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BioGRID | Network Layout for SAC6 for Saccharomyces cerevisiae
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SAC6

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: ABP67, YDR129C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton|Sac6p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SAC6

SAC6 was identified with 33 protein interactions and 68 genetic interactions
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 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Act1p|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Adams AE (1991)
    hit Honts JE (1994)
    Affinity Capture-Western
    hit Sandrock TM (1997)
    bait Karpova TS (1995)
    Co-purification
    bait Holtzman DA (1994)
    Affinity Capture-MS
    hit Gavin AC (2006)
    hit Collins SR (2007)
    Synthetic Growth Defect
    bait/hit Adams AE (1989)
    bait Belmont LD (1998)
    bait Clark MG (2007)
    Synthetic Rescue
    bait/hit Sandrock TM (1999)
    bait/hit Adams AE (1989)
    bait Adams AE (1991)
    bait/hit Adams AE (1989)
    bait Brower SM (1995)
    bait/hit Honts JE (1994)
    Synthetic Lethality
    hit Cheng D (1999)
    Phenotypic Suppression
    bait Cali BM (1998)
    Synthetic Haploinsufficiency
    bait Haarer B (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABP1
  • YCR088W
    		•  The BioGRID Database Seperator Abp1p|Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; protein coding
    Gene Ontology: [View List]
    Co-localization
    bait Huckaba TM (2004)
    Affinity Capture-MS
    bait Collins SR (2007)
    Synthetic Lethality
    bait Adams AE (1993)
    hit Holtzman DA (1993)
    hit Holtzman DA (1994)
    bait Haynes J (2007)
    Synthetic Growth Defect
    hit Goode BL (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SCP1
  • YOR367W
    		•  The BioGRID Database Seperator Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin|Scp1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Goodman A (2003)
    Phenotypic Enhancement
    bait Goodman A (2003)
    bait Gheorghe DM (2008)
    Synthetic Growth Defect
    bait Winder SJ (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CAP2
  • YIL034C
    		•  The BioGRID Database Seperator Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches|Cap2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    Synthetic Lethality
    hit Adams AE (1993)
    hit Karpova TS (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHS5
  • CAL3
  • YLR330W
    		•  The BioGRID Database Seperator Chs5p|Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    Synthetic Lethality
    bait Tong AH (2004)
    bait Lesage G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC40
  • YBR234C
    		•  The BioGRID Database Seperator Arc40p|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; protein coding
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008)
    Synthetic Lethality
    bait Tong AH (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR1
  • DRR1
  • YJR066W
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis|Tor1p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    bait Aronova S (2007)
    Synthetic Lethality
    bait Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BBC1
  • MTI1
  • YJL021C
  • YJL020C
    		•  The BioGRID Database Seperator Bbc1p|Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2001)
    bait Mochida J (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHS3
  • CAL1
  • CSD2
  • DIT101
  • YBR023C
    		•  The BioGRID Database Seperator Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan|Chs3p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Lesage G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHS7
  • YHR142W
    		•  The BioGRID Database Seperator Chs7p|Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Lesage G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA2
  • END4
  • MOP2
  • YNL243W
    		•  The BioGRID Database Seperator Sla2p|Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait/hit Holtzman DA (1994)
    bait/hit Holtzman DA (1993)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKT5
  • CAL2
  • CHS4
  • CSD4
  • YBL061C
    		•  The BioGRID Database Seperator Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation|Skt5p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Lesage G (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MID2
  • KAI1
  • YLR332W
    		•  The BioGRID Database Seperator Mid2p|O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    bait Green R (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRN1
  • YLR429W
    		•  The BioGRID Database Seperator Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity|Crn1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRR1
  • YDR353W
    		•  The BioGRID Database Seperator Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress|Trr1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRV2
  • CAP
  • YNL138W
    		•  The BioGRID Database Seperator CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis|Srv2p; protein coding
    Gene Ontology: [View List]
    PCA
    bait/hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR2
  • DRR2
  • YKL203C
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis|Tor2p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    bait Aronova S (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARC15
  • YIL062C
    		•  The BioGRID Database Seperator Arc15p|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFA1
  • BUF2
  • FUN3
  • RPA1
  • YAR007C
    		•  The BioGRID Database Seperator Rfa1p|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAT4
  • HAL4
  • YCR008W
    		•  The BioGRID Database Seperator Sat4p|Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRP6
  • RNA6
  • TSM7269
  • YBR055C
    		•  The BioGRID Database Seperator Prp6p|Splicing factor, component of the U4/U6-U5 snRNP complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HPR5
  • SRS2
  • YJL092W
    		•  The BioGRID Database Seperator DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination|Srs2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDH1
  • YKL085W
    		•  The BioGRID Database Seperator Mdh1p|Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAA4
  • YMR246W
    		•  The BioGRID Database Seperator Faa4p|Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMT1
  • YDL095W
    		•  The BioGRID Database Seperator Pmt1p|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FPR1
  • FKB1
  • RBP1
  • YNL135C
    		•  The BioGRID Database Seperator Fpr1p|Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Ho Y (2002)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSS51
  • YLR203C
    		•  The BioGRID Database Seperator Mss51p|Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD1
  • LPB9
  • YPL022W
    		•  The BioGRID Database Seperator Rad1p|Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TIF2
  • YJL138C
    		•  The BioGRID Database Seperator Tif2p|Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPK1
  • SLI2
  • YKL126W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK|Ypk1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD23
  • YEL037C
    		•  The BioGRID Database Seperator Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins|Rad23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NUP145
  • RAT10
  • YGL092W
    		•  The BioGRID Database Seperator Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p|Nup145p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD6
  • UBC2
  • YGL058W
    		•  The BioGRID Database Seperator Rad6p|Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p); protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RMD7
  • HUR2
  • GET2
  • YER083C
    		•  The BioGRID Database Seperator Get2p|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TRF4
  • PAP2
  • YOL115W
    		•  The BioGRID Database Seperator Catalytic subunit of TRAMP (Trf4/Pap2p-Mtr4p-Air1p/2p), a nuclear poly (A) polymerase complex involved in RNA quality control; catalyzes polyadenylation of unmodified tRNAs, and snoRNA and rRNA precursors; disputed role as a DNA polymerase|Pap2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MDM39
  • GET1
  • YGL020C
    		•  The BioGRID Database Seperator Get1p|Subunit of the GET complex; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Pan X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator