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BioGRID | Network Layout for CDC48 for Saccharomyces cerevisiae
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CDC48

 Saccharomyces cerevisiae
The BioGRID Database Seperator
Aliases: YDL126C
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Description: ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome|Cdc48p; protein coding
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Links: [Entrez-Gene]  [GeneDB]  [Germ Online]  [SGD]  
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Gene Ontology: 13 total GO annotations for this record. [view list]
The BioGRID Database Seperator
PIXEL
The BioGRID Database Seperator
Download interactions associated with CDC48

CDC48 was identified with 138 protein interactions and 10 genetic interactions
Displaying:
 Name Aliases The BioGRID Database Seperator Description
Evidence Code(s)
Role Source(s)
The BioGRID Database Seperator
 NPL4
  • HRD4
  • YBR170C
    		•  The BioGRID Database Seperator Endoplasmic reticulum and nuclear membrane protein, forms a complex with Cdc48p and Ufd1p that recognizes ubiquitinated proteins in the endoplasmic reticulum and delivers them to the proteasome for degradation|Npl4p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    hit Archambault V (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Two-hybrid
    bait Ito T (2001)
    Affinity Capture-Western
    bait Rape M (2001)
    bait Hitchcock AL (2001)
    bait Gauss R (2006)
    bait/hit Schuberth C (2005)
    Reconstituted Complex
    bait/hit Rumpf S (2006)
    Synthetic Lethality
    bait Rape M (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SHP1
  • UBX1
  • YBL058W
    		•  The BioGRID Database Seperator Shp1p|UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    bait Collins SR (2007)
    Two-hybrid
    hit Braun S (2002)
    hit Schuberth C (2004)
    Affinity Capture-Western
    bait Braun S (2002)
    hit Schuberth C (2004)
    bait Wilson JD (2006)
    Reconstituted Complex
    bait/hit Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD1
  • YGR048W
    		•  The BioGRID Database Seperator Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol|Ufd1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Gavin AC (2002)
    hit Archambault V (2004)
    hit Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    Affinity Capture-Western
    bait Rape M (2001)
    bait Richly H (2005)
    bait/hit Schuberth C (2005)
    Reconstituted Complex
    bait/hit Rumpf S (2006)
    Synthetic Lethality
    bait Rape M (2001)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DOA1
  • UFD3
  • ZZZ4
  • YKL213C
    		•  The BioGRID Database Seperator Doa1p|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Gavin AC (2002)
    bait Krogan NJ (2006)
    Affinity Capture-Western
    hit Ghislain M (1996)
    bait Rumpf S (2006)
    Two-hybrid
    hit Ghislain M (1996)
    bait/hit Decottignies A (2004)
    Reconstituted Complex
    bait Mullally JE (2006)
    bait/hit Rumpf S (2006)
    Co-purification
    bait Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFD2
  • YDL190C
    		•  The BioGRID Database Seperator Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3|Ufd2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Richly H (2005)
    bait Rumpf S (2006)
    Two-hybrid
    bait Richly H (2005)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    Co-purification
    bait Rumpf S (2006)
    Reconstituted Complex
    hit Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SEL1
  • UBX2
  • YML013W
    		•  The BioGRID Database Seperator Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain|Ubx2p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Archambault V (2004)
    bait Wilson JD (2006)
    Two-hybrid
    hit Schuberth C (2004)
    Affinity Capture-Western
    hit Schuberth C (2004)
    bait/hit Schuberth C (2005)
    bait Wilson JD (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX4
  • CUI1
  • YMR067C
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p|Ubx4p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Decottignies A (2004)
    hit Schuberth C (2004)
    Affinity Capture-Western
    hit Decottignies A (2004)
    hit Schuberth C (2004)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX7
  • CUI3
  • YBR273C
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p|Ubx7p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Decottignies A (2004)
    hit Schuberth C (2004)
    Affinity Capture-Western
    hit Decottignies A (2004)
    hit Schuberth C (2004)
    Affinity Capture-MS
    hit Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     YDR049W
  • YDR049W
    		•  The BioGRID Database Seperator Ydr049wp|Zinc finger protein; putative transcription factor that may interact with proteins involved in histone acetylation or deacetylation; may be involved in altering acetylation on histone lysines; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    bait Krogan NJ (2006)
