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BioGRID | Network Layout for BMH2 for Saccharomyces cerevisiae
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BMH2

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: SCD3, YDR099W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 14 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with BMH2

BMH2 was identified with 112 protein interactions and 66 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 BMH1
  • APR6
  • YER177W
    		•  The BioGRID Database Seperator 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Krogan NJ (2006) [7079]
    hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    Affinity Capture-Western
    hit Chaudhri M (2003) [1]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    Synthetic Lethality
    bait Gelperin D (2002) [5]
    bait Gelperin D (1995) [7]
    bait van Heusden GP (2001) [5]
    bait van Heusden GP (1995) [1]
    Synthetic Growth Defect
    hit Lottersberger F (2003) [7]
    bait Dixon SJ (2008) [1412]
    Phenotypic Enhancement
    bait Ichimura T (2004) [1]
    bait Demmel L (2008) [51]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIK1
  • PIK120
  • PIK41
  • YNL267W
    		•  The BioGRID Database Seperator Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait Demmel L (2008) [51]
    Two-hybrid
    bait Demmel L (2008) [51]
    Reconstituted Complex
    hit Demmel L (2008) [51]
    Co-fractionation
    bait Demmel L (2008) [51]
    Affinity Capture-Western
    bait Demmel L (2008) [51]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTH1
  • YDR001C
    		•  The BioGRID Database Seperator Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    bait Collins SR (2007) [9064]
    Affinity Capture-Western
    bait Panni S (2008) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FIN1
  • YDR130C
    		•  The BioGRID Database Seperator Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Mayordomo I (2002) [15]
    bait van Hemert MJ (2003) [4]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    bait van Hemert MJ (2003) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTG2
  • YGL252C
    		•  The BioGRID Database Seperator Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    bait Krogan NJ (2006) [7079]
    bait/hit Gavin AC (2006) [7592]
    hit Collins SR (2007) [9064]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REG1
  • PZF240
  • HEX2
  • SPP43
  • YDR028C
    		•  The BioGRID Database Seperator Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Mayordomo I (2003) [2]
    Affinity Capture-Western
    bait Dombek KM (2004) [5]
    hit Tomas-Cobos L (2005) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KCS1
  • YDR017C
    		•  The BioGRID Database Seperator Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRR1
  • CAT80
  • COT2
  • SDC1
  • YJR090C
    		•  The BioGRID Database Seperator F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
    Gene Ontology: [View List]
    Two-hybrid
    bait Tomas-Cobos L (2005) [5]
    Affinity Capture-Western
    hit Tomas-Cobos L (2005) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDH1
  • HCT1
  • YGL003C
    		•  The BioGRID Database Seperator Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Dial JM (2007) [6]
    bait Hall MC (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLC7
  • CID1
  • DIS2
  • YER133W
    		•  The BioGRID Database Seperator Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    bait Graumann J (2004) [478]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FRQ1
  • YDR373W
    		•  The BioGRID Database Seperator N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Demmel L (2008) [51]
    Affinity Capture-MS
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PSK1
  • FUN31
  • YAL017W
    		•  The BioGRID Database Seperator One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    hit Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LCB2
  • SCS1
  • TSC1
  • YDR062W
    		•  The BioGRID Database Seperator Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002) [3400]
    bait Gavin AC (2006) [7592]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR177W
  • YLR177W
    		•  The BioGRID Database Seperator Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT1
  • SIN2
  • BUR5
  • YBR010W
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Protein-peptide
    bait/hit Walter W (2008) [10]
    Reconstituted Complex
    hit Walter W (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HHT2
  • YNL031C
    		•  The BioGRID Database Seperator One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
    Gene Ontology: [View List]
    Protein-peptide
    bait/hit Walter W (2008) [10]
    Reconstituted Complex
    hit Walter W (2008) [10]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ESA1
  • TAS1
  • YOR244W
    		•  The BioGRID Database Seperator Histone acetyltransferase catalytic subunit of the native multisubunit complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lottersberger F (2007) [12]
    Synthetic Lethality
    bait Lottersberger F (2007) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD53
  • MEC2
  • SPK1
  • LSD1
  • YPL153C
    		•  The BioGRID Database Seperator Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Usui T (2007) [5]
    Dosage Rescue
    bait Usui T (2007) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN4
  • GAL22
  • SDI3
  • RYE1
  • YNL236W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
    Gene Ontology: [View List]
    Synthetic Rescue
    hit van Heusden GP (2001) [5]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK2
  • YNL154C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCK1
  • CKI2
  • YHR135C
    		•  The BioGRID Database Seperator Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGL059W
  • YGL059W
    		•  The BioGRID Database Seperator Protein kinase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAK1
  • YJL141C
    		•  The BioGRID Database Seperator Serine-threonine protein kinase that is part of a glucose-sensing system involved in growth control in response to glucose availability; translocates from the cytoplasm to the nucleus and phosphorylates Pop2p in response to a glucose signal
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Moriya H (2001) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STE20
  • YHL007C
    		•  The BioGRID Database Seperator Signal transducing kinase of the PAK (p21-activated kinase) family, involved in pheromone response and pseudohyphal/invasive growth pathways, activated by Cdc42p; binds Ste4p at a GBB motif present in noncatalytic domains of PAK kinases
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Roberts RL (1997) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CMK1
  • YFR014C
    		•  The BioGRID Database Seperator Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKP1
  • MGO1
  • YDR328C
    		•  The BioGRID Database Seperator Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Tagwerker C (2006) [47]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARK1
  • YNL020C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGL5
  • STC2
  • YOR081C
    		•  The BioGRID Database Seperator Triacylglycerol lipase involved in TAG mobilization; localizes to lipid particles; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SOL1
  • YNR034W
    		•  The BioGRID Database Seperator Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YTA6
  • YPL074W
    		•  The BioGRID Database Seperator Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG11
  • CVT9
  • YPR049C
    		•  The BioGRID Database Seperator Peripheral membrane protein required for delivery of aminopeptidase I (Lap4p) to the vacuole in the cytoplasm-to-vacuole targeting pathway; also required for peroxisomal degradation (pexophagy)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPD3
  • SDI2
  • MOF6
  • REC3
  • YNL330C
    		•  The BioGRID Database Seperator Histone deacetylase; regulates transcription and silencing
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Lottersberger F (2007) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BSP1
  • YPR171W
    		•  The BioGRID Database Seperator Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATG1
  • CVT10
  • APG1
  • AUT3
  • YGL180W
    		•  The BioGRID Database Seperator Protein serine/threonine kinase, required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; forms a complex with Atg13p and Atg17p
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ptacek J (2005) [4183]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ECM13
  • YBL043W
    		•  The BioGRID Database Seperator Non-essential protein of unknown function
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MBF1
  • SUF13
  • YOR298C-A
    		•  The BioGRID Database Seperator Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     APL1
  • YAP80
  • YJR005W
    		•  The BioGRID Database Seperator Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Luo Y (2009) [26]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NAB2
  • YGL122C
    		•  The BioGRID Database Seperator Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Batisse J (2009) [2548]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRR25
  • YPL204W
    		•  The BioGRID Database Seperator Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
    Gene Ontology: [View List]
    Biochemical Activity
    bait Clokie S (2009) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ORC2
  • SIR5
  • RRR1
  • YBR060C
    		•  The BioGRID Database Seperator Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Yahyaoui W (2009) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MCM2
  • YBL023C
    		•  The BioGRID Database Seperator Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Yahyaoui W (2009) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Peng J (2003) [1092]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEK2
  • KHD1
  • YBL032W
    		•  The BioGRID Database Seperator RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
    Gene Ontology: [View List]
    Affinity Capture-RNA
    bait Hasegawa Y (2008) [1095]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSR2
  • MRG19
  • YPR030W
    		•  The BioGRID Database Seperator Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Ho Y (2002) [3666]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BOP3
  • YNL042W
    		•  The BioGRID Database Seperator Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury
    Gene Ontology: [View List]
    Two-hybrid
    hit Uetz P (2000) [875]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NTH2
  • YBR001C
    		•  The BioGRID Database Seperator Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002) [3400]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KKQ8
  • YKL168C
    		•  The BioGRID Database Seperator Putative serine/threonine protein kinase with unknown cellular role
    Gene Ontology: [View List]
    Two-hybrid
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACM1
  • YPL267W
    		•  The BioGRID Database Seperator Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
    Gene Ontology: [View List]
    Two-hybrid
    bait Yu H (2008) [1778]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNR014W
  • YNR014W
    		•  The BioGRID Database Seperator Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SFP1
  • YLR403W
    		•  The BioGRID Database Seperator Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Lempiaeinen H (2009) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SNF1
  • CAT1
  • PAS14
  • HAF3
  • YDR477W
    		•  The BioGRID Database Seperator AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Elbing K (2006) [16]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIC2
  • YDR309C
    		•  The BioGRID Database Seperator Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAS2
  • YMR127C
    		•  The BioGRID Database Seperator Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Shia WJ (2005) [14]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CKS1
  • YBR135W
    		•  The BioGRID Database Seperator Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUD3
  • YCL012W
  • YCL014W
    		•  The BioGRID Database Seperator Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NGR1
  • RBP1
  • YBR212W
    		•  The BioGRID Database Seperator RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BMH2
  • SCD3
  • YDR099W
    		•  The BioGRID Database Seperator 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRE1
  • YER012W
    		•  The BioGRID Database Seperator 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Verma R (2000) [85]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MSB3
  • GYP3
  • YNL293W
    		•  The BioGRID Database Seperator GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR031C
  • YMR031C
    		•  The BioGRID Database Seperator Protein of unknown function with similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; YMR031C is not an essential gene
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPT1
  • YGR123C
    		•  The BioGRID Database Seperator Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS0A
  • YST1
  • NAB1
  • YGR214W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN2
  • YPL256C
    		•  The BioGRID Database Seperator G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Archambault V (2004) [74]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRE1
  • YCL051W
    		•  The BioGRID Database Seperator Protein involved in control of cell wall structure and stress response; inhibits Cbk1p protein kinase activity; overproduction confers resistance to cell-wall degrading enzymes
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNR047W
  • YNR047W
    		•  The BioGRID Database Seperator Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REG2
  • YBR050C
    		•  The BioGRID Database Seperator Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBP11
  • YKR098C
    		•  The BioGRID Database Seperator Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PRK1
  • PAK1
  • YIL095W
    		•  The BioGRID Database Seperator Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLX4
  • YLR135W
    		•  The BioGRID Database Seperator Subunit of a complex, with Slx1p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YLR345W
  • YLR345W
    		•  The BioGRID Database Seperator Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIS4
  • YML006C
    		•  The BioGRID Database Seperator CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC31
  • DSK1
  • YOR257W
    		•  The BioGRID Database Seperator Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; interacts with Kar1p
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YAP1801
  • YHR161C
    		•  The BioGRID Database Seperator Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RFX1
  • CRT1
  • YLR176C
    		•  The BioGRID Database Seperator Protein involved in DNA damage and replication checkpoint pathway; recruits repressors Tup1p and Cyc8p to promoters of DNA damage-inducible genes; similar to a family of mammalian DNA binding RFX1-4 proteins
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR348C
  • YDR348C
    		•  The BioGRID Database Seperator Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PKH1
  • YDR490C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ASK10
  • YGR097W
    		•  The BioGRID Database Seperator Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GCR2
  • YNL199C
    		•  The BioGRID Database Seperator Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
    Gene Ontology: [View List]
    Two-hybrid
    hit Mayordomo I (2002) [15]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MIG1
  • TDS22
  • SSN1
  • CAT4
  • YGL035C
    		•  The BioGRID Database Seperator Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAL83
  • SPM1
  • YER027C
    		•  The BioGRID Database Seperator One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006) [7079]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEP1
  • YNL128W
    		•  The BioGRID Database Seperator Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ADO1
  • YJR105W
    		•  The BioGRID Database Seperator Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIW14
  • OCA3
  • YNL032W
    		•  The BioGRID Database Seperator Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THR1
  • YHR025W
    		•  The BioGRID Database Seperator Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLA4
  • ERC10
  • YNL298W
    		•  The BioGRID Database Seperator Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
    Gene Ontology: [View List]
    Positive Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC13
  • EST4
  • YDL220C
    		•  The BioGRID Database Seperator Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
    Gene Ontology: [View List]
    Synthetic Rescue
    bait Addinall SG (2008) [386]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM4
  • PFD2
  • YEL003W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DBF2
  • YGR092W
    		•  The BioGRID Database Seperator Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ELM1
  • LDB9
  • YKL048C
    		•  The BioGRID Database Seperator Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CTK1
  • YKL139W
    		•  The BioGRID Database Seperator Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GIM5
  • PFD5
  • YML094W
    		•  The BioGRID Database Seperator Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRS4
  • YDR439W
    		•  The BioGRID Database Seperator Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HOM6
  • YJR139C
    		•  The BioGRID Database Seperator Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YJR120W
  • YJR120W
    		•  The BioGRID Database Seperator Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSE2
  • MED9
  • YNR010W
