| Name |
Aliases |
 |
Description |
| Evidence Code |
| Role |
Source [Interactions] |
|
|
|
| GCN5 |
SWI9ADA4YGR252W |
|
Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
|
|
|
|
|
| RTT102 |
YGR275W |
|
Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition
|
|
|
|
|
| NAB2 |
YGL122C |
|
Nuclear polyadenylated RNA-binding protein; autoregulates mRNA levels; related to human hnRNPs; has nuclear localization signal sequence that binds to Kap104p; required for poly(A) tail length control and nuclear mRNA export
|
|
|
|
|
| LTE1 |
MSI2YAL024C |
|
Putative GDP/GTP exchange factor required for mitotic exit at low temperatures; acts as a guanine nucleotide exchange factor (GEF) for Tem1p, which is a key regulator of mitotic exit; physically associates with Ras2p-GTP
|
|
|
|
|
| PHO4 |
YFR034C |
|
Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
|
|
|
|
|
| RPN11 |
MPR1YFR004W |
|
Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates
|
|
|
|
|
| SRP101 |
YDR292C |
|
Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
|
|
|
|
|
| GCN2 |
AAS1YDR283C |
|
Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex
|
|
|
|
|
| DAL81 |
UGA35YIR023W |
|
Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
|
|
|
|
|
| SUR1 |
LPE15CSG1BCL21YPL057C |
|
Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p
|
|
|
|
|
| POB3 |
YML069W |
|
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
|
|
|
|
|
| SEC63 |
PTL1YOR254C |
|
Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
|
|
|
|
|
| ARP8 |
YOR141C |
|
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
|
|
|
|
|
| ALG9 |
YNL219C |
|
Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
|
|
|
|
|
| DOM34 |
YNL001W |
|
Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota
|
|
|
|
|
| SEC61 |
YLR378C |
|
Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
|
|
|
|
|
| YHC1 |
YLR298C |
|
Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
|
|
|
|
|
| HBS1 |
YKR084C |
|
GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components
|
|
|
|
|
| SEM1 |
DSS1HOD1YDR363W-A |
|
Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
|
|
|
|
|
| UBR1 |
PTR1YGR184C |
|
Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
|
|
|
|
|
| KTR3 |
YBR205W |
|
Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
|
|
|
|
|
| POP2 |
CAF1YNR052C |
|
RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
|
|
|
|
|
| CCR4 |
FUN27NUT21YAL021C |
|
Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
|
|
|
|
|
| SMI1 |
KNR4YGR229C |
|
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
|
|
|
|
|
| YOR1 |
YRS1YGR281W |
|
Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
|
|
|
|
|
| YLR152C |
YLR152C |
|
Putative protein of unknown function; YLR152C is not an essential gene
|
|
|
|
|
| MMM1 |
YME6YLL006W |
|
Mitochondrial outer membrane protein, component of the Mdm10-Mdm12-Mmm1 complex involved in import and assembly of outer membrane beta-barrel proteins
|
|
|
|
|
| HAL5 |
YJL165C |
|
Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters
|
|
|
|
|
| BGL2 |
YGR282C |
|
Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
|
|
|
|
|
| RPS29A |
YLR388W |
|
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
|
|
|
|
|