    bait/hit Gavin AC (2006)
    hit Collins SR (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HRD1
  • DER3
  • YOL013C
    		•  The BioGRID Database Seperator Hrd1p|Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    bait Carvalho P (2006)
    Affinity Capture-Western
    bait Gauss R (2006)
    bait Schuberth C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX5
  • YDR330W
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p|Ubx5p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Schuberth C (2004)
    Affinity Capture-Western
    hit Schuberth C (2004)
    Affinity Capture-MS
    bait Krogan NJ (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX6
  • CUI2
  • YJL048C
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline|Ubx6p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    bait/hit Decottignies A (2004)
    hit Schuberth C (2004)
    Affinity Capture-Western
    hit Schuberth C (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     OTU1
  • YFL044C
    		•  The BioGRID Database Seperator Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family|Otu1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Krogan NJ (2006)
    Reconstituted Complex
    bait Rumpf S (2006)
    Affinity Capture-Western
    bait Rumpf S (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     CLN2
  • YPL256C
    		•  The BioGRID Database Seperator Cln2p|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait Archambault V (2004)
    Affinity Capture-Western
    hit Archambault V (2004)
    Phenotypic Suppression
    hit Fu X (2003)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     MRPS28
  • YDR337W
    		•  The BioGRID Database Seperator Mitochondrial ribosomal protein of the small subunit|Mrps28p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SMT3
  • YDR510W
    		•  The BioGRID Database Seperator Smt3p|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    bait/hit Panse VG (2004)
    bait Hannich JT (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     BNI1
  • PPF3
  • SHE5
  • YNL271C
    		•  The BioGRID Database Seperator Bni1p|Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DER1
  • YBR201W
    		•  The BioGRID Database Seperator Der1p|Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Gauss R (2006)
    bait/hit Schuberth C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     RAI1
  • YGL246C
    		•  The BioGRID Database Seperator Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing|Rai1p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBX3
  • YDL091C
    		•  The BioGRID Database Seperator UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern|Ubx3p; protein coding
    Gene Ontology: [View List]
    Two-hybrid
    hit Schuberth C (2004)
    Affinity Capture-Western
    hit Schuberth C (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     SPT23
  • YKL020C
    		•  The BioGRID Database Seperator ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting|Spt23p; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Rape M (2001)
    hit Shcherbik N (2007)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     REG1
  • HEX2
  • PZF240
  • SPP43
  • YDR028C
    		•  The BioGRID Database Seperator Reg1p|Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-MS
    hit Gavin AC (2002)
    hit Gavin AC (2006)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     HMG2
  • YLR450W
    		•  The BioGRID Database Seperator Hmg2p|One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    hit Rabinovich E (2002)
    bait Schuberth C (2005)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UBI4
  • SCD2
  • UB14
  • YLL039C
    		•  The BioGRID Database Seperator Ubi4p|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein coding
    Gene Ontology: [View List]
    Reconstituted Complex
    bait Rape M (2001)
    Two-hybrid
    bait/hit Decottignies A (2004)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     UFE1
  • YOR075W
    		•  The BioGRID Database Seperator Ufe1p|t-SNARE required for ER membrane fusion and vesicular traffic, integral membrane protein that constitutes with Sec20p and Use1p the trimeric acceptor for R/v-SNAREs on Golgi-derived vesicles at the ER; part of Dsl1p complex; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait Patel SK (1998)
    Dosage Rescue
    bait/hit Patel SK (1998)
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     DFM1
  • YDR411C
    		•  The BioGRID Database Seperator Dfm1p|ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes; protein coding
    Gene Ontology: [View List]
    Affinity Capture-Western
    bait/hit Sato BK ()
    Dosage Growth Defect
    hit Sato BK ()
    The BioGRID Database Seperator
    The BioGRID Database Seperator
    The BioGRID Database Seperator
     FAR1
  • YJL157C
    		•  The BioGRID Database Seperator Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate|Far1p; protein coding