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BioGRID | Network Layout for PSA1 for Saccharomyces cerevisiae
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PSA1

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: MPG1, SRB1, VIG9, YDL055C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure|Psa1p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 5 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with PSA1

PSA1 was identified with 84 protein interactions and 5 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    Two-hybrid
    bait Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ALG1
  • YBR110W
    		•  The BioGRID Database Seperator Alg1p|Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait Janik A (2003)
    bait Shimma Y (1997)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL2A
  • RPL5B
  • YFR031C-A
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins|Rpl2ap; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL28
  • CYH2
  • YGL103W
    		•  The BioGRID Database Seperator Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance|Rpl28p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL10
  • GRC5
  • QSR1
  • YLR075W
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family|Rpl10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL7A
  • YGL076C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)|Rpl7ap; ncRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL13B
  • YMR142C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein|Rpl13bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RRP5
  • YMR229C
    		•  The BioGRID Database Seperator Protein required for the synthesis of both 18S and 5.8S rRNA; C-terminal region is crucial for the formation of 18S rRNA and N-terminal region is required for the 5.8S rRNA; component of small ribosomal subunit (SSU) processosome|Rrp5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC7
  • YDR170C
    		•  The BioGRID Database Seperator Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles|Sec7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TUB2
  • ARM10
  • SHE8
  • YFL037W
    		•  The BioGRID Database Seperator Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules|Tub2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NEW1
  • YPL226W
    		•  The BioGRID Database Seperator ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein|New1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL8B
  • KRB1
  • SCL41
  • YLL045C
    		•  The BioGRID Database Seperator Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits|Rpl8bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPT1
  • CIM5
  • YTA3
  • YKL145W
    		•  The BioGRID Database Seperator One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p|Rpt1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     POR1
  • OMP2
  • YNL055C
    		•  The BioGRID Database Seperator Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated|Por1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SAM1
  • ETH10
  • YLR180W
    		•  The BioGRID Database Seperator S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)|Sam1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CRM1
  • KAP124
  • XPO1
  • YGR218W
    		•  The BioGRID Database Seperator Crm1p|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCT8
  • YJL008C
    		•  The BioGRID Database Seperator Cct8p|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CDC19
  • PYK1
  • YAL038W
    		•  The BioGRID Database Seperator Cdc19p|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAM33
  • YIL070C
    		•  The BioGRID Database Seperator Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R|Mam33p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS24B
  • RPS24EB
  • YIL069C
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein|Rps24bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPS0B
  • YST2
  • YLR048W
    		•  The BioGRID Database Seperator Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal|Rps0bp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMC3
  • YJL074C
    		•  The BioGRID Database Seperator Smc3p|Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BNI1
  • PPF3
  • SHE5
  • YNL271C
    		•  The BioGRID Database Seperator Bni1p|Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TSR2
  • YLR435W
    		•  The BioGRID Database Seperator Protein with a potential role in pre-rRNA processing|Tsr2p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YGR130C
  • YGR130C
    		•  The BioGRID Database Seperator Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)|Ygr130cp; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SRO9
  • YCL037C
    		•  The BioGRID Database Seperator Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif|Sro9p; protein coding
    Gene Ontology: [View List]
    PCA
    bait Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MAL13
  • YGR288W
    		•  The BioGRID Database Seperator MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C|Mal13p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC26
  • YDR238C
    		•  The BioGRID Database Seperator Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)|Sec26p; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     EFT2
  • YDR385W
    		•  The BioGRID Database Seperator Eft2p|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ATX1
  • YNL259C
    		•  The BioGRID Database Seperator Atx1p|Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL045W
  • YNL045W
    		•  The BioGRID Database Seperator Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus|Ynl045wp; protein coding
    Gene Ontology: [View List]
    PCA
    hit Tarassov K (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPN10
  • MCB1
  • SUN1
  • YHR200W
    		•  The BioGRID Database Seperator Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein|Rpn10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Seong KM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YCF1
  • YDR135C
    		•  The BioGRID Database Seperator Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR|Ycf1p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Paumi CM (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPA135
  • RPA2
  • RRN2
  • SRP3
  • YPR010C
    		•  The BioGRID Database Seperator RNA polymerase I subunit A135|Rpa135p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     GUS1
  • GSN1
  • YGL245W
    		•  The BioGRID Database Seperator Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm|Gus1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLB2
  • YPR119W
    		•  The BioGRID Database Seperator B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome|Clb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Honey S (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAD51
  • MUT5
  • YER095W
    		•  The BioGRID Database Seperator Rad51p|Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC27
  • YGL137W
    		•  The BioGRID Database Seperator Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP|Sec27p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YNL149C
  • PGA2
    		•  The BioGRID Database Seperator Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect|Pga2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEC10
  • YLR166C
    		•  The BioGRID Database Seperator Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis|Sec10p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit De Craene JO (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TEF4
  • EFC1
  • YKL081W
    		•  The BioGRID Database Seperator Tef4p|Translation elongation factor EF-1 gamma; ncRNA
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LYS12
  • LYS10
  • LYS11
  • YIL094C
    		•  The BioGRID Database Seperator Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate|Lys12p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     KAP122
  • PDR6
  • YGL016W
    		•  The BioGRID Database Seperator Kap122p|Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RVB2
  • TIH2
  • TIP49
  • TIP49B
  • YPL235W
    		•  The BioGRID Database Seperator Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family|Rvb2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RPL18A
  • RP28A
  • YOL120C
    		•  The BioGRID Database Seperator Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation|Rpl18ap; protein coding
    Gene Ontology: [View List]