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BioGRID | Network Layout for SSS1 for Saccharomyces cerevisiae
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SSS1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YDR086C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Sss1p|Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p; protein coding
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PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 10 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with SSS1

SSS1 was identified with 19 protein interactions and 8 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SEC61
  • YLR378C
    		•  The BioGRID Database Seperator Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER|Sec61p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Wilkinson BM (1997)
    Co-fractionation
    hit Esnault Y (1994)
    Co-purification
    bait Morrow MW (2001)
    Dosage Rescue
    bait Wilkinson BM (1997)
    bait Esnault Y (1993)
    bait Esnault Y (1994)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     WBP1
  • YEL002C
    		•  The BioGRID Database Seperator Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum|Wbp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Scheper W (2003)
    Two-hybrid
    bait Scheper W (2003)
    hit Chavan M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWP1
  • YMR149W
    		•  The BioGRID Database Seperator Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum|Swp1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Scheper W (2003)
    Two-hybrid
    hit Chavan M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SBH1
  • SEB1
  • YER087C-A
  • YER087C-B
    		•  The BioGRID Database Seperator Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p|Sbh1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Panzner S (1995)
    bait Feng D (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • CIM5
  • YTA3
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Ng W (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEC3
  • PIP3
  • YLR288C
    		•  The BioGRID Database Seperator DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1|Mec3p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERG1
  • YGR175C
    		•  The BioGRID Database Seperator Erg1p|Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1|Sic1p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ERP2
  • YAL007C
    		•  The BioGRID Database Seperator Erp2p|Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC63
  • PTL1
  • YOR254C
    		•  The BioGRID Database Seperator Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER|Sec63p; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait Matlack KE (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GUP2
  • YPL189W
    		•  The BioGRID Database Seperator Gup2p|Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Miller JP (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST1
  • NLT1
  • YJL002C
    		•  The BioGRID Database Seperator Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins|Ost1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Chavan M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OST4
  • YDL232W
    		•  The BioGRID Database Seperator Ost4p|Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Chavan M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC5
  • YDR166C
    		•  The BioGRID Database Seperator Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Sec5p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Toikkanen JH (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC3
  • PSL1
  • YER008C
    		•  The BioGRID Database Seperator Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion|Sec3p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Toikkanen JH (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PIM1
  • LON1
  • YBL022C
    		•  The BioGRID Database Seperator ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria|Pim1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait van Dyck L (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC8
  • YPR055W
    		•  The BioGRID Database Seperator Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Sec8p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Toikkanen JH (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC15
  • YGL233W
    		•  The BioGRID Database Seperator Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles|Sec15p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Toikkanen JH (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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