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BioGRID | Network Layout for CDC34 for Saccharomyces cerevisiae
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CDC34

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: DNA6, UBC3, YDR054C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Cdc34p|Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 14 total GO mappings for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CDC34

CDC34 was identified with 60 protein interactions and 65 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 CDC53
  • YDL132W
    		•  The BioGRID Database Seperator Cdc53p|Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Patton EE (1998)
    bait Skowyra D (1997)
    bait Skowyra D (1999)
    bait Willems AR (1996)
    hit Mathias N (1998)
    hit Mathias N (1996)
    bait Kurz T (2008)
    Reconstituted Complex
    hit Feldman RM (1997)
    Affinity Capture-MS
    bait Willems AR (1999)
    hit Krogan NJ (2006)
    bait Collins SR (2007)
    Co-fractionation
    hit Mathias N (1998)
    Dosage Rescue
    bait Kaiser P (1998)
    bait/hit Mathias N (1996)
    Synthetic Lethality
    bait Kurz T (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIC1
  • SDB25
  • YLR079W
    		•  The BioGRID Database Seperator Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1|Sic1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Verma R (1997)
    hit Verma R (1997)
    Biochemical Activity
    hit Feldman RM (1997)
    hit Skowyra D (1997)
    hit Verma R (1997)
    hit Verma R (1997)
    Synthetic Growth Defect
    bait Varelas X (2006)
    Phenotypic Suppression
    hit Coccetti P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC4
  • YFL009W
    		•  The BioGRID Database Seperator Cdc4p|F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Mathias N (1998)
    hit Mathias N (1996)
    Reconstituted Complex
    bait Feldman RM (1997)
    Co-fractionation
    hit Mathias N (1998)
    Synthetic Lethality
    bait Mathias N (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC34
  • DNA6
  • UBC3
  • YDR054C
    		•  The BioGRID Database Seperator Cdc34p|Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Varelas X (2003)
    hit Ptak C (1994)
    Biochemical Activity
    hit Banerjee A (1993)
    hit Scaglione KM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MET30
  • ZRG11
  • YIL046W
    		•  The BioGRID Database Seperator F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus|Met30p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Kaiser P (1998)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Dosage Lethality
    hit Patton EE (1998)
    Dosage Rescue
    bait Kaiser P (1998)
    Synthetic Lethality
    hit Kaiser P (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SKP1
  • MGO1
  • YDR328C
    		•  The BioGRID Database Seperator Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase|Skp1p; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    hit Feldman RM (1997)
    Affinity Capture-Western
    hit Patton EE (1998)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRT1
  • HRT2
  • RBX1
  • ROC1
  • YOL133W
    		•  The BioGRID Database Seperator Hrt1p|RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Seol JH (1999)
    Dosage Rescue
    bait Blondel M (2000)
    Synthetic Lethality
    hit Blondel M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GRR1
  • CAT80
  • COT2
  • SSU2
  • YJR090C
    		•  The BioGRID Database Seperator F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification|Grr1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    Dosage Lethality
    hit Patton EE (1998)
    Synthetic Rescue
    hit Kishi T (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SWE1
  • WEE1
  • YJL187C
    		•  The BioGRID Database Seperator Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate|Swe1p; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Kaiser P (1998)
    bait Ptacek J (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTG2
  • YGL252C
    		•  The BioGRID Database Seperator Rtg2p|Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RTT101
  • CUL8
  • YJL047C
    		•  The BioGRID Database Seperator Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; deletion phenotype suggests a role in anaphase progression; interacts with Mms22p and implicated in Mms22-dependent DNA repair; modified by the ubiquitin-like protein, Rub1p|Rtt101p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBS1
  • YBR165W
    		•  The BioGRID Database Seperator Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity|Ubs1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Baumer M (2000)
    hit Prendergast JA (1996)
    Synthetic Lethality
    bait Prendergast JA (1996)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     QRI8
  • UBC7
  • YMR022W
    		•  The BioGRID Database Seperator Ubc7p|Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    hit Arnason TG (2005)
    Dosage Rescue
    hit Arnason TG (2005)
    Phenotypic Enhancement
    hit Arnason TG (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RSP5
  • MDP1
  • MUT2
  • NPI1
  • YER125W
    		•  The BioGRID Database Seperator Rsp5p|Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain; protein coding
    Gene Ontology: [View List]
    Phenotypic Suppression
    bait/hit Arnason TG (2005)
    Dosage Growth Defect
    bait Arnason TG (2005)
    Phenotypic Enhancement
    bait Hiraishi H (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LRG1
  • YDL240W
    		•  The BioGRID Database Seperator Lrg1p|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    hit Varelas X (2006)
    Synthetic Rescue
    hit Varelas X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAS2
  • CTN5
  • CYR3
  • GLC5
  • YNL098C
    		•  The BioGRID Database Seperator GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes|Ras2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Bidlingmaier S (2002)
    bait Irniger S (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ABD1
  • YBR236C
    		•  The BioGRID Database Seperator Abd1p|Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Schwer B (2000)
    Phenotypic Enhancement
    hit Schwer B (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPA2
  • FUS6
  • PEA1
  • YLL021W
    		•  The BioGRID Database Seperator Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate|Spa2p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Bidlingmaier S (2002)
    Synthetic Rescue
    hit Sheu YJ (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAC7
  • YDR389W
    		•  The BioGRID Database Seperator GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate|Sac7p; protein coding
    Gene Ontology: [View List]
    Dosage Lethality
    hit Varelas X (2006)
    Synthetic Growth Defect
    hit Varelas X (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POL12
  • YBL035C
    		•  The BioGRID Database Seperator B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation|Pol12p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC9
  • MMS8
  • YDL164C
    		•  The BioGRID Database Seperator Cdc9p|DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CSNK2A1
  • CK2A1
  • CKII
  • CKII alpha
  • EG1457
    		•  The BioGRID Database Seperator CK2 catalytic subunit alpha|casein kinase II alpha 1 subunit|casein kinase II alpha subunit|casein kinase II-alpha subunit|protein kinase CK2; casein kinase 2, alpha 1 polypeptide
    Gene Ontology: [View List]
    Biochemical Activity
    bait Coccetti P (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MMS1
  • RTT108
  • SLM6
  • YPR164W
    		•  The BioGRID Database Seperator Mms1p|Protein likely involved in protection against replication-dependent DNA damage; mutants are sensitive to methyl methanesulfonate (MMS); implicated in regulation of Ty1 transposition; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SIN4
  • BEL2
  • GAL22
  • MED16
  • YNL236W
    		•  The BioGRID Database Seperator Sin4p|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Uetz P (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HEX3
  • SLX5
  • YDL013W
    		•  The BioGRID Database Seperator Slx5p|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate; protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    bait Ii T (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MEP3
  • YPR138C
    		•  The BioGRID Database Seperator Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease|Mep3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN2
  • YPL256C
    		•  The BioGRID Database Seperator Cln2p|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); protein coding
    Gene Ontology: [View List]
    Biochemical Activity
    hit Deshaies RJ (1995)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GDH2
  • YDL215C
    		•  The BioGRID Database Seperator Gdh2p|NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YBR280C
  • SAF1
    		•  The BioGRID Database Seperator F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1|Saf1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ETR1
  • MRF1
  • YBR026C
    		•  The BioGRID Database Seperator 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis|Etr1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DRS2
  • FUN38
  • SWA3
  • YAL026C
    		•  The BioGRID Database Seperator Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease|Drs2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC6
  • YJL194W
    		•  The BioGRID Database Seperator Cdc6p|Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; protein coding
    Gene Ontology: [View List]