P (2009) [835]
    Negative Genetic
    bait Hannum G (2009) [496]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSN5
  • KAP142
  • STE21
  • YDR335W
    		•  The BioGRID Database Seperator Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CWC22
  • YGR278W
    		•  The BioGRID Database Seperator Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data
    Gene Ontology: [View List]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE9
  • YGR135W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; the only nonessential 20S subunit
    Gene Ontology: [View List]
    Positive Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD13
  • CWC26
  • YGL174W
    		•  The BioGRID Database Seperator Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TMA23
  • YMR268W-A
  • YMR269W
    		•  The BioGRID Database Seperator Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOT3
  • YIL038C
    		•  The BioGRID Database Seperator Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
    Gene Ontology: [View List]
    Positive Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Suppression
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT3
  • YDR392W
    		•  The BioGRID Database Seperator Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Ingvarsdottir K (2005) [143]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP4
  • RNA4
  • YPR178W
    		•  The BioGRID Database Seperator Splicing factor, component of the U4/U6-U5 snRNP complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC3
  • SWC1
  • YAL011W
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    Negative Genetic
    bait/hit Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HCR1
  • YLR192C
    		•  The BioGRID Database Seperator Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Suppression
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWC5
  • AOR1
  • YBR231C
    		•  The BioGRID Database Seperator Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    Negative Genetic
    hit Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAF9
  • YNL107W
    		•  The BioGRID Database Seperator Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELP3
  • TOT3
  • HPA1
  • YPL086C
    		•  The BioGRID Database Seperator Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
    Gene Ontology: [View List]
    Negative Genetic
    hit Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    hit Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC23
  • YHR166C
    		•  The BioGRID Database Seperator Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Jones AL (2000) [5]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Bauer A (1996) [1]
    bait Novick P (1989) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLC7
  • CID1
  • DIS2
  • YER133W
    		•  The BioGRID Database Seperator Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
    Gene Ontology: [View List]
    Negative Genetic
    hit Wilmes GM (2008) [6467]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS72
  • SWC2
  • YDR485C
    		•  The BioGRID Database Seperator Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Krogan NJ (2003) [712]
    Negative Genetic
    bait Collins SR (2007) [14430]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEX1
  • YNL253W
    		•  The BioGRID Database Seperator Protein involved in mRNA export, component of the transcription export (TREX) complex
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJU2
  • CWC16
  • YKL095W
    		•  The BioGRID Database Seperator Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing
    Gene Ontology: [View List]
    Negative Genetic
    bait Wilmes GM (2008) [6467]
    Phenotypic Enhancement
    bait Beltrao P (2009) [835]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC26
  • HIT3
  • SCD26
  • YFR036W
    		•  The BioGRID Database Seperator Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM1
  • SPB8
  • YJL124C
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
    Gene Ontology: [View List]
    Negative Genetic
    bait Collins SR (2007) [14430]
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASM4
  • NUP59
  • YDL088C
    		•  The BioGRID Database Seperator Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP85
  • RAT9
  • YJR042W
    		•  The BioGRID Database Seperator Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP157
  • YER105C
    		•  The BioGRID Database Seperator Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC, has similarity to Nup170p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP192
  • YJL039C
    		•  The BioGRID Database Seperator Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP57
  • YGR119C
    		•  The BioGRID Database Seperator Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP53
  • YMR153W
    		•  The BioGRID Database Seperator Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAP95
  • RSL1
  • YLR347C
    		•  The BioGRID Database Seperator Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEH1
  • YGL100W
    		•  The BioGRID Database Seperator Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP49
  • NSP49
  • YGL172W
    		•  The BioGRID Database Seperator Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLE1
  • RSS1
  • BRR3
  • YDL207W
    		•  The BioGRID Database Seperator Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC3
  • LEP1
  • YDR159W
    		•  The BioGRID Database Seperator Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP159
  • NUP158
  • RAT7
  • YIL115C
    		•  The BioGRID Database Seperator Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, forms a subcomplex with Nup82p and Nsp1p, required for mRNA export
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP15
  • YMR304W
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that may play a role in ubiquitin precursor processing
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRP1
  • KAP60
  • SCM1
  • YNL189W
    		•  The BioGRID Database Seperator Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THO1
  • YER063W
    		•  The BioGRID Database Seperator Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN9
  • YDR427W
    		•  The BioGRID Database Seperator Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     AKR1
  • YDR264C
    		•  The BioGRID Database Seperator Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHO1
  • SSU81
  • YER118C
    		•  The BioGRID Database Seperator Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
    Gene Ontology: [View List]
    Two-hybrid
    bait Tong AH (2002) [250]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TAF6
  • TAF60
  • YGL112C
    		•  The BioGRID Database Seperator Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Rodriguez-Navarro S (2004) [74]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HPR1
  • TRF1
  • YDR138W
    		•  The BioGRID Database Seperator Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     URN1
  • YPR152C
    		•  The BioGRID Database Seperator Pre-mRNA splicing factor associated with the U2-U5-U6 snRNPs, the RES complex, and the Prp19-associated complex (NTC); null mutation displays synthetic genetic interactions with mutations affecting U2 snRNA and pre-mRNA splicing factors
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLP1
  • YOR250C
    		•  The BioGRID Database Seperator Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAP2
  • YIL034C
    		•  The BioGRID Database Seperator Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC13
  • ANU3
  • YLR208W
    		•  The BioGRID Database Seperator Component of both the Nup84 nuclear pore sub-complex and of the COPII complex (Sar1p, Sec13p, Sec16p, Sec23p, Sec24p, Sec31p, Sfb2p, and Sfb3p) which is important for the formation of ER to Golgi transport vesicles
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YSH1
  • BRR5
  • YLR277C
    		•  The BioGRID Database Seperator Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAs
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YHR127W
  • YHR127W
    		•  The BioGRID Database Seperator Protein of unknown function; localizes to the nucleus
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG17
  • APG17
  • YLR423C
    		•  The BioGRID Database Seperator Scaffold potein responsible for pre-autophagosomal structure organization; interacts with and is required for activation of Apg1p protein kinase; involved in autophagy but not in the Cvt (cytoplasm to vacuole targeting) pathway
    Gene Ontology: [View List]
    Two-hybrid
    hit Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RLR1
  • THO2
  • LDB5
  • ZRG13
  • YNL139C
    		•  The BioGRID Database Seperator Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRK1
  • PAK1
  • YIL095W
    		•  The BioGRID Database Seperator Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
    Gene Ontology: [View List]
    Biochemical Activity
    bait Mok J (2010) [22]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP12
  • YJL197W
    		•  The BioGRID Database Seperator Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Oeffinger M (2007) [375]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF4631
  • YGR162W
    		•  The BioGRID Database Seperator Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIK1
  • NOP56
  • YLR197W
    		•  The BioGRID Database Seperator Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOP1
  • LOT3
  • YDL014W
    		•  The BioGRID Database Seperator Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSA3
  • YLR221C
    		•  The BioGRID Database Seperator Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
    Gene Ontology: [View List]
    Positive Genetic
    bait Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NOP12
  • YOL041C
    		•  The BioGRID Database Seperator Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
    Gene Ontology: [View List]
    Positive Genetic
    hit Wilmes GM (2008) [6467]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC28
  • CDK1
  • SRM5
  • HSL5
  • YBR160W
    		•  The BioGRID Database Seperator Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC66
  • HSS1
  • SEC71
  • YBR171W
    		•  The BioGRID Database Seperator Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
    Gene Ontology: [View List]
    Negative Genetic