The BioGRID Database Seperator
Search
Organism:

BioGRID | Network Layout for STN1 for Saccharomyces cerevisiae
[JPG] [PNG] [SVG]		 The BioGRID Database Seperator

STN1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YDR082W
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [UniprotKB] | [SGD] | [Entrez Gene] | [GeneDB]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 7 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with STN1

STN1 was identified with 31 protein interactions and 27 genetic interactions
 Name Aliases The BioGRID Database Seperator Description
Evidence Code
Role Source [Interactions]
The BioGRID Database Seperator
 CDC13
  • EST4
  • YDL220C
    		•  The BioGRID Database Seperator Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000) [875]
    bait Chandra A (2001) [3]
    bait/hit Grandin N (2001) [8]
    bait/hit Grandin N (2001) [4]
    bait/hit Grandin N (1997) [3]
    bait Wang MJ (2000) [1]
    hit Petreaca RC (2006) [3]
    hit Lin YC (2007) [1]
    hit Petreaca RC (2007) [9]
    bait Yu H (2008) [1778]
    bait Puglisi A (2008) [6]
    hit Puglisi A (2008) [7]
    Affinity Capture-Western
    bait Qian W (2009) [6]
    bait Li S (2009) [8]
    Dosage Lethality
    bait Grandin N (2000) [5]
    Dosage Rescue
    bait Chandra A (2001) [3]
    Synthetic Lethality
    hit Grandin N (1997) [3]
    Phenotypic Enhancement
    bait Li S (2009) [8]
    Phenotypic Suppression
    bait Li S (2009) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEN1
  • YLR010C
    		•  The BioGRID Database Seperator Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Grandin N (2001) [8]
    hit Gao H (2007) [1]
    bait Qian W (2009) [6]
    Two-hybrid
    bait Grandin N (2001) [8]
    hit Petreaca RC (2006) [3]
    hit Petreaca RC (2007) [9]
    bait Yu H (2008) [1778]
    bait Puglisi A (2008) [6]
    hit Puglisi A (2008) [7]
    bait Xu L (2009) [7]
    Dosage Rescue
    hit Grandin N (2001) [8]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL12
  • YBL035C
    		•  The BioGRID Database Seperator B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
    Gene Ontology: [View List]
    Two-hybrid
    bait Grossi S (2004) [3]
    bait Puglisi A (2008) [6]
    hit Puglisi A (2008) [7]
    Affinity Capture-Western
    bait Grossi S (2004) [3]
    Reconstituted Complex
    hit Petreaca RC (2006) [3]
    Synthetic Lethality
    hit Grossi S (2004) [3]
    Synthetic Rescue
    hit Gasparyan HJ (2009) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EST2
  • YLR318W
    		•  The BioGRID Database Seperator Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
    Gene Ontology: [View List]
    Dosage Rescue
    bait Enomoto S (2004) [5]
    Phenotypic Enhancement
    bait Dahlseid JN (2003) [1]
    hit Petreaca RC (2007) [9]
    Synthetic Lethality
    hit Petreaca RC (2007) [9]
    Synthetic Growth Defect
    hit Petreaca RC (2007) [9]
    hit Puglisi A (2008) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD50
  • YNL250W
    		•  The BioGRID Database Seperator Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Puglisi A (2008) [6]
    Phenotypic Enhancement
    hit Puglisi A (2008) [7]
    Synthetic Growth Defect
    hit Puglisi A (2008) [6]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEL1
  • YBL088C
    		•  The BioGRID Database Seperator Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait Puglisi A (2008) [6]
    Phenotypic Enhancement
    hit Puglisi A (2008) [7]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD52
  • YML032C
    		•  The BioGRID Database Seperator Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Petreaca RC (2007) [9]
    Phenotypic Enhancement
    hit Petreaca RC (2007) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD9
  • YDR217C
    		•  The BioGRID Database Seperator DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Petreaca RC (2007) [9]
    Synthetic Growth Defect
    bait Gasparyan HJ (2009) [2]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM4
  • SDB23
  • USS1
  • YER112W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
    Gene Ontology: [View List]
    Two-hybrid
    bait Fromont-Racine M (2000) [266]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSM1
  • YCR086W
    		•  The BioGRID Database Seperator Nucleolar protein that forms a complex with Lrs4p which binds Mam1p at kinetochores during meiosis I to mediate accurate chromosome segregation, may be involved in premeiotic DNA replication; possible role in telomere maintenance
    Gene Ontology: [View List]
    Two-hybrid
    bait Wong J (2007) [604]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSC82
  • HSP90
  • YMR186W
    		•  The BioGRID Database Seperator Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
    Gene Ontology: [View List]
    Dosage Rescue
    hit Grandin N (2001) [4]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL1
  • HPR3
  • CDC17
  • CRT5
  • YNL102W
    		•  The BioGRID Database Seperator Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
    Gene Ontology: [View List]
    Dosage Rescue
    bait Chandra A (2001) [3]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD24
  • YER173W
    		•  The BioGRID Database Seperator Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
    Gene Ontology: [View List]
    Synthetic Lethality
    hit Petreaca RC (2007) [9]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TGS1
  • YPL157W
    		•  The BioGRID Database Seperator Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology
    Gene Ontology: [View List]
    Phenotypic Enhancement
    hit Franke J (2008) [5]
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    terms and conditions - privacy policy - Osprey Network Visualization System
    BioGRID: A General Repository for Interaction Datasets.
    Chris Stark, Bobby-Joe Breitkreutz, Teresa Reguly, Lorrie Boucher, Ashton Breitkreutz, Mike Tyers.
    Nucleic Acids Res. Jan 1;34:D535-9.