    		•  The BioGRID Database Seperator Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BUB3
  • YOR026W
    		•  The BioGRID Database Seperator Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PPH3
  • YDR075W
    		•  The BioGRID Database Seperator Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     THG1
  • YGR024C
    		•  The BioGRID Database Seperator tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MPS1
  • RPK1
  • YDL028C
    		•  The BioGRID Database Seperator Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     STU1
  • YBL034C
    		•  The BioGRID Database Seperator Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLA1
  • YBL007C
    		•  The BioGRID Database Seperator Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SLM4
  • EGO3
  • GSE1
  • NIR1
  • YBR077C
    		•  The BioGRID Database Seperator Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM1
  • YCR086W
    		•  The BioGRID Database Seperator Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC24
  • CLS4
  • YAL041W
    		•  The BioGRID Database Seperator Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
    Gene Ontology: [View List]
    Negative Genetic
    bait Costanzo M (2010) [68487]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARF1
  • YDL192W
    		•  The BioGRID Database Seperator ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC25
  • CTN1
  • YLR310C
    		•  The BioGRID Database Seperator Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
    Gene Ontology: [View List]
    Dosage Rescue
    bait Gelperin D (1995) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNG2
  • EAF4
  • NBN1
  • YHR090C
    		•  The BioGRID Database Seperator Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Lottersberger F (2007) [12]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC21
  • YNL287W
    		•  The BioGRID Database Seperator Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC23
  • YPR181C
    		•  The BioGRID Database Seperator GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS1
  • GRD1
  • LAM1
  • VPL1
  • YKR001C
    		•  The BioGRID Database Seperator Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPK1
  • SRA3
  • PKA1
  • YJL164C
    		•  The BioGRID Database Seperator cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
    Gene Ontology: [View List]
    Dosage Rescue
    hit Gelperin D (1995) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CHC1
  • SWA5
  • YGL206C
    		•  The BioGRID Database Seperator Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
    Gene Ontology: [View List]
    Dosage Rescue
    bait Gelperin D (1995) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GLN3
  • YER040W
    		•  The BioGRID Database Seperator Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
    Gene Ontology: [View List]
    Dosage Rescue
    bait Schmelzle T (2004) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GAT1
  • MEP80
  • NIL1
  • YFL021W
    		•  The BioGRID Database Seperator Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
    Gene Ontology: [View List]
    Dosage Rescue
    bait Schmelzle T (2004) [11]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPK1
  • SLI2
  • YKL126W
    		•  The BioGRID Database Seperator Serine/threonine protein kinase required for receptor-mediated endocytosis; involved in sphingolipid-mediated and cell integrity signaling pathways; localized to the bud neck, cytosol and plasma membrane; homolog of mammalian kinase SGK
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Gelperin D (2002) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTG3
  • YBL103C
    		•  The BioGRID Database Seperator Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
    Gene Ontology: [View List]
    Synthetic Rescue
    hit van Heusden GP (2001) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT31
  • YPT8
  • YER031C
    		•  The BioGRID Database Seperator GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC14
  • PIT1
  • YMR079W
    		•  The BioGRID Database Seperator Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC18
  • ANU4
  • YBR080C
    		•  The BioGRID Database Seperator ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF
    Gene Ontology: [View List]
    Dosage Rescue
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MYO2
  • CDC66
  • YOR326W
    		•  The BioGRID Database Seperator One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OCA6
  • YDR067C
    		•  The BioGRID Database Seperator Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
    Gene Ontology: [View List]
    Negative Genetic
    hit Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIT4
  • LGN4
  • YDL047W
    		•  The BioGRID Database Seperator Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     IPT1
  • KTI6
  • SYR4
  • YDR072C
    		•  The BioGRID Database Seperator Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ACT1
  • ABY1
  • END7
  • YFL039C
    		•  The BioGRID Database Seperator Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC15
  • YGL233W
    		•  The BioGRID Database Seperator Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC1
  • YDR164C
    		•  The BioGRID Database Seperator Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC2
  • YNL272C
    		•  The BioGRID Database Seperator Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC3
  • PSL1
  • YER008C
    		•  The BioGRID Database Seperator Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC4
  • SRO6
  • YFL005W
    		•  The BioGRID Database Seperator Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
    Gene Ontology: [View List]
    Dosage Growth Defect
    bait Demmel L (2008) [51]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TPS2
  • PFK3
  • HOG2
  • YDR074W
    		•  The BioGRID Database Seperator Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
    Gene Ontology: [View List]
    Negative Genetic
    bait Fiedler D (2009) [4053]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.