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BioGRID | Network Layout for VAM6 for Saccharomyces cerevisiae
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VAM6

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: CVT4, VPL18, VPL22, VPS39, YDL077C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p|Vam6p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 8 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with VAM6

VAM6 was identified with 49 protein interactions and 10 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 VPS41
  • CVT8
  • FET2
  • SVL2
  • YDR080W
    		•  The BioGRID Database Seperator Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport|Vps41p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Gavin AC (2006)
    hit Collins SR (2007)
    bait Peplowska K (2007)
    Affinity Capture-Western
    bait/hit Seals DF (2000)
    bait Price A (2000)
    hit Nakamura N (1997)
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP5
  • END1
  • VAM1
  • VPL9
  • YMR231W
    		•  The BioGRID Database Seperator Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p|Pep5p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Seals DF (2000)
    hit Wurmser AE (2000)
    Two-hybrid
    bait Wurmser AE (2000)
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS33
  • CLS14
  • MET27
  • PEP14
  • YLR396C
    		•  The BioGRID Database Seperator ATP-binding protein that is a subunit of the HOPS complex and the CORVET tethering complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport|Vps33p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Seals DF (2000)
    Affinity Capture-MS
    bait Gavin AC (2006)
    bait Stroupe C (2006)
    hit Collins SR (2007)
    Co-purification
    bait/hit Collins KM (2005)
    Reconstituted Complex
    bait Starai VJ (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VPS16
  • SVL6
  • VAM9
  • VPT16
  • YPL045W
    		•  The BioGRID Database Seperator Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages|Vps16p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Seals DF (2000)
    bait Wang CW (2003)
    Affinity Capture-MS
    bait Gavin AC (2006)
    hit Collins SR (2007)
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT7
  • AST4
  • VAM4
  • YML001W
    		•  The BioGRID Database Seperator GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7|Ypt7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Price A (2000)
    bait Seals DF (2000)
    Reconstituted Complex
    hit Wurmser AE (2000)
    Two-hybrid
    hit Wurmser AE (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM7
  • VPS43
  • YGL212W
    		•  The BioGRID Database Seperator Component of the vacuole SNARE complex involved in vacuolar morphogenesis; SNAP-25 homolog; functions with a syntaxin homolog Vam3p in vacuolar protein trafficking|Vam7p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Collins KM (2005)
    bait Stroupe C (2006)
    Co-purification
    bait/hit Collins KM (2005)
    Reconstituted Complex
    bait Jun Y (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PEP3
  • VAM8
  • VPS18
  • VPT18
  • YLR148W
    		•  The BioGRID Database Seperator Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis|Pep3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Seals DF (2000)
    Co-purification
    bait/hit Collins KM (2005)
    Affinity Capture-MS
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VTI1
  • YMR197C
    		•  The BioGRID Database Seperator Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways|Vti1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Collins KM (2005)
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM3
  • PTH1
  • YOR106W
    		•  The BioGRID Database Seperator Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins|Vam3p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Collins KM (2005)
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HSP82
  • HSP90
  • YPL240C
    		•  The BioGRID Database Seperator Hsp82p|Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Zhao R (2005)
    Synthetic Growth Defect
    bait/hit McClellan AJ (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     NYV1
  • MAM2
  • YLR093C
    		•  The BioGRID Database Seperator Nyv1p|v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YKT6
  • YKL196C
    		•  The BioGRID Database Seperator Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus|Ykt6p; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YOR051C
  • YOR29-02
    		•  The BioGRID Database Seperator Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts|Yor051cp; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     VAM6
  • CVT4
  • VPL18
  • VPL22
  • YDL077C
    		•  The BioGRID Database Seperator Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p|Vam6p; protein coding
    Gene Ontology: [View List]
    Co-purification
    bait/hit Collins KM (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BEM1
  • SRO1
  • YBR200W
    		•  The BioGRID Database Seperator Bem1p|Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p; protein coding
    Gene Ontology: [View List]
    Co-fractionation
    bait Xu H (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CCZ1
  • CVT16
  • YBR131W
    		•  The BioGRID Database Seperator Ccz1p|Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Wang CW (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MON1
  • AUT12
  • YGL124C
    		•  The BioGRID Database Seperator Mon1p|Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Wang CW (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     LSM7
  • YNL147W
    		•  The BioGRID Database Seperator Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA|Lsm7p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait Fromont-Racine M (2000)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YMR1
  • YJR110W
    		•  The BioGRID Database Seperator Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family|Ymr1p; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    bait/hit Parrish WR (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     JNM1
  • INS1
  • PAC3
  • YMR294W
    		•  The BioGRID Database Seperator Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B|Jnm1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Schoner D (2008)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     TOR1
  • DRR1
  • YJR066W
    		•  The BioGRID Database Seperator PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis|Tor1p; protein coding
    Gene Ontology: [View List]
    Synthetic Growth Defect
    bait Zurita-Martinez SA (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YPT6
  • YLR262C
    		•  The BioGRID Database Seperator GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6|Ypt6p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARL3
  • YPL051W
    		•  The BioGRID Database Seperator Arl3p|GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RIC1
  • YLR039C
    		•  The BioGRID Database Seperator Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes|Ric1p; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     ARL1
  • DLP2
  • YBR164C
    		•  The BioGRID Database Seperator Arl1p|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor; protein coding
    Gene Ontology: [View List]
    Synthetic Lethality
    bait Tong AH (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     PMC1
  • YGL006W
    		•  The BioGRID Database Seperator Pmc1p|Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a; protein coding
    Gene Ontology: [View List]
    Dosage Rescue
    hit Hoffman-Sommer M (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
